Annals of Occupational and Environmental Medicine

Suk Kwon Suh

4 Articles

Effect of air pollution on daily mortality in Daegu (1993~1997): Mi Young Lee, Choong Won Lee, Suk Kwon Suh; Korean Journal of Occupational and Environmental Medicine 2000;12(2):235-248. Published online June 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.2.235

OBJECTIVES
In order to evaluate the relationship between daily mortality and air pollution in Deagu for the period by the data from January 1993 to December 1997.
METHODS
Deaths from accident(International Classification of Disease, Revision 9; 800-999 and Revision 10; V01- Y89) were excluded, Daily counts of deaths were analysed by general additive poisson model on the current day to 5 days before death, with controlling for effects of year, season, weather, weekday and holiday. The air pollutants examined included total suspended particulate (TSP), sulfur dioxide (SO,), nitrogen dioxide (NO,), carbon monoxide (CO) and ozone (03).
RESULTS
Mortality was associated with NO, SO and CO in the air. Total mortality was estimated to increase by 1. 6 % (95 % CI 0. 3-3 %) with each 10 ppb rise in NOy on the current day and the preceding 1 day, 9. 4 % (95 % CI 7 13 %) with each 100 ppb rise in SOy and 2. 7 % (95 % CI 0. 1 5 %) with each 1 ppm rise in CO on the current day. The NO was more evident for the elderly who were 65 years and more. Cardiovascular-specific mortality was associated with the levels of CO on the current day. Respiratory-specific mortality was associated with the levels of TSP and NO 5 days before death. Excess mortality risk is clearly evident in the upper range of NO levels and increased monotonically with NO.
CONCLUSIONS
This study suggested that the air pollution status below the current Korean ambient air quality standard might have an adverse effect on daily mortality. Then, it is impertive that the strategy for control of the air pollution-related daily mortality should be developed.

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Review of Epidemiological Research and Perspectives for Future Environmental Health Progress in Korea
Kyoung-Mu Lee, Moon-Young Park
Journal of Environmental Health Sciences.2022; 48(3): 138. CrossRef

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Effect of Cadmium and Zinc on IL-6 Secretion in a Human Monocytic Cell Line, THP-1: Dong Hoon Shin, Suk Kwon Suh, Seong IL Suh; Korean Journal of Occupational and Environmental Medicine 1999;11(3):332-339. Published online September 30, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.3.332

Abstract PDF: OBJECTIVES
This study was performed to investigate effects of cadmium and zinc on IL-6 secretion using human monocyte in a culture system.
METHODS
We have used frypan blue dye exclusion methods to examine the effect of cytotoxicity of CdCl2, ZnCl2 in THP-1 cells. IL-6 was measured by the ELIBA method in the cell culture supernatants and the expression of IL-6 mRNA was examined by reverse transcription-polymerase chain reaction.
RESULTS
IL-6 production by THP-1 cells were decreased at 0.1 mM cadmium concentration(p < 0.05) and increased as zinc concentration increased. Zinc prevented cadmiuminduced suppression of IL-6. and the addition of a chelating agent, EDTA, restores IL-6 secretion. The expression of IL-6 mRNA decreased at 0.08 mM and 0.1 mM cadmium concentrations.
CONCLUSION
This results suggests that cadmium depressed production and gene expression of IL-6 in stimulates human monocytes, and zinc prevented cadmium-induced suppression of IL-16.

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Effect of Cadmium on Cytokine Gene Expression in a Human Monocytic Cell Line, THP-1: Mi Jung Kang, Seon Hee Yang, In Sung Chung, Dong Hoon Shin, Kwan Kyu Park, Suk Kwon Suh; Korean Journal of Occupational and Environmental Medicine 1997;9(2):320-331. Published online June 30, 1997; DOI: https://doi.org/10.35371/kjoem.1997.9.2.320

Abstract PDF: Cadmium, a potent toxic metal, poses a serious environmental threat but the mechanism of its toxicity remains unclear. Also, cadmium is a known immunotoxic agent in animal studies and induces pathophysiological effects by modulating components of immune system. Cytokines are being increasingly recognized as essential mediators of normal and pathologic immune response. Cells of mononuclear phagocytic system are strategically located at portals of entry in humans and therefore may be particularly at risk for cadmium exposure through contaminated air, food, and drinking water. In the present study, we investigated the effect of cadmium cytotoxicity for the monocyte and expression of cytokine gene in the control and cadmium treated human monocytic cell lines using RT-PCR method. The results showed that cadmium inhibited cell proliferation at 0.1mM cadmium treated cells for 24 hours. The TNF-alpha mRNA was expressed in both control and cadmium treated cells but not IL-6 and IL-1 beta The mRNA levels of TNF-alpha were examined during 24 hours culture period, at different time points. The expression of TNF-alpha mRNA increased in both 0.01mM and 0.1mM cadmium treated cells, but did not show dose-response relationship. According to cadmium treated duration, expression of TNF-alpha mRNA was more decreases in 24 hours than 6 hours. The decreased levels of mRNA of TNF-alpha that cadmium suppresses iris production at the transcription level.

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Lifestyle Variables Associated with Anemia in Female Workers: Choong Won Lee, Won Cheol Cho, Mi Young Lee, Suk Kwon Suh, Gui Yeon Kirn, Hae Won Shin; Korean Journal of Occupational and Environmental Medicine 1996;8(1):73-84. Published online February 29, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.1.73

Abstract PDF

The study was conducted from May to July in 1995 to investigate lifestyle variables associated with anemia in some female workers of the six large plants in Taegu. Cases were selected by a doctor based on symptoms and physical exmination and controls were matched according to age limits (?) and plant employed. The final subjects analyzed were 385 excluding. 36 who had underlying diseases associated with anemia or many missing values. Anemia was defined by the blood hemoglobin level less than 12 g/dL. Anemic subjects were 190(49.4%) with nonsignificant age distribution between cases and controls. Univariate logistic regression showed that there was no statistically significant difference in sociodemographic and occupational variables. Number of pad used during menstruation (odds ratio, OR=1.03, 95% Confidence interval ei,1.00-l-1.05) was the only significant among the menstruation-related variables. None of the lifestyle variables were significant but those who consume more than 4 cups of coffee a day vs. none and animal iron intake showed borderline statistical significance with the ORs 2.60 and 0.99, respectively. After controlling for marital status, native place and number of pad with the multiple logistic regression, those who consume more than 4 cups of coffee a day vs. none showed statistically significant OR 2.93(95% CI 1.01-8.49). Animal iron intake and diet to lose weight indicated borderline significance with ORs 0.99(p=0.06) and 1.47(p=0.09), respectively. These results suggest that there are some anemia-associated lifestyle variables and these variables may be important for the behavior modification to prevent anemia in female workers.

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Association of Coffee or Green Tea with Ferritin or Hemoglobin in Premenopausal Women
Dagyeong Lee, Wonyoung Jung, Dong Wook Shin
Korean Journal of Family Medicine.2023; 44(2): 87. CrossRef

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