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Overlap syndrome with Sjögren’s syndrome and systemic sclerosis in a steel rolling mill worker: a case report
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Min-Kee Yi, Won-Jun Choi, Sung-Woo Han, Seng-Ho Song, Dong-Hoon Lee, Sun Young Kyung, Sang-Hwan Han
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Ann Occup Environ Med 2016;28:24. Published online June 2, 2016
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DOI: https://doi.org/10.1186/s40557-016-0106-3
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Abstract
PDFPubReaderePub
- Background
There are few reports about work-related factors associated with Sjögren’s syndrome. We report a case of overlap syndrome with Sjögren’s syndrome and systemic sclerosis. Case presentationA 54-year-old man was admitted due to dyspnea on exertion. The results of physical examination and laboratory findings were compatible with Sjögren’s syndrome with systemic sclerosis. The patient had no pre-existing autoimmune disease, and denied family history of autoimmune disease. The patient worked in the large-scale rolling department of a steel manufacturing company for 25 years. Hot rolling is a rolling process performed at between 1100 °C and 1200 °C, generating a high temperature and a large amount of fumes, involving jet-spraying of water throughout the process to remove the instantaneously generated oxide film and prevent the high generation of fumes. In this process, workers could be exposed to silica produced by thermal oxidation. Other potential toxic substances including nickel and manganese seemed to be less likely associated with the patient’s clinical manifestations. ConclusionsOccupational exposure to silica seemed to be associated with the patient’s clinical manifestations of overlap syndrome with Sjögren’s syndrome and systemic sclerosis. Although the underlying mechanism is still unclear, autoimmune disease including Sjögren’s syndrome affects women more often than men and there was no family history of autoimmune disease. These suggested that there was an association between occupational silica exposure and the disease of the patient. Future research about the association between long-term low dose exposure to silica and the development of autoimmune diseases should be encouraged.
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Citations
Citations to this article as recorded by
- Environmental pollutants and phosphoinositide signaling in autoimmunity
Chang Ren, Noah D. Carrillo, Vincent L. Cryns, Richard A. Anderson, Mo Chen Journal of Hazardous Materials.2024; 465: 133080. CrossRef - Silicosis y síndrome de Sjögren
Miguel Martín Asenjo, Javier Miguel Martín Guerra, Claudia Iglesias Pérez, José María Prieto de Paula Archivos de Bronconeumología.2019; 55(10): 536. CrossRef - Silicosis and Sjögren's Syndrome
Miguel Martin Asenjo, Javier Miguel Martín Guerra, Claudia Iglesias Pérez, José Maria Prieto de Paula Archivos de Bronconeumología (English Edition).2019; 55(10): 536. CrossRef - Systemic sclerosis due to crystalline silica exposure among jewelry workers in Korea: two case reports
Jae Yoon Kim, Sang Yoon Do, Young Hoon Moon, Chul Gab Lee, Yun Sung Kim, Byung Soon Choi, Eun-A Kim, Han Soo Song Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
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A Case of Bronchiolitis Obliterans after Exposure to Nitrogen Dioxide
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Su Yeon Cheon, Yu Jin Kim, Sun Young Kyung, Sang Pyo Lee, Jeong Woong Park, Sung Hwan Jeong
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Korean Journal of Occupational and Environmental Medicine 2010;22(1):64-68. Published online March 31, 2010
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DOI: https://doi.org/10.35371/kjoem.2010.22.1.64
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Abstract
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- INTRODUCTION: Irritant gases and aerosols are capable of inducing acute, irritant lung injury. Lung injury caused by the inhaling nitrogen dioxide (NO2) has been known as silo-filler's disease in western countries. In Korea, acute pulmonary edema after NO2 inhalation in an industrial environment has been reported. We report here on a case of bronchiolitis obliterans after inhalation of NO2.
CASE REPORT: A 54-year-old male was admitted to the hospital with dyspnea and fever. Three weeks perviously, he was diagnosed with acute pulmonary edema after occupational exposure of NO2 and he was treated with corticosteroid for 2 weeks. After cessation of the corticosteroid, he developed dyspnea and fever. High resolution computed tomography (HRCT) showed ill-defined centrilobular nodules and patterns of mosaic perfusion; this all suggested air-trapping due to bronchiolitis obliterans. We diagnosed the patient as having bronchiolitis obliterans after acute pulmonary edema due to NO2 inhalation. The corticosteroid treatment was restarted and continued for 8 weeks. CONCLUSION NO2 induced lung injuries have variable clinical features. Close observation is needed for 6 to 8 weeks because recurrence with bronchiolitis obliterans may be seen several weeks later.
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Citations
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- Analysis of NO2over the Korean Peninsula from Ozone Monitoring Instrument Satellite Measurements
Deok-Rae Kim, Won-Jun Choi, Joon-Suk Lee, Seung-Yeon Kim, Jun-Suk Hong, Chang-Keun Song, Jae-Bum Lee, You-Deog Hong, Suk-Jo Lee Journal of Korean Society for Atmospheric Environment.2012; 28(3): 249. CrossRef
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