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The Association among Exposure of Bisphenol A, Genetic Polymorphism of Metabolic Enzyme and Urinary Metabolite
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Sang Baek Koh, Jun Ho Park, Su Song Yun, Sung Su Oh, Sei Jin Chang, Sun Haeng Choi, Bong Suk Cha
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Korean Journal of Occupational and Environmental Medicine 2008;20(2):112-118. Published online June 30, 2008
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DOI: https://doi.org/10.35371/kjoem.2008.20.2.112
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 Abstract
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- OBJECTIVES
To examine bisphenol A (BPA) exposure with subjects in the manufacturing industry and to determine its correlation with metabolites according to genetic polymorphism of metabolic enzymes.
METHODS
The study subjects comprised 104 workers in the manufacturing industry, 64 and 40 in the exposed and control groups, respectively. The questionnaire variablesincluded age, use of protective equipment, smoking habit and alcohol intake. Their urine samples were collected in the afternoon and urinary BPA concentration was measured by revising with the urinary creatinine concentration. The genetic polymorphism of the metabolic enzymes was examined by using restriction fragment length polymorphism (RFLP) after extracting DNA from leucocytes.
RESULTS
The minimum and maximum BPA level of the exposed group during working time was 34.22 and 221.20 ng/mg, respectively. The urinary BPA concentration was significantly higher in the exposed groups than in the control group. There was no significant difference in the urinary BPA level according to genetic polymorphism of CYP1A1 and CYP2E1, but UGT1A6 showed a significant difference. In multiple regression analysis on the urinary and airborne BPA levels, UGT1A6, use of protective equipments and workplaces were significant variables.
CONCLUSIONS
The urinary BPA concentration was affected by the levels to which workers were exposed during their working time and was considered to be metabolized by UGT1A6.
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Citations
Citations to this article as recorded by  - Filling gaps between exposure modeling and the analysis of urinary biomarkers using personal air monitoring: An intervention study of permethrin used in home insecticide spray
Seon‐Kyung Park, Heon‐Jun Lee, Eugene Song, Yerin Jung, Hyun Jung Yoo, Jeong‐Eun Oh, Hyeong‐Moo Shin, Jung‐Hwan Kwon
Indoor Air.2022;[Epub] CrossRef - Study Design, Rationale and Procedures for Human Biomonitoring of Hazardous Chemicals from Foods and Cooking in Korea
Seokwon Lee, Ryoung Me Ahn, Jae Hyoun Kim, Yoon-Deok Han, Jin Heon Lee, Bu-Soon Son, Kyoungho Lee
International Journal of Environmental Research and Public Health.2019; 16(14): 2583. CrossRef
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