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Toxic Hepatitis Induced by Occupational Dimethylacetamide Exposure
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Tae Sung Choi, Kuck Hyeun Woo, Jin Seok Kim, Wan Seup Park, Jung Ho Ham, Sang Je Jung, Jae Young Yu
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Korean Journal of Occupational and Environmental Medicine 2001;13(2):164-170. Published online June 30, 2001
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DOI: https://doi.org/10.35371/kjoem.2001.13.2.164
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 Abstract
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- Dimethylacetamide is widely used in the production of plastics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid of dimethylacetamide(DMAC) can cause liver damage. Toxic hepatitis possibly attributable to DMAC exposure occurred in seven works among 178 employees who had worked on a new spandex-fiber production line. A large amount of DMAC is used as a spinning solvent for synthetic fibers in the factory. The patients were aged 23-47 years old and composed of five males and two females. They were involved in the process of polymerization(1 patient), spinning(1), take-up(4) and packaging(1). The mean duration of exposure was 10 weeks. They experienced fatigue, dizziness and jaundice. The patients showed elavated total bilirubin, alanine aminotransferase(ALT), and aspartate aminotransferase(AST) levels. The serologic test for viral hepatitis A, B and C were negative, as were the abdominal ultrasonographic scans. Based on the presumptive diagnosis of DMAC-induced toxic hepatitis, they were removed from the workplaces. One or two months after removal from the work, the transaminase levels returned to normal. The patients had no history of significant alcohol use, blood transfusion, recent medication, and drug abuse. As a result, authors could not find any attributable cause of toxic hepatitis but the toxicity by DMAC exposure.
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Citations
Citations to this article as recorded by  - Intravenous Busulfan, Dimethylacetamide and neurotoxicity after high-dose pretransplant conditioning chemotherapy
J. Ramdial, K. H. Chan, G. Sanchez Petitto, B. Valdez, B. S. Andersson, Y. Nieto
Bone Marrow Transplantation.2023; 58(6): 635. CrossRef - A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef - A green approach to porous and dense antifouling membranes through solvent-free bulk polymerization
Runnan Zhang, Jinming Peng, Yanlei Su, Xiaochen Fan, Zhongyi Jiang, Xueting Zhao, Jiazhen Liu, Yafei Li, Jiaojiao Zhao
Chemical Engineering Science.2015; 135: 501. CrossRef - Grand Rounds: An Outbreak of Toxic Hepatitis among Industrial Waste Disposal Workers
Hae-Kwan Cheong, Eun A Kim, Jung-Keun Choi, Sung-Bong Choi, Jeong-Ill Suh, Dae Seob Choi, Jung Ran Kim
Environmental Health Perspectives.2007; 115(1): 107. CrossRef - Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers
C-Y Lee, S-J Jung, S-A Kim, K-S Park, B-G Ha
Occupational and Environmental Medicine.2006; 63(10): 688. CrossRef
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Two Cases of Convulsion Associated With Caprolactam
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Kuck Hyeun Woo, Sang Je Jung, Wan Seup Park, Hea Ryeon Shin, Jin Seok Kim, Sang Woo Kim
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Korean Journal of Occupational and Environmental Medicine 1998;10(1):116-120. Published online February 28, 1998
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DOI: https://doi.org/10.35371/kjoem.1998.10.1.116
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Abstract
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- Two young men were seen with nausea, vomiting, dermatitis, seizure after two-four days of occupational exposure to caprolactam, a nylon fiber precursor. There were no significant results in laboratory test, brain CT, EEG except leukocytosis, hyperglycemia. Caprolactam has been shown to induce convulsive disorder in experimental animal studios and Tuma et al (1981) described that one worker acutely exposed to caprolactam developed generalized tonic-clonic seizure with leukocytosis. The coincidence of typical skin lesion with otherwise unexplained generalized tonic-clonic seizure in those young man strongly suggests that caprolactam was causal agent.
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