Annals of Occupational and Environmental Medicine

Tae Sung Choi

7 Articles

Incidence of Dimethylacetamide Induced Toxic Liver Injury among Workers in a Synthetic Fiber Manufacturing Company: Yong Seok Jang, Seong Yong Yoon, Seong Yong Jo, Tae Sung Choi, Jay Young Yoo, Kuck Hyun Woo, Bong Goo Ha, Sang Jae Jung, Byung Yeol Chun, Jin Seok Kim; Korean Journal of Occupational and Environmental Medicine 2006;18(3):246-254. Published online September 30, 2006; DOI: https://doi.org/10.35371/kjoem.2006.18.3.246

OBJECTIVES
The main goal of this study was to find the incidence of the dimethylacetamide (DMAc) induced toxic liver injury among workers who were exposed to DMAc for about 5 years in a synthetic fiber factory.
METHODS
In our investigation, total 1,021 workers had been exposed to DMAc from 1st February, 2000 to 30th June, 2004. Among them, 24 workers who had initial abnormal hepatic enzyme level or was viral hepatitis B carrier were excluded. Finally, 997 DMAc exposed workers were followed up for their incidence of toxic liver injury. To find out DMAc induced toxic liver injury case, we carried out regular examinations including liver enzyme tests such as AST and ALT.
RESULTS
We followed up 997 workers and among them 72 cases coincided with our case definition. Incidence density method was 6.05 per 100 person-year. and, a cumulative incidence by life table method was 0.0965 within a year. The incidence of the DMAc-induced toxic liver injury peaked at 4 to 5 in weeks after employment. There was no toxic liver injury case within second week after exposure to DMAc. Five new cases developed in 2th to 3th week, 25 cases in 4th to 5th week, 14 cases in 6th to 7th week, 12 cases in 8th to 9th week, 5 cases in 10th to 11th week, 4 cases in 12th to 13th week, 4 cases in 14th to 15th week, 1 case in 16th to 17th week, 1 case in 30th to 31th week, and there was one case in 48th to 49th week.
CONCLUSIONS
The incidence rate of toxic liver injury was considerably high during the 1st year after a worker is placed. So it is needed to take careful monitoring of hepatic enzyme level for newly exposed worker.

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A review of life table applications and an introduction of its application method
Kyoungjin Shin, Boseung Choi
Journal of the Korean Data and Information Science Society.2013; 24(6): 1159. CrossRef
Occupational Hepatic Disorders in Korea
Hyoung Ryoul Kim, Tae Woo Kim
Journal of Korean Medical Science.2010; 25(Suppl): S36. CrossRef
Current status of liver diseases in Korea: Toxic and alcoholic liver diseases
Kyung-Ah Kim
The Korean Journal of Hepatology.2009; 15(Suppl 6): S29. CrossRef

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Surveillance of Work-related Diseases in Kumi: Seong Ah Kim, Jin Seok Kim, Hae Ree Jeon, Sang Jae Jung, Sang Woo Kim, Chae Yong Lee, Jung O Ham, Jay Young Yoo, Tae Sung Choi, Ha Bong Goo, Min Hwan Cho, Kuck Hyun Woo; Korean Journal of Occupational and Environmental Medicine 2003;15(1):95-110. Published online March 31, 2003; DOI: https://doi.org/10.35371/kjoem.2003.15.1.95

Abstract PDF

OBJECTIVES
Area-based occupational disease surveillance in Kumi (KODS) was used to collect data on occupational diseases. The data was used to estimate the magnitude of the diseases, to analyze for their characteristics, and to find links for their intervention and prevention.
METHODS
Since January 2001, occupational physicians and nurses in Occupational Health Service (OHS)have reported six major occupational diseases; occupational musculoskeletal disorders of the upper extremities(MSDUE), occupational dermatoses, toxic hepatitis, occupational asthma (OA), hand-arm vibration syndrome(HAVS), and occupational cancer. For the respective diseases, a reporting sheet and operational diagnostic criteria were developed by the KODS. An analysis of the KODS data, collected over a certain period, was compared with data from the Korea Labor Workers Corporation (KLWC) and the Specific Health Examination (SHE), and the incidence rates of the diseases estimated.
RESULTS
Between Jan 2001 and Apr 2002, 287 cases of the six major occupational disease were reported. Of these, there were 132 (46.0%), 100 (34.8%), 34 (11.8%), 16 (5.6%), and 5 (1.7%), cases of MSDUE, occupational dermatoses, toxic hepatitis, OA, and HAVS, respectively. But, there were no cases of occupational cancer. 33 (11.5%) of the incidence were reported via the OHS, 206 (71.7%) from health checkups, and the other 48(16.8%) from other routes. The synthetic fibers and electronic components manufacturing industries accounted for the greatest number of reported cases. With respect to occupation, the greatest numbers of incidence were reported from the elementary occupations, textile workers, assemblers, and cooks and food services worker, in that order. Of the MSDUE cases, carpal tunnel syndrome and epicondylitis were the two most common diseases. Most of the occupational dermatoses were due to contact dermatitis, with organic solvents (59%), nickel (6%), and epoxy resin (5%) accounting for the majority of these cases. All cases of toxic hepatitis were induced by dimethylformamide or dimethylacetamide, which were reported by a unique monitoring system. During same period, there were no cases claimed by workers to the KLWC, and only three cases from SHE, were identified. Using data from workers' number and surveillance, the annual incidences of MSDUE, dermatoses, hepatitis, OA, and HAVS, per 100,000 workers were 63.6, 48.2, 17.9, 7.7, and 2.4, respectively.
CONCLUSIONS
These results show that an area-based surveillance system can be very effective for the collection of data on work-related diseases, at least in Kumi.

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Distribution of age, gender, and occupation among individuals with carpal tunnel syndrome based on the National Health Insurance data and National Employment Insurance data
Il-Ho Lee, Young-Ki Kim, Dong-Mug Kang, Se-Yeong Kim, In-Ah Kim, Eun-Mi Kim
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef
Work-relatedness of lung cancer by smoking and histologic type in Korea
Young-Il Lee, Sang-Gil Lee, Dong-Mug Kang, Jong-Eun Kim, Young-Ki Kim, Jong-Han Leem, Hwan-Cheol Kim
Annals of Occupational and Environmental Medicine.2014;[Epub] CrossRef
Clinical Outcomes of Occupational Exposure to N,N-Dimethylformamide: Perspectives from Experimental Toxicology
Tae Hyun Kim, Sang Geon Kim
Safety and Health at Work.2011; 2(2): 97. CrossRef
Occupational Skin Diseases in Korea
Yeon-Soon Ahn, Min-Gi Kim
Journal of Korean Medical Science.2010; 25(Suppl): S46. CrossRef
Occupational Hepatic Disorders in Korea
Hyoung Ryoul Kim, Tae Woo Kim
Journal of Korean Medical Science.2010; 25(Suppl): S36. CrossRef
Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers
C-Y Lee, S-J Jung, S-A Kim, K-S Park, B-G Ha
Occupational and Environmental Medicine.2006; 63(10): 688. CrossRef

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The Needle Stick Injuries of Interns and Residents Working in Hospitals in a City: Shin Goo Park, Jong Young Lee, Jung Hup Song, Jay Young Woo, Tae Sung Choi; Korean Journal of Occupational and Environmental Medicine 2002;14(1):69-77. Published online March 31, 2002; DOI: https://doi.org/10.35371/kjoem.2002.14.1.69

Abstract PDF

OBJECTIVES
This study was conducted in order to assess the experience of needle stick injury among interns and residents working in hospitals during the previous 4 months.
METHODS
We conducted a questionnaire survey of 695 interns and residents working in two university hospitals and one general hospital in Tague city. Four hundred and forty three of those questioned(63.7 %) fully responded.
RESULTS
Two hundred of the respondents(45.1 %) suffered at least one injury. Respondents suffered an average of 1.8 injuries. 96.5 % of interns, 40.6 % of surgical residents and 34.4 % of non-surgical residents suffered at least one injury. According to multiple logistic regression, Intern status and an increased amount of working time is associated with high risk of needle stick injury.
CONCLUSIONS
This study demonstrates that interns and residents suffer a high rate of needle stick injury.

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A Study on the Status of Injuries Experience and Prevention in Dental Office
Mi-Hyun Choi, Hyun-Sook Bae
Journal of dental hygiene science.2015; 15(6): 845. CrossRef
Work-related Musculoskeletal Diseases and Occupational Injuries in Health Care Workers
Jung-Yeon Hong, Jung-Wan Koo
Journal of the Korean Medical Association.2010; 53(6): 446. CrossRef

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Ocular, Respiratory and Skin Symptoms Among Solderers Employed in Printed Circuit Board Assembly Units: Jay Young Yu, Kuck Hyeun Woo, Jin Seok Kim, Jung Oh Ham, Tae Sung Choi, Bong Goo Ha, Sang Je Jung, Shin Goo Park, Il Ryong Kim; Korean Journal of Occupational and Environmental Medicine 2001;13(4):423-435. Published online December 31, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.4.423

Abstract PDF

OBJECTIVES
This study was conducted to evaluate the prevalence of ocular, respiratory and skin symptoms among solderers and to investigate the relationship between symptom prevalence and exposure intensity.
METHODS
We analyzed 126 eligible participants out of a population of 146 male solderers who completed the symptom questionnaires. Fourteen symptoms including 'itchy and red eyes', 'itchy or prickly nose', 'sneezing', 'rhinorrhea', 'blocked nose', 'pricklythroat', 'foreign body sensation in throat', 'sudden bouts of coughing', 'exertional breathlessness ', 'wheezing', 'sputum production', 'itchy face or hands', 'acneiform eruptions on the face'and 'red spots on the face or hands'were contained. Blood lead levels of all the 126 participants were tested and the participants'own assessments of the health risk of soldering were collected.
RESULTS
Of the 14 investigated symptoms, 'sudden bouts of coughing'was significantly more prevalent in solderers who worked 4 hours or more a day than those who worked less than 4 hours a day, as for the other symptoms, there were no significant differences in the preva1ences related to daily soldering hours. 2.8% of the solderers considered the risk of flux exposure to be serious. The mean blood lead level was 6.05 microgram/dL (maximum 15.50 microgram /dL).
CONCLUSIONS
Soldering may increase the risk of respiratory symptoms. Further investigations on the hazards of soldering processes are warranted and solderers should be educated on these hazards.

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Skin Disease Among Staff in a Large Korean Nursing Home.
DEREK RICHARD SMITH, JAE-WOOK CHOI, DONG-SOO YU, MYUNG KI, CHUN-HWA OH, ZENTARO YAMAGATA
The Tohoku Journal of Experimental Medicine.2002; 198(3): 175. CrossRef

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Toxic Hepatitis Induced by Occupational Dimethylacetamide Exposure: Tae Sung Choi, Kuck Hyeun Woo, Jin Seok Kim, Wan Seup Park, Jung Ho Ham, Sang Je Jung, Jae Young Yu; Korean Journal of Occupational and Environmental Medicine 2001;13(2):164-170. Published online June 30, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.2.164

Abstract PDF

Dimethylacetamide is widely used in the production of plastics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid of dimethylacetamide(DMAC) can cause liver damage. Toxic hepatitis possibly attributable to DMAC exposure occurred in seven works among 178 employees who had worked on a new spandex-fiber production line. A large amount of DMAC is used as a spinning solvent for synthetic fibers in the factory. The patients were aged 23-47 years old and composed of five males and two females. They were involved in the process of polymerization(1 patient), spinning(1), take-up(4) and packaging(1). The mean duration of exposure was 10 weeks. They experienced fatigue, dizziness and jaundice. The patients showed elavated total bilirubin, alanine aminotransferase(ALT), and aspartate aminotransferase(AST) levels. The serologic test for viral hepatitis A, B and C were negative, as were the abdominal ultrasonographic scans. Based on the presumptive diagnosis of DMAC-induced toxic hepatitis, they were removed from the workplaces. One or two months after removal from the work, the transaminase levels returned to normal. The patients had no history of significant alcohol use, blood transfusion, recent medication, and drug abuse. As a result, authors could not find any attributable cause of toxic hepatitis but the toxicity by DMAC exposure.

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Intravenous Busulfan, Dimethylacetamide and neurotoxicity after high-dose pretransplant conditioning chemotherapy
J. Ramdial, K. H. Chan, G. Sanchez Petitto, B. Valdez, B. S. Andersson, Y. Nieto
Bone Marrow Transplantation.2023; 58(6): 635. CrossRef
A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef
A green approach to porous and dense antifouling membranes through solvent-free bulk polymerization
Runnan Zhang, Jinming Peng, Yanlei Su, Xiaochen Fan, Zhongyi Jiang, Xueting Zhao, Jiazhen Liu, Yafei Li, Jiaojiao Zhao
Chemical Engineering Science.2015; 135: 501. CrossRef
Grand Rounds: An Outbreak of Toxic Hepatitis among Industrial Waste Disposal Workers
Hae-Kwan Cheong, Eun A Kim, Jung-Keun Choi, Sung-Bong Choi, Jeong-Ill Suh, Dae Seob Choi, Jung Ran Kim
Environmental Health Perspectives.2007; 115(1): 107. CrossRef
Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers
C-Y Lee, S-J Jung, S-A Kim, K-S Park, B-G Ha
Occupational and Environmental Medicine.2006; 63(10): 688. CrossRef

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Related factors of high frequency hearing loss in the noise-exposed male workers: Sang Je Jung, Kuck Hyeun Woo, Wan Deup Park, Jae Young Yu, Tae Sung Choi, Sang Woo Kim, Jin Seok Kim; Korean Journal of Occupational and Environmental Medicine 2000;12(2):187-197. Published online June 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.2.187

Abstract PDF

OBJECTIVES
The purpose of the study was to assess the risk factors assumed to be related to the high frequency hearing loss in the noise-exposed male workers.
METHODS
712 occupationally noise-exposed male workers were included in this cross sectional study. The subjects filled out a questionnaire on the history of noise exposure, hearing protection, otologic diseases, tobacco smoking, and were tested on height, weight, hematocrit, serum total cholesterol level, fasting plasma glucose level and arterial blood pressure level. Pure tone audiometry and otoscopy were conducted and the subjects were allocated into two groups according to whether they had 4000 Hi hearing loss or not.
RESULTS
The multiple logistic regression analysis showed that military noise exposure, poor wearing status of the hearing protection devices, increased age, long noise exposure duration, mean arterial pressure less than 80mmHg, high fasting plasma sugar are the factors significantly related to high frequency hearing loss (P<0.05). On the contrary, there was no significant relationship between noise intensity, body mass index, serum total cholesterol level, smoking and high frequency hearing loss. Low hematocrit was shown to be a significant factor with a p-value less than 0.1.
CONCLUSIONS
High frequency hearing loss in the noise-exposed male workers is related to military noise exposure, use of hearing protection devices, age, noise exposure length, fasting glucose level and mean arterial pressure, in this order. Appropriate use of the hearing protection devices has a great impact on the prevention of the noise-induced hearing loss.

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The effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
Dae Yun Kim, A Ram Kim, Joo Hyun Sung, Choong Ryeol Lee, Jiho Lee
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef

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The Association of the Serum Magnesium with Hearing Loss Among Noise Exposed Male Workers: Wan Seoup Park, Jong Young Lee, Sang Jae Jung, Jae Young Yoo, Tae Sung Choi, Sung Chul Hong, Sung Chan No; Korean Journal of Occupational and Environmental Medicine 2000;12(1):12-25. Published online March 31, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.1.12

Abstract PDF: OBJECTIVES
This study was conducted to investigate that the chronic noise exposure is associated with decreased serum magnesium concentrations and evaluate whether decreased serum magnesium is associated with noise induced hearing loss.
METHODS
One hundred seventy-eight male workers exposed to noise were selected and classified three groups by the degree of hearing loss. Hearing threshold levels were less than 30 dB at 1,000 Hz or less than 40 dB at 4,000 Hz in group I, more than 30 dB at 1,000 Hz or more than 40 dB at 4,000 Hz and 15 dB and less of pure tone average(PTA: (500 Hz+1,000 Hz+2,000 Hz)/3) in group II, more than 30 dB at 1,000 Hz or more than 40 dB at 4, 000 Hz and over 15 dB of PTA in group III.
RESULTS
Serum magnesium concentrations were 2. 42+/-0. 26 nc/dt in group I, 2. 35+/-0.23 mg(dl in group II, 2.26+/-0.24 ne/dl in group III, respectively and significantly different between group I and group III (p<0. 01). It was negatively correlated with duration of the noise exposure as correlation coefficient(r) of -0.194 (p<0.05). Analysis of the multiple regression on hearing threshold levels showed that serum magnesium, diastolic blood pressure, duration of the noise exposure were statistically significant at 4,000 Hz(p<0.05). While only age was statistically significant at 1,000 Hz(p<0.05).
CONCLUSIONS
These results suggest that chronic noise exposure may induces decrease in serum magnesium concentrations and that its decreased concentration is related with noise induced hearing loss.

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