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Validation of New Derivatization Procedure for the Determination of Hippuric Acid in Urine Using Gas Chromatography
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Soo Hun Cho, Yong Hyeon Yim, Sun Min Kim, Ho Jang Kwon, Mi na Ha, Sang Hwan Han
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Korean Journal of Occupational and Environmental Medicine 1995;7(1):58-62. Published online February 28, 1995
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DOI: https://doi.org/10.35371/kjoem.1995.7.1.58
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 Abstract
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- Urinary hippuric acid was analyzed by gas chromatography/mass spectrometry method. A simple and economical derivatization procedure using excessive methanol in acidic condition was adopted to esterify hippuric acid. Quantitative analysis was performed with two internal standards, heptadecanoic acid and hydrocinnamic acid, to evaluate the derivatization procedure as an analytical method. Using the standard addition method, linear and reproducible calibration curves were obtained for both internal standards. Calibration experiment showed that good quantitative result could also be obtained with the calibration curve obtained without urine matrix. Recovery rates for the urine samples were in the range of 95.6~111.4%. Using hydrocinnamic acid as internal standard, analysis time could be reduced.
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Citations
Citations to this article as recorded by  - Relationships between airborne exposure and urinary metabolites of nail technicians
Jin Hee Yang, Ji Young Kim, Aeyong Eom, Hee Kyoung Hyoung, Sang Baek Koh
Toxicology and Environmental Health Sciences.2010; 2(3): 175. CrossRef
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Assessment of Environmental Monitoring Items for Mixed Organic Solvents in Work Place
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Soo Hun Cho, Ho Jang Kwon, Mi Na Ha, Sang Hwan Han, Yong Hyeon Yim, Sung Tae Oh
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Korean Journal of Occupational and Environmental Medicine 1994;6(2):259-269. Published online September 30, 1994
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DOI: https://doi.org/10.35371/kjoem.1994.6.2.259
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- Ambient air monitoring(environmental monitoring) and biological monitoring of mixed organic solvents exposure have been used in exposure assessment of these compounds in the work environment. Environmental monitoring is more useful when assessing low level exposure to these compounds. The specific objectives of this study were to measure air organic solvent levels in the work environment, to test the agreement of items measured in this study with items which have been reported to the administrative agency, and finally to evaluate the appropriateness of environmental monitoring items. The study subjects were 13 small companies in which less than 300 employees were working and presumably exposed to mixed organic solvents(e.g. automotive repair and painting, 6; textile dyeing, 2; printing, 2; electronics, etc, 3). Personal air samplings were performed by the flow-lite sampling pump(MSA) and the 600mg charcoal tube with air velocity of 100ml/min for qualitative analysis and 2l/min for quantitative analysis. Samples were analysed by gas chromatography/mass spectrometry(Hewlett-Packard 5890/5970).
High levels of toluene, n-hexane, and MIBK were detected in most study companies and low levels of ethylbenzene, xylene, n-butylacetate were also detected. When these measured items were compared with those of reported items, only 6 of 13 companies showed relatively good agreement between them. Two companies failed to report items exceeding the limit value. In conclusion, qualitative analysis of ambient air organic solvents seemed to be as important as quantitative analysis of these compounds and a periodic evaluation of monitoring items reported to the administrative agency should be required.
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