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Association between cadmium and anti-Mullerian hormone in premenopausal women at particular ages
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Yu min Lee, Hye Won Chung, Kyungah Jeong, Yeon-Ah Sung, Hyejin Lee, Shinhee Ye, Eun-Hee Ha
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Ann Occup Environ Med 2018;30:44. Published online July 9, 2018
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DOI: https://doi.org/10.1186/s40557-018-0255-7
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 Abstract
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- Background
Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age. MethodsIn a cross-sectional study, the data of premenopausal women living in Seoul, ranging from 30 to 45 of age was collected. The study included a total of 283 women who completed serum AMH and whole blood cadmium assessments. Linear regression analyses were used in order to examine the association between cadmium and AMH. Given that age was the strongest confounder in both cadmium and AMH concentrations, we stratified subjects by 5 years old and analyzed their data. ResultsGeometric mean concentrations of blood cadmium and AMH were 0.97 μg/L and 3.02 ng/ml, respectively. Total association between cadmium and AMH was statistically significant (adjusted coefficient = − 0.34 (0.15), p = 0.02). After stratification, the only age group with a negative association between cadmium and AMH were the women raging between 30 and 35 years (adjusted coefficient = − 0.43 (0.18), p = 0.01). ConclusionsThe results of this study suggest that environmental exposure to cadmium may alter the AMH level of premenopausal women, depending on their age group.
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Citations
Citations to this article as recorded by  - Exposure to heavy metallic and trace essential elements and risk of diminished ovarian reserve in reproductive age women: A case-control study
Tian Tian, Zheng Wang, Fang Liu, Yu Fu, Fei Kong, Yuanyuan Wang, Qin Li, Xiaoyu Long, Jie Qiao
Journal of Hazardous Materials.2024; 470: 134206. CrossRef - Associations between follicular fluid trace elements and ovarian response during in vitro fertilization
Rooshna Mohsin, Victor Y. Fujimoto, Aubrey L. Galusha, Patrick J. Parsons, Jenna R. Krall, Celeste D. Butts-Jackson, Evelyn Mok-Lin, Michael S. Bloom
Environmental Research.2024; 252: 118801. CrossRef - Heavy Metals and Trajectories of Anti-Müllerian Hormone During the Menopausal Transition
Ning Ding, Xin Wang, Siobán D Harlow, John F Randolph, Ellen B Gold, Sung Kyun Park
The Journal of Clinical Endocrinology & Metabolism.2024;[Epub] CrossRef - Heavy metals and diminished ovarian reserve: single-exposure and mixture analyses amongst women consulting in French fertility centres
Maximilien Génard-Walton, Charline Warembourg, Solène Duros, Martine Ropert-Bouchet, Tiphaine Lefebvre, Anne Guivarc'h-Levêque, Marie-Thérèse Le Martelot, Bénédicte Jacquemin, Sylvaine Cordier, Nathalie Costet, Luc Multigner, Ronan Garlantézec
Reproductive BioMedicine Online.2023; 47(3): 103241. CrossRef - Urinary cadmium and endometriosis prevalence in a US nationally representative sample: results from NHANES 1999–2006
Mandy S Hall, Nicole M Talge, Kristen Upson
Human Reproduction.2023; 38(9): 1835. CrossRef - Does the environment affect menopause? A review of the effects of endocrine disrupting chemicals on menopause
L. Levine, J. E. Hall
Climacteric.2023; 26(3): 206. CrossRef - Associations between exposure to cadmium, lead, mercury and mixtures and women’s infertility and long-term amenorrhea
Maria McClam, Jihong Liu, Yihan Fan, Tingjie Zhan, Qiang Zhang, Dwayne E. Porter, Geoffrey I. Scott, Shuo Xiao
Archives of Public Health.2023;[Epub] CrossRef - Multiple Targets of Toxicity in Environmental Exposure to Low-Dose Cadmium
Soisungwan Satarug, Glenda C. Gobe, David A. Vesey
Toxics.2022; 10(8): 472. CrossRef - Maternal exposure to cadmium from puberty through lactation induces abnormal reproductive development in female offspring
Chengxi Li, Bo Wang, Xue Lu, Yichao Huang, Hua Wang, Dexiang Xu, Jun Zhang
Ecotoxicology and Environmental Safety.2022; 242: 113927. CrossRef - The environment and female reproduction: Potential mechanism of cadmium poisoning to the growth and development of ovarian follicle
Jingwen Qu, Qiang Wang, Xiaomei Sun, Yongjun Li
Ecotoxicology and Environmental Safety.2022; 244: 114029. CrossRef - Invited Commentary: Theoretical Considerations and Real-World Challenges for Research on Proxy Exposures and Ovarian Reserve
Brian W Whitcomb
American Journal of Epidemiology.2021; 190(1): 125. CrossRef - Associations between blood cadmium and endocrine features related to PCOS-phenotypes in healthy women of reproductive age: a prospective cohort study
Keewan Kim, Anna Z. Pollack, Carrie J. Nobles, Lindsey A. Sjaarda, Jessica R. Zolton, Jeannie G. Radoc, Enrique F. Schisterman, Sunni L. Mumford
Environmental Health.2021;[Epub] CrossRef - Cadmium Exposure and Ovarian Reserve in Women Aged 35–49 Years: The Impact on Results From the Creatinine Adjustment Approach Used to Correct for Urinary Dilution
Kristen Upson, Katie M O’Brien, Janet E Hall, Erik J Tokar, Donna D Baird
American Journal of Epidemiology.2021; 190(1): 116. CrossRef - Urinary cadmium concentrations and risk of primary ovarian insufficiency in women: a case–control study
Wuye Pan, Xiaoqing Ye, Zheying Zhu, Chunming Li, Jianhong Zhou, Jing Liu
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Martin Massányi, Soisungwan Satarug, Roberto Madeddu, Robert Stawarz, Peter Massányi
Stresses.2021; 2(1): 1. CrossRef - Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs
Peter Massányi, Martin Massányi, Roberto Madeddu, Robert Stawarz, Norbert Lukáč
Toxics.2020; 8(4): 94. CrossRef - Toenail metal concentrations and age at menopause
Alexandra J. White, Katie M. O’Brien, Nicole M. Niehoff, Brian P. Jackson, Margaret R. Karagas, Clarice R. Weinberg, Alexander P. Keil
Environmental Epidemiology.2020; 4(4): e0104. CrossRef
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Blood cadmium and volume of uterine fibroids in premenopausal women
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Shinhee Ye, Hye Won Chung, Kyungah Jeong, Yeon-Ah Sung, Hyejin Lee, So Yun Park, Hyunjoo Kim, Eun-Hee Ha
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Ann Occup Environ Med 2017;29:22. Published online June 22, 2017
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DOI: https://doi.org/10.1186/s40557-017-0178-8
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Abstract
PDFPubReaderePub
- Background
A number of studies have found associations between heavy metals and uterine fibroids, but the results are inconsistent. Here, we conducted this research to demonstrate the relationships between blood heavy metal concentrations and uterine fibroid volume as well as the rate of uterine fibroid presence. MethodsIn a cross-sectional study, we collected data from 308 premenopausal women aged 30–49 years in Seoul; uterine fibroids are ascertained by past history of myomectomy and pelvic ultrasonography. In the analytic phase, we first analyzed the presence of the fibroids and the concentrations of heavy metals via logistic regression. In subgroup analysis, we used simple and multiple linear regression analyses to examine the associations between heavy metals and uterine fibroid volume. ResultsThere was no connection between the heavy metal concentrations and the presence of uterine fibroids, but the odds of women having fibroids were higher with three particular metals. In subgroup analysis, the association between blood cadmium concentrations and uterine fibroid volume was statistically significant (adjusted beta coefficient = 2.22, 95% confidential interval: 0.06–4.37). In contrast, blood mercury and lead concentrations were not significantly associated with uterine fibroid volume. ConclusionsOur findings are the first that we know to report the association of blood cadmium concentrations with the volume of uterine fibroids. We expect that our findings will be used as evidence for supporting policies to improve premenopausal Korean women’s health.
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Citations
Citations to this article as recorded by - The adverse role of endocrine disrupting chemicals in the reproductive system
Jing Pan, Pengfei Liu, Xiao Yu, Zhongming Zhang, Jinxing Liu
Frontiers in Endocrinology.2024;[Epub] CrossRef - Association between the concentrations of some toxic metals and the risk of uterine fibroids among Nigerian women
Fatimoh Bukola Kareem, Mathias Abiodun Emokpae
Environmental Disease.2022; 7(4): 96. CrossRef - Prolonged Cadmium Exposure Alters Migration Dynamics and Increases Heterogeneity of Human Uterine Fibroid Cells—Insights from Time Lapse Analysis
Yitang Yan, Min Shi, Rick Fannin, Linda Yu, Jingli Liu, Lysandra Castro, Darlene Dixon
Biomedicines.2022; 10(4): 917. CrossRef - Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health
Jelonia T. Rumph, Victoria R. Stephens, Joanie L. Martin, LaKendria K. Brown, Portia L. Thomas, Ayorinde Cooley, Kevin G. Osteen, Kaylon L. Bruner-Tran
International Journal of Environmental Research and Public Health.2022; 19(3): 1257. CrossRef - An Assessment of Metallothionein–Cadmium Binding in Rat Uterus after Subchronic Exposure Using a Long–Term Observation Model
Marzenna Nasiadek, Joanna Stragierowicz, Anna Kilanowicz
International Journal of Molecular Sciences.2022; 23(23): 15154. CrossRef - Uterine Fibroids and Diet
Andrea Tinelli, Marina Vinciguerra, Antonio Malvasi, Mladen Andjić, Ivana Babović, Radmila Sparić
International Journal of Environmental Research and Public Health.2021; 18(3): 1066. CrossRef - Combined Exposure to Multiple Endocrine Disruptors and Uterine Leiomyomata and Endometriosis in US Women
Yuqing Zhang, Yingying Lu, Huiyuan Ma, Qing Xu, Xiaoli Wu
Frontiers in Endocrinology.2021;[Epub] CrossRef - Prolonged cadmium exposure alters benign uterine fibroid cell behavior, extracellular matrix components, and TGFB signaling
Yitang Yan, Jingli Liu, Arianna Lawrence, Michael J. Dykstra, Rick Fannin, Kevin Gerrish, Charles J. Tucker, Erica Scappini, Darlene Dixon
The FASEB Journal.2021;[Epub] CrossRef - “Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells
Linda Yu, Jingli Liu, Yitang Yan, Alanna Burwell, Lysandra Castro, Min Shi, Darlene Dixon
Archives of Toxicology.2021; 95(6): 1995. CrossRef - Environmental Factors Involved in Maternal Morbidity and Mortality
Abee L. Boyles, Brandiese E. Beverly, Suzanne E. Fenton, Chandra L. Jackson, Anne Marie Z. Jukic, Vicki L. Sutherland, Donna D. Baird, Gwen W. Collman, Darlene Dixon, Kelly K. Ferguson, Janet E. Hall, Elizabeth M. Martin, Thaddeus T. Schug, Alexandra J. W
Journal of Women's Health.2021; 30(2): 245. CrossRef - A nongenomic mechanism for “metalloestrogenic” effects of cadmium in human uterine leiomyoma cells through G protein-coupled estrogen receptor
Jingli Liu, Linda Yu, Lysandra Castro, Yitang Yan, Maria I. Sifre, Carl D. Bortner, Darlene Dixon
Archives of Toxicology.2019; 93(10): 2773. CrossRef
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