Annals of Occupational and Environmental Medicine

Yun Jung Yang

3 Articles

Acute Toxicity of Administered Bisphenol A Di Glycidyl Ether in Male Sprague Dawley Rats: Jae un Im, Yun jung Yang, Tae jin Lee, Yeon pyo Hong; Korean Journal of Occupational and Environmental Medicine 2006;18(4):318-326. Published online December 31, 2006; DOI: https://doi.org/10.35371/kjoem.2006.18.4.318

OBJECTIVES
Bisphenol A Di Glycidyl Ether (BADGE) is the major component in commercial liquid epoxy resins, which are manufactured by co-reacting bisphenol A with epichlorohydrin. The authors investigated the acute toxicity of BADGE.
METHODS
BADGE was administered by a gavage to 8 week old SPF Sprague Dawley rats in a single dose of 0 (negative control), 0.37 (Diethylstilbesterol, DES), 1000, 2000, 4000, and 8000 mg/kg/day of BADGE. Each treatment group contained 7 rats. The general status and weight of the rats were observed for 14 days. The rats were anesthetized by ether at 14 days, and the changes in morphology, organ weight, sperm count and motility, and hormone level were measured.
RESULTS
All the rats treated with BADGE had diarrhea on the 1st day. The rats administered BADGE at 1000, 2000, and 4000 mg/kg/day showed a soiled perineal region and soft stools with diarrhea until the 3rd day. The 8000 mg/kg/day BADGE rats had diarrhea for two days followed by emaciation, soiled fur, a soiled perineal region, staining around the mouth and were moribund for three to eight days. No weight gain was observed after the 1st day in the 2000, 4000, and 8000 mg/kg/day BADGE rats and after the 7th day in all the treatment groups compared with the control groups. Some treatment groups were observed to have a decrease in the weight of the heart (BADGE 1000, 2000 and 4000 mg/kg/day), liver (BADGE 1000, 2000, 4000 and 8000 mg/kg/day) and prostate (BADGE 4000 mg/kg/day) compared with control group. The weight of the liver was significantly lower in all treatment groups compared with the control group. The relative weight of the liver (BADGE 1000 and 4000 mg/kg/day) was significant lower than the control. No pathological changes were observed in the brain, liver, thyroid, heart, spleen, kidney, lung and prostate. The number of spermatid in the seminiferous tubule in the testes was lower in all treatment groups than the control. The sperm motility tended to decrease with increasing concentration but the sperm count was similar in all treatment groups. The plasma Estrogen and testosterone level were similar in the control and treatment groups.
CONCLUSIONS
These results suggest that BADGE induces general, hepatic and reproductive toxicity at 1000 mg/kg/day.

Citations

Citations to this article as recorded by

Distribution of serum bisphenol A diglycidyl ether and its metabolite in Korean adult men and its association with reproductive hormone levels
Sang-il Kim, Yun-jung Yang, Yeon-pyo Hong, Soon-Chul Myung, Sae-Chul Kim
Molecular & Cellular Toxicology.2015; 11(1): 71. CrossRef
Acute Testis Toxicity of Bisphenol A Diglycidyl Ether in Sprague-Dawley Rats
Yun-jung Yang, Shin-young Lee, Kyung-yong Kim, Yeon-pyo Hong
Journal of Preventive Medicine and Public Health.2010; 43(2): 131. CrossRef

24 View
0 Download
2 Crossref

Validation of High Performance Liquid Chromatographic Method with UV Detector for the Determination of Di(2-ethylhexyl)Phthalate in Plasma in some Korean Male Workers: Yun Jung Yang, Soon Chul Myoung, Sae Chul Kim, Yeon Pyo Hong; Korean Journal of Occupational and Environmental Medicine 2005;17(1):70-78. Published online March 31, 2005; DOI: https://doi.org/10.35371/kjoem.2005.17.1.70

Abstract PDF

OBJECTIVES
This study was conducted to validate a simple, rapid and sensitive reverse-phase high-performance liquid chromatographic method with UV detector (HPLC-UV) and present the plasma level of di(2-ethylhexyl)phthalate (DEHP) in some Korean male workers.
METHODS
HPLC-UV for quantification of plasma DEHP was validated by the following guideline from the Center for Drug Evaluation and Research (CDER)-calibration/standard curve, precision, accuracy and recovery. Plasma DEHP from 255 healthy Korean male workers aged from 30 to 60 years was analyzed by validated HPLC-UV method.
RESULTS
The calibration curve over the range 0~150 microgram/liter for the plasma DEHP standard solution showed linearity(r2=0.999). The limit of detection (LOD) and limit of quantification (LOQ) of plasma DEHP were 5.22 microgram/liter and 15.81 microgram/liter, respectively. The accuracy and precision for 2.5 microgram/liter of DEHP were acceptable in CDER guideline on the second and third day but not first day, and those for 50 microgram/liter and 150 microgram/liter of DEHP were acceptable on all three days(Ed-confirm this addition). The distribution of plasma DEHP level was skewed to the left and ranged from 0 to 18.9 microgram/liter. The plasma DEHP level was lower than 10 microgram/liter for 98 % of subjects and lower than 5 microgram/liter for 85 %. The geometric mean and standard deviation of plasma DEHP were 0.4 +/- 1.5 microgram/liter.
CONCLUSIONS
The HPLC-UV method for quantification of plasma DEHP was acceptable by CDER guideline. The plasma DEHP of 255 Korean male workers ranged from 0 to 18.9 microgram/liter and the distribution was skewed to the left.

Citations

Citations to this article as recorded by

Assessment of Di (2-ethylhexyl) Phthalate Exposure by Urinary Metabolites as a Function of Sampling Time
Moon-seo Park, Yun-jung Yang, Yeon-pyo Hong, Sang-yon Kim, Yong-pil Lee
Journal of Preventive Medicine and Public Health.2010; 43(4): 301. CrossRef

22 View
0 Download
1 Crossref

A Study on the Factors affecting Pesticide Poisoning of a Rural Population: Sung Kyun Park, Sang Min Nam, Gyu Seok Hwang, Hyunme Park, Soo Eun Chung, Eun Ju Kim, Hee Sun Kim, Byung Kwan Sun, Yun Jung Yang, Eun Hee Lee, Hyung Doo Cho; Korean Journal of Occupational and Environmental Medicine 1999;11(2):196-205. Published online June 30, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.2.196

Abstract PDF

The purpose of this study is to examine the pesticide use and the relationship between keeping the safety rules or use of protective equipments, and poisoning experience. For Puksan province, Choonchun county, we obtained questionnaire data concerning pesticide poisoning and relating factors from 143 people who have farmed and have sprayed pesticides. Important results are follows: 1. The rate of experiences of pesticide poisoning was 33%, and the major symptoms were dizziness(39. 13%), vomiting(20.87%), and visual opacity(11.30%). The most frequent use of pesticide was paraquat(23. 76%), and the next was organophosphates(18.35%). 2. Logistic regression and chi-square analyses showed that duration of spraying per day, following dose limits, and spraying back against wind are significantly associated with poisoning experiences(x2=5.620, p0.018, OR=0.326, CJ=0.109-0.968, OR=0.302, OR=0.097-0.939 respectively). But no associations between poisoning experiences and age, sex, use of protective equipments, and attendance of safety education. Based on these data, despite limitations in exposure assessment and recall biases, it may be necessary to devise a counterplan for development of effective safety education that prevents pesticide poisoning such as popular education in CATA pesticide project, as well as prohibition of use of hazardous pesticides that proved to be fatal.

Citations

Citations to this article as recorded by

The Occupational Diseases of Agricultural Workers
Soo-Jin Lee
Hanyang Medical Reviews.2010; 30(4): 305. CrossRef
Overview of Pesticide Poisoning in South Korea
Won Jin Lee, Eun Shil Cha
Journal of Rural Medicine.2009; 4(2): 53. CrossRef
Work-related Injuries and Diseases of Farmers in Korea
Kwan LEE, Hyun-Sul LIM
INDUSTRIAL HEALTH.2008; 46(5): 424. CrossRef

26 View
0 Download
3 Crossref

Author index