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Urinary Cotinine Concentrations of Cases with Green Tobacco Sickness
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Kwan Lee, Hyun Sul Lim, Heon Kim, Si Hyun Nam
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Korean Journal of Occupational and Environmental Medicine 2004;16(4):413-421. Published online December 31, 2004
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DOI: https://doi.org/10.35371/kjoem.2004.16.4.413
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Abstract
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- OBJECTIVES
This study was carried out to measure the urinary cotinine concentrations of Korean tobacco harvesters with green tobacco sickness (GTS). METHODS We conducted a questionnaire survey and measured the urinary cotinine concentrations among the cases who visited six health subcenters and the emergency room in the Health Center and County Hospital after harvesting tobacco leaves in Cheongsong-gun, from Jul 15 to Aug 15, 2002. Ten suspected GTS cases were compared to 10 controls matched for residence, age, and sex. Urinary cotinine was analyzed with a reverse-phase high performance liquid chromatography (HPLC) system and expressed as geometric mean and standard deviation. The data collected were evaluated using the SPSS/win statistical package and the urinary cotinine concentrations between the two groups were analyzed by Mann-Whitney U test. RESULTS In both the 10 cases and controls, there were 3 males and 7 females. Ages ranged from 22 to 70 years old. Half of the cases were reported within the 6 hours between 12:00 pm and 17:59 pm. The median time from starting work to initially feeling ill was 4.3 hours (min. 2.5; max. 11.0). The GTS symptoms reported were nausea in 10 cases (100.0%), dizziness in 9 (90.0%), weakness in 8 (80.0%), headache in 7 (70.0%) and other symptoms. The geometric mean of urinary cotinine concentrations was significantly higher (p<0.01) in cases at 497.6 +/- 2.5 ng/ml (min. 73.1; max. 2,574.3) than in controls at 32.7 +/- 1.8 ng/ml (min. 13.3; max. 76.9). CONCLUSIONS Our study suggests that many tobacco harvesters may suffer from GTS in Korea. Therefore, it is very important for doctors to diagnose exactly the GTS. Also we must develop the methods which can prevent GTS, and simple methods of analysis for urinary cotinine.
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Citations
Citations to this article as recorded by
- Green Tobacco Sickness Among Tobacco Harvesters in a Korean Village
Sung-Jun Park, Hyun-Sul Lim, Kwan Lee, Seok-Ju Yoo Safety and Health at Work.2018; 9(1): 71. CrossRef - Nicotine Exposure in Green Tobacco Harvesters
Yun-Keun Lee, Won Kim, In-Ja Choi Korean Journal of Environmental Health Sciences.2010; 36(3): 208. CrossRef
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Effects of Number and Method of Visual Stimuli on Simple Reaction Time
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Jee Sung Kim, Sung Ah Kim, Chae Yong Lee, Soon Woo Park, Si Hyun Nam, Jong Young Lee, Ji Yeon Son
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Korean Journal of Occupational and Environmental Medicine 1996;8(3):477-489. Published online December 31, 1996
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DOI: https://doi.org/10.35371/kjoem.1996.8.3.477
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Abstract
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- In. order to evaluate the effects of number and method of visual stimuli on simple reaction time and determine the proper number of trials, simple reaction time of the computerized test of NTOS (Neurobehavioral Test for Occupational Screening) was carried out on 240 medical students. The prominent difference was found between male and female on simple reaction time. Regarding the effect of number based on the parameters of measures and the purpose of test itself, 64 trials was considered as proper number. The mean reaction time was different according to the methods of visual stimuli, such as color and size(p<0.05). The larger and more intence visual stimuli were, the faster sim-ple reaction time was. In respect to sex, that difference was similar. But, there was no difference depending upon whether the each result of each trial was showed on the monitor. The subjects, however, showed much interest when the result showed. Further studies, including the various variables on visual stimuli, are required to compare among various studies.
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Citations
Citations to this article as recorded by
- Performance assessment on the Korean Computerized Neurobehavioral Test using a mobile device and a conventional computer: an experimental study
Young Seok Byun, Sung Kyu Park, Joon Sakong, Man Joong Jeon Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef
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