Annals of Occupational and Environmental Medicine

Se Hoon Lee

15 Articles

A Validation of the Korean Version of QEESI(c) (The Quick Environmental Exposure and Sensitivity Inventory): Byoung Hak Jeon, Se Hoon Lee, Hyoung Ah Kim; Korean Journal of Occupational and Environmental Medicine 2012;24(1):96-114. Published online March 31, 2012; DOI: https://doi.org/10.35371/kjoem.2012.24.1.96

OBJECTIVES
A standardized questionnaire is not available for use as a screening tool to assess individuals with MCS/IEI in Korea. The QEESI(c), originally developed by Miller & Prihoda in 1998, helps researchers, doctors, and their patients identify individuals with MCS/IEI. Therefore, this study was conducted in order to create a Korean version of the QEESI(c) and evaluate whether this Korean version could be used as an effective MCS/IEI screening tool in Korea.
METHODS
The Korean version of the QEESI(c) was developed using a six-step approach: permission, forward translation, the first quality control, backward translation, cognitive debriefing and the second quality control, final proof reading. In order to collect data, we have done a sample survey in certain parts of Korea. A household was used as the sampling unit; we extracted random samples in each survey cluster and then interviewed two adults over 19 years of age living in each sampled household. A total of 300 subjects were recruited from the general population in local community. The factor structure in the Korean version of the QEESI was analyzed with 40 items on four sub-scales except for the 10 items in masking index using principal components analysis with Varimax rotation. A convergent validity test two sub-scales: chemical intolerance and symptom severity. We carefully compared the chemical intolerance with Nordin's chemical sensitivity scale and the symptom severity with Cho's subjective symptom score.
RESULTS
The results showed that the 40 items on the four sub-scales,' chemical intolerances',' symptom severity', 'life impact', and 'other intolerances', were consistent with those reported for the US population by Miller and Prihoda. The convergent validity wes very good (r=0.4; p<0.001, r=0.5; p<0.001, respectively). A good internal consistency (Cronbach' alpha=0.86~0.96) and test-retest reliability (r=0.87~0.90) were found in all scales, except for the internal consistency in the masking index.
CONCLUSIONS
The Korean version QEESI(c) showed a good reliability and validity. It should be necessary to conduct a MCS/IEI study adopting Korean version QEESI(c).

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What initiates chemical intolerance? Findings from a large population-based survey of U.S. adults
Claudia S. Miller, Raymond F. Palmer, David Kattari, Shahir Masri, Nicholas A. Ashford, Rodolfo Rincon, Roger B. Perales, Carl Grimes, Dana R. Sundblad
Environmental Sciences Europe.2023;[Epub] CrossRef
Does improving indoor air quality lessen symptoms associated with chemical intolerance?
Roger B. Perales, Raymond F. Palmer, Rudy Rincon, Jacqueline N. Viramontes, Tatjana Walker, Carlos R. Jaén, Claudia S. Miller
Primary Health Care Research & Development.2022;[Epub] CrossRef
Disease comorbidities associated with chemical intolerance
RaymondF Palmer, Tatjana Walker, RogerB Perales, Rodolfo Rincon, CarlosRoberto Jaén, ClaudiaS Miller
Environmental Disease.2021; 6(4): 134. CrossRef
Three questions for identifying chemically intolerant individuals in clinical and epidemiological populations: The Brief Environmental Exposure and Sensitivity Inventory (BREESI)
Raymond F. Palmer, Carlos R. Jaén, Roger B. Perales, Rodolfo Rincon, Jacqueline N. Forster, Claudia S. Miller, Wen-Jun Tu
PLOS ONE.2020; 15(9): e0238296. CrossRef
MCS/IEI Prevalence Rate of Workers Around an Accidental Release of Hydrogen Fluoride in Gumi Industrial Complex
Hye-Ji Han, Kuck-Hyeun Woo, Sung-Yong Choi, Byoung-Hak Jeon, Sangjun Choi
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(4): 534. CrossRef
Allergic Diseases and Multiple Chemical Sensitivity in Korean Adults
Inchul Jeong, Inah Kim, Hye Jung Park, Jaehoon Roh, Jung-Won Park, Jae-Hyun Lee
Allergy, Asthma & Immunology Research.2014; 6(5): 409. CrossRef

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Assessment of Neurobehavioral Performance Among Rotogravure Printing Workers Exposed to Toluene: Soo Young Chung, Seong Kyu Kang, Dae seong Kim, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 2004;16(2):115-128. Published online June 30, 2004; DOI: https://doi.org/10.35371/kjoem.2004.16.2.115

Abstract PDF

OBJECTIVES
The aims of this study were to investigate the occupational exposure level to toluene among rotogravure printers and neurobehavioral effects among them.
METHODS
Fifty rotogravure printers and 147 controls participated in this study. Environmental and biological monitoring was performed for the investigation of toluene exposure level, and neurobehavioral performance test were performed by using the Behavioral Assessment and Research System with Korean language instructions(BARS-K).
RESULTS
The major results were as follows; 1. Geometric mean toluene concentrations in the ambient air of 5 rotogravure printing workplaces were 10.5 (GSD 5.9)~181.9 (GSD 17.7), with a grand total of 56.7 (GSD60.9) ppm. 2. The geometric mean urinary hippuric acid level for rotogravure printers of 5 workplaces were 0.31 (GSD 0.11)~5.14 (GSD 0.55), with the grand total of 1.87 (GSD 2.06) g/g creatinine. 3. There was a linear correlation between hippuric acid levels in urine and the exposed toluene in air: urine hippuric acid (g/g creatinine)=0.03 toluene (ppm) + 0.15 (r=0.899, p<0.01, n=50). 4. After adjustment for confounders, significant associations were found between toluene exposure and Digit span forwards, Digit span backwards, Tapping preferred hand, Symbol digit and Selective attention trials.
CONCLUSIONS
1. Rotogravure printers were occupationally exposed to relatively high concentration to toluene, and their neurobehavioral performances were decreased. 2. The BARS neurobehavioral testing program, which minimizes the use of text in the instructions, was very effective in overcoming the cultural barriers in neurobehavioral testing.

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Evaluation of environmental and biological monitoring methods for toluene exposure assessment in paint industry
Mansour A. Balkhyour, Radhouane Chakroun, Faycal Faidi
Saudi Journal of Biological Sciences.2023; 30(2): 103538. CrossRef

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Effect of Job Stress and Coping Strategy on Job Satisfaction in a Hospital Works: Mi Hee Nam, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 2003;15(1):1-11. Published online March 31, 2003; DOI: https://doi.org/10.35371/kjoem.2003.15.1.1

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OBJECTIVE: The purpose of this study was to find out the effect of job stress, and the coping strategy of hospital workers on job satisfaction.
METHODS
468 self-administered questionnaires, were obtained from 120 doctors, 194 nurses, 45pharmacists and 109 administrators at a university hospital located in Seoul. The sociodemographic characteristics, personality types, degree of social support, job stresses, coping strategies, and job satisfaction were all assessed from the questionnaires.
RESULTS
The analysis of job stress, according to occupation, showed that the most important job-related stress-inducing factors were: for doctors, role overload, and poor advancement opportunity; for nurses, role overload, and career development and wages; for pharmacists, role overload and lack of recognition from other health professionals; and for administrators, career development and wages, and organizational inefficiency. Job satisfaction had a significant positive correlation with control strategy, and a negative correlation with role ambiguity, career development and wages, personal relationship, role overload, and symptom management strategy. Job satisfaction was significantly influenced by control strategy, occupation, role ambiguity, person with an 'A' type personality and gender, from a multiple regression analysis.
CONCLUSION
The results of this study suggested that to increase the job satisfaction for hospital workers, they need to be encouraged to use control strategies; create a supportive hospital atmospheres for social supports; re-evaluation, structuring and a new job design are all required to reduce role ambiguity.

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The Influence of Violence Experience on the Job Stress among Hospital Employees Working at Administration and Discharging Department
Yun-young Choi, Mi Ah Han, Jong Park, Seong Woo Choi
Health Policy and Management.2016; 26(4): 325. CrossRef
The comparative study on changes in job satisfaction and turnover intention according to the convergence mediating factors and the level of emotional labor in dental hygienists
Mi-sook Choi, Dong-ha Ji
Journal of the Korea Convergence Society.2015; 6(6): 27. CrossRef
Moderating Effect of Stress Coping Strategies on the Relationship between a National Statistics Office Workers' Occupational Stress and Mental Health
Yuran Jeong, Bo-Hyun Yoon, Eun-Joo Oh, Je-Heon Song, Soo-Hee Park, Haran Jung, Moon-Doo Kim, Man-Ki Baek, Eun-Rak Son, Ja-Young Jung
Journal of Korean Neuropsychiatric Association.2015; 54(4): 587. CrossRef
Role Conflict Experience of Geriatric Nurse Practitioners
Se-Young Kim, Young-Ran Kweon
The Journal of the Korea Contents Association.2014; 14(6): 186. CrossRef
A Study on the Structural Impact of Job Stress on the Organizational Commitment and Customer Oriented Boundary Spanning Behavior of Hospital Employees
Hye-Young Park
The Journal of Digital Policy and Management.2013; 11(11): 603. CrossRef
Job Stress, Job Satisfaction, and Organizational Commitment of Customized Home Health Care Nurse
Chan Gyeong Park, Ki Soo Park, Young Sil Kang
Journal of agricultural medicine and community health.2013; 38(1): 39. CrossRef
Relationships among Nursing Activities, the Use of Body Mechanics, and Job Stress in Nurses with Low Back Pain
Keunja Jung, Soonrim Suh
Journal of muscle and joint health.2013; 20(2): 141. CrossRef
Relationship Between Job Stress and Turnover Intention Among Nurses in University Hospitals
Hyun-Ran Shin, Young-Chae Cho
Journal of the Korea Academia-Industrial cooperation Society.2013; 14(8): 3958. CrossRef
Prevalence of Low Back Symptom and Impact of Job Stress among Working Women as Clinical Nurses in University Hospitals
Kyung-Jae Lee, Joo Ja Kim, Jeung-Im Kim
Korean Journal of Women Health Nursing.2011; 17(5): 484. CrossRef

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Effects of the Workers' Recognition of the Restructuring to Their Psychosocial Well-being: Kyong Suk Kim, Kang Sook Lee, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 2003;15(1):26-36. Published online March 31, 2003; DOI: https://doi.org/10.35371/kjoem.2003.15.1.26

Abstract PDF

OBJECTIVES
To investigate the effects of recognition on the restructuring of the psychosocial well-being of the workers.
METHODS
302 employees were recruited by a stratified random sampling method, from a company located in Seoul, which undergoing an administrative evaluation, in 2001. Subjects were asked to fill out questionnaire sheet on their recognition of the restructuring, and were questions on their psychosocial well-being. A one-way ANOVA and a multiple regression analysis were used to analyze the data.
RESULTS
For the psychological well-being, the levels of social performance and self-confidence were significantly different relation to age, educational attainment, marital status, insecurity recogni-tion, and competency recognition. According to the result of the multiple regression analysis, the insecurity recognition was found to significantly affect the social performance and self-confidence, depression, sleep disturbance and anx-iety, general well-being and vitality, whereas the competency recognition affected the social perfor-mance and self-confidence, sleep disturbance and anxiety, and overall psychosocial well-being.
CONCLUSION
The insecurity and competency recognitions against the restructuring were found to be the major factors affecting the workers psychosocial well-being. It is suggested that a decreased worker's insecurity recognition of the restructuring, and the competency recognition for the workers psychosocial health needs require promoting.

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Effect of Job Insecurity on Job related Depression and Anxiety: Large- and Small-sized Company Employees
Yeongmi Ha, Hyunju Park
Korean Journal of Occupational Health Nursing.2016; 25(4): 329. CrossRef

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The Application of Biological Monitoring and Effects of Ethanol and Phenobarbital on Plasma Protein Adducts Formed in Rats Exposed to Benzidine: Chi Nyon Kim, Se Hoon Lee, Jaehoon Roh; Korean Journal of Occupational and Environmental Medicine 2002;14(4):353-363. Published online December 31, 2002; DOI: https://doi.org/10.35371/kjoem.2002.14.4.353

Abstract PDF: OBJECTIVES
The effects of ethanol and phenobarbital,which are known to affect metabolism of xenobiotics, on the formation of benzidine-and its metabolites-plasma protein adducts in rats administered benzidine were evaluated.
METHODS
The experimental rats were divided into the control,ethanol and phenobar-bital groups. The experimental groups (ethanol and phenobarbital group)were pretreated with ethanol (1g/kg)or phenobarbital (80mg/kg)24 hours prior to the oral administration of benzidine (0.5mmol/kg). Blood samples were obtained from the vena cava from 5 rats in each group; and at 30 min,3 h,6 h,9 h,12 h,24 h,48 h,72 h,96 h,and 144 h after the administration of benzidine using heparin treated syringes.The plasma protein levels were separated immediately after taking blood samples. The adducts were underwent basic hydrolysis to convert them into aromatic amines. The hydrolyzed benzidine, monoacetylbenzidine, and 4-aminobiphenyl were analyzed by reverse-phased liquid chro-matography with an electrochemical detector. The quantitative amount of the metabolites was expressed by the plasma protein binding index(PBI).
RESULTS
Similar to the hemoglobin adducts,the levels of the plasma protein adducts of the ethanol and phenobarbital groups (benzidine-, monoacetylbenzidine-, and 4-amino-biphenyl-PBI)were higher than those of the control group. These results are attributable to the fact that ethanol and phenobarbital induced to the plasma protein adduct formation. The N-acetylation ratio in the control group was highest at 72 h with 2.34.In the ethanol group,it was highest at 72 h with a ratio of 2.46 and was highest in the phenobarbital group at 72 h with a ratio of 2.43. The N-acetylation ratio of the plasma protein adducts was relatively lower than that of the hemoglobin adducts.The level of the plasma protein adduct increased more rapidly than the hemoglobin adducts in all experimental groups regardless of the pretreatment,and decreased rapidly after reaching the maximum level.
CONCLUSION
The above results indicate that ethanol and phenobarbital increased the level of plasma protein adduct formation. The plasma protein adducts tended to decrease more rapidly than the hemoglobin adducts in the body after benzidine exposure. This results in this study result suggests that the effects of ethanol or phenobarbital need to be considered in the biochemical monitoring,and that the level of the plasma protein adducts be a more proper biomarker than the hemoglobin adducts for assessing the short term exposure to a benzidine and benzidine based dye.

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Effects of Stem Cell and Myeloperoxidase on Sister Chromatid Exchanges and Micronuclei Induction of Peripheral Lymphocytes by Styrene, Hydroquinone and Trichloroethylene: Kyung Jae Lee, Hyoung Ah Kim, Min Jung Shin, Jae Hyug Sung, Chung Yill Park, Hoon Han, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 2001;13(3):315-324. Published online September 30, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.3.315

Abstract PDF: OBJECTIVES
The objective of this study was to identify the possible role of stem cell and myeloperoxidase (MPO) in the metabolic activation of styrene, hydroquinone and trichloroethylene, by investigating the effects of stem cell from umbilical cord blood and MPO on the frequency of sister chromatid exchange (SCE) and micronuclei (MN) induction in cultured human peripheral lymphocytes exposed to these chemicals.
METHODS
Isolated lymphocytes from whole blood were cultured for 72 hours. The cells were treated with 1.50 mM styrene, 50 microM hydroquinone and 1.50 mM trichloroethylene dissolved with acetone (30 microl in total volume) at 24 hours after the beginning of culture. Control group was treated with acetone only. Immediately after adding these chemicals, 1.3X1 06 cells/ml and 2.6X1 06 cells/ml stem cell or 1.0 and 2.0 unit MPO with H2O2 (for substrate) were added to the cultures. Slides were stained with Giemsa's solution, and acridine orange for sister chromatid exchange, and for micronucleus analysis, respectively.
RESULTS
The results were as follows: 1) Myeloperoxidase and stem cell did not significantly affect the frequencies of SCE or MN in the control group. 2) The frequency of SCE or MN with exposure to styrene did not different from control in the absence of stem cell or MPO. Sister chromatid exchange induced by styrene was significantly increased by adding stem cell or MPO in dose-dependent relationship. The frequency of MN induced by styrene significantly increased in the presence of 2.0 unit MPO. 3) The frequency of SCE was significantly increased with exposure to hydroquinone than acetone treated control in the absence of stem cell or MPO. Sister chromatid exchange induction by hydroquinone significantly increased dose-dependently in the presence of stem cell or MPO. There was a tendency of increase of the MN frequency induced by hydroquinone in the presence of stem cell or MPO, but not significant. 4) It was found that trichloroethylene itself did not increase SCE or MN frequency. Frequency of SCE induced by trichloroethylene was significantly increased with adding stem cell (low and high) and 2.0 unit MPO. Even though stem cell or MPO increased the frequency of MN of lymphocyte exposed to trichloroethylene, the difference was not significant.
CONCLUSIONS
Authors found that the frequencies of both sister chromatid exchange and micronucleus induced by styrene, hydroquinone, and trichloroethylene were increased significantly with the treatment of stem cell or myeloperoxidase. It was suggested that myeloperoxidase may therefore play an important role in the metabolic activation of styrene, hydroquinone, and trichloroethylene and myeloperoxidase probably be involved in the myelotoxicity of these chemicals.

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A Study of Relationship between Exposure to Manganese Chloride and Malondialdehyde in Rat Tissues: Chul Jin Moon, Soo Jin Lee, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 2000;12(3):338-345. Published online September 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.3.338

Abstract PDF: OBJECTIVES
This research was intended to investigate the relationship between manganese and malodndialdehyde concentration in tissues of rats exposed to maganese chloride.
METHODS
The study groups were 12 manganese treated rats and 9 control rats. Manganese treated rats were given intraperitoneally manganese chloride (Mn, 4 mg/kg) daily for a period of 30 days except Sunday. Control rats were injected 1ml of saline. The plasma manganese concentrations of rats were determined by graphite furnace atomic absorption spectrometry. The tissue manganese concentration was determined by flame atomic absorption spectrometry. Malondialdehyde, the product of lipid peroxidation was determined by ultraviolet-visible spectrophotometry. The plasma malondialdehyde was determined by gas chromatography with mass-detector. Protein concentration was quantified by ultraviolet-visible spectrometry and was used for the compensation of tissue malondialdehyde and manganese concentration.
RESULTS
Manganese concentrations of plasma, brain, liver, and pancreas were very significantly higher in the manganese-treated rats than in the control rats. Malondialdehyde concentration of plasma, brain, and pacrease were significantly higher in the manganese-treated rats than in the control rats. The concentration of malondialdehyde was correlated with manganese levels in plasma, brain and pancreas.
Conclusion
Based on the results obtained as above, it was concluded that the malondialdehyde, product of lipid peroxidation was related to the cell death due to dosing excess manganese.

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Effects of Genetic Factor, Life Styles, and Diet on Urinary Hippuric Acid Excretion in Toluene Exposed Workers: Hyeon Woo Yim, Chung Yill Park, Young Man Roh, Kang Sook Lee, Jung Min Lee, Won Chul Lee, Se Hoon Lee, Chee Kyung Chung; Korean Journal of Occupational and Environmental Medicine 2000;12(3):405-420. Published online September 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.3.405

Abstract PDF

OBJECTIVES
The purpose was to investigate the distributions and the effects of genetic polymorphism of aldehyde dehydrogenase 2(ALDH2), cytochrome P450 1A1(CYP1A1), and cytochrome P450 2E1(CYP2E1) on the toluene metabolism.
METHODS
The subjects consisted of 160 workers who were exposed to toluene in different industries such as paint manufacturing, painting on steel and wood products, printing, bonding, and coating. The exposed toluene level was monitored by passive air sampler, and the questionnaire variables were age, sex, smoking, drinking, previous nights drinking, use of personal protective equipment, work duration, and taking benzoic acid containing food. The urinary hippurric acid collected in the end of shift was corrected by urinary creatinine concentration. The genotypes of ALDH2, CYP1A1, and CYP2E1 were investigated using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) methods with DNA extracted from venous blood.
RESULTS
The geometric mean and the geometric standard deviation of urinary hippuric acid concentration were 0. 44 g/g creatinine and 2. 80. The urinary hippuric acid concentration was significantly related to personal exposed toluene level among personal exposed toluene level, use of personal protective equipment, and benzoic acid containing food diet. The slope differences of the regression for ALDH2, CYP1A1, and CYP2El genetic polymorphism, age, smoking, and work duration tended to be significant. In multiple regression analysis, the regression coefficient of toluene, ALDH2, CYP1A1, CYP2E1 genetic polymorphism were significant.
CONCLUSIONS
Prom the above results, urinary hippuric acid level after toluene exposure was significantly affected by the genetic polymorphism of ALDH2, CYP1A1, CYP2E1. It is needed further investigation of the urinary hippuric acid level considering the effect of genetic polymorphism.

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Applications of CYP-450 expression for biomonitoring in environmental health
Ho-Sun Lee, Mihi Yang
Environmental Health and Preventive Medicine.2008; 13(2): 84. CrossRef
Past and Future Applications of CYP450-Genetic Polymorphisms for Biomonitoring of Environmental Toxicants
Bitna Yi, Ji-Yeon Yang, Mihi Yang
Journal of Environmental Science and Health, Part C.2007; 25(4): 353. CrossRef

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Symptom Prevalence and Related Factors of Upper Limb Musculoskeletal Symptoms in Automobile Related Job Workers: Chul Soo Yoon, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 1999;11(4):439-448. Published online December 31, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.4.439

Abstract PDF

OBJECTIVES
The purpose of this study was to determine the prevalence and related factors of upper limb musculoskeltal symptoms among workers in automobile related jobs.
METHODS
Two-hundred and twenty-one workers were volunteered in this 'study consisting of 112 seat installers and 109 auto mechanics. A questionnaire was administered to the workers consisting of questions on demographics, work type and duration, sleep hours, health habits, and standardized descriptions of NJOSH on musculoskeletal symptoms.
RESULTS
Complaint rates of neck and upper extremity musculoskeletal symptoms by anatomical site were as follows: shoulder, 52.0%; neck, 47.1%; wrist and hand, 39.4 elbow, 26.2% and; arm, 24.4%. Significantly higher prevalence of shoulder musculoskele tal symptom was found in middle school than high school graduate, married than unmar ned, less than 6 hours sleep than over 6 hours sleep and, seat installer than auto mechanic group. A significantly higher prevalence of arm, elbow, hand and wrist mus loskeletal symptoms was disclosed in the less than 6 hours sleep than over 6 hours sleep group and the seat installer than the auto mechanic group. Multiple logistic regression analysis identified education, sleep hours and, job type as the main affecting factors for shoulder musculoskeletal symptoms. Sleep hours and job type were the main affecting factors for wrist and hand musculoskeletal symptoms. Sleep hours were the main affecting factors for arm and elbow musculoskeletal symptoms.
CONCLUSIONS
The prevalence of neck and upper limb musculoskeletal symptoms was high in workers who did routine tasks at confined places like seat install-line work. It is recommended that workers performing simple and routine tasks be provided adequate sleep time since lack of sleep was the main affecting factor for most upper limb mus loskeletal symptoms in automobile factory related jobs workers.

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Sleep duration mediates abdominal and lower-extremity pain after night work in nurses
Maria Katsifaraki, Kristian Bernhard Nilsen, Jan Olav Christensen, Morten Wærsted, Stein Knardahl, Bjørn Bjorvatn, Mikko Härmä, Dagfinn Matre
International Archives of Occupational and Environmental Health.2019; 92(3): 415. CrossRef
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Performance of Neurobehavioral Tests Among Welders Exposed to Manganese: Youngwoo Jin, Yangho Kim, Kyoo Sang Kim, Euna Kim, Young Sook Cho, Yong Chul Shin, Changho Chai, Younghyu Choi, Se Hoon Lee, Young Hahn Moon; Korean Journal of Occupational and Environmental Medicine 1999;11(1):1-12. Published online March 31, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.1.1

Abstract PDF

To study neurobehavioral effects for manganese fume exposure of welders, we administrated questionnaire about subjective symptom, related with manganese exposure. Neurobehavioral Core Test Battery of World Health Qrganization(NCTB) and finger tapping for 98 welders and 29 non-welding workers. We adopted welding duration as a criterion for exposure assessment, because of the lack of the longitudinal valid data and differences in airborne concentrations of manganese in welding types, such as shielded metal arc and CO2 arc welding. Neurologic, musculoskeletal and concentration symptoms were significantly increased by increase of welding duration. Performance of finger tapping preferred hand, Santa Ana dexterity test preferred hand and correct number of pursuit aiming were significantly decreased by increase of welding duration. These results comparable with previous studies that suggest neurobehavioral test, especially motor test, to be an appropriate tool to detect early neurobehavioral abnormalities related with manganeses exposure.

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State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk?
Annette B. Santamaria, Colleen A. Cushing, James M. Antonini, Brent L. Finley, Fionna S. Mowat
Journal of Toxicology and Environmental Health, Part B.2007; 10(6): 417. CrossRef
High signal intensity on magnetic resonance imaging as a predictor of neurobehavioral performance of workers exposed to manganese
Yong Chul Shin, Euna Kim, Hae-Kwan Cheong, Sungil Cho, Joon Sakong, Kyoo Sang Kim, Jung Sun Yang, Young-Woo Jin, Seong-Kyu Kang, Yangho Kim
NeuroToxicology.2007; 28(2): 257. CrossRef
Sequelae of fume exposure in confined space welding: A neurological and neuropsychological case series
Rosemarie M. Bowler, Sanae Nakagawa, Marija Drezgic, Harry A. Roels, Robert M. Park, Emily Diamond, Donna Mergler, Maryse Bouchard, Russell P. Bowler, William Koller
NeuroToxicology.2007; 28(2): 298. CrossRef
Issues in neurological risk assessment for occupational exposures: The Bay Bridge welders
Robert M. Park, Rosemarie M. Bowler, Donald E. Eggerth, Emily Diamond, Katie J. Spencer, Donald Smith, Roberto Gwiazda
NeuroToxicology.2006; 27(3): 373. CrossRef

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A Survival Case Sustained Pulmonary Damage After Paraquat Ingestion: Won Oh Choo, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 1996;8(2):223-227. Published online September 30, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.2.223

Abstract PDF: The rapid quantification of paraquat in body fluids is of undoubted value in both initial assesment as well as the immediate prognosis of acutely poisoned patients. A 20-year-old woman ingested a mouthful of paraquat. Serum and urine paraquat levels were measured colorimetrically for 48 hours after identifying the presence of paraquat in her urine by a Paraquat test kit. At that time her survivability was considerd to be over 50% according to Proudfoot's scale of time related measured serum paraquat levels. Five days after admission, she began to cough but her chest x-ray picture was normal. However, she persisted to cough and subsequent chest x-rays showed fine reticulonodular densities in both upper and lower lobes. Twenty days after admission, she .was clinically well, and not deteriorated radiologically. Therefore, respiratory function tests were under-taken. They showed reduced lung volume, moderate reduction in ventilatory capacity, and a diffusion defect (DLco: 27% predicted value). Twenty four days after admission, the patient was discharged in good condition except for the sequale of lung involvement. Six months later, she was re-examined and found to be healthy with a large regression of lung lesions on her chest x-ray.

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A Study on the Handling Patterns of Anticancer Drugs and Related Symptoms in Nurses: Hae Sook Shin, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 1996;8(2):228-238. Published online September 30, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.2.228

Abstract PDF

To evaluate the subjective symptoms; among nurses handling anticancer drugs, we investigated symptom prevalence in 487 nurses exposed to anticancer drugs and 242 control nurses, who are working at 14 university hospitals in Korea by self-administered questionnaire. Safety regulations for handling anticancer drugs in these hospitals as well as the level of knowledge on safety .rules of them among nurses were also evaluated, The results were as follows: 1. Only 1.5% of nurses used. the biological safety cabinet always, 32.7% could not use it during evening time and on holidays, and 65.8% could not use at all since lack of it. When nurses prepared anticancer drugs, they wore gloves (49.1%), gown (7.2%), goggle (1.6%), and mask (11. 5%). And. 46.1% of them answered that they ate and drank in the anticancer drugs preparation room. 2. The level of knowledge on safety rules of anticancer drugs were generally low in both exposed (12.7/17 items) and control (12.7/17 items) group. The questions which nurses answered wrong exceeded fifty percent were: the possibility of exposing to anticancer drugs when they correct their make-ups; and when they handled body fluids of cancer patients. Only 20.3%. of the, nurses were acknowledged with the hours for the cancer patients' body fluids being considered to be contaminated after receiving chemotherapy. 3. The prevalence of allergic disease was higher in exposed group than in control group. Among 43 symptoms of total, the prevalence of 10 symptoms (nausea, skin rash, itching, chronic throat irritation, tachycardia, alopecia, skin hyper pigmentation, loss of libido, leukopema, thrombocytopenia) were higher in exposed group than in control group. 4. The prevalence of ten symptoms which showed higher prevalence in exposed group was significantly correlated with eating, and drinking in the preparation room for anti cancer drugs, the degree of skin contact with anticancer drugs, and the amount of anticancer handling them, and BML It was shown that eating and drinking in anticancer drug preparation room, and the amount of handling them, significantly affected the prevalence of 10 symptoms among nurses exposed after stepwise multiple regression analysis. The results of this study suggest that nurses handling anticancer drugs have potential risk of exposure to anticancer drugs, and the preventive measures for the protection of nurses' health be needed by education, and improvement of their working environment.

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Nurses’ Knowledge, Compliance and Exposure Experiences with Cytotoxic Drugs in a University Hospital
Bokyoung Kim, 윤지향, Kim,Myung-Hee, 이상림, 김성민
Global Health and Nursing (글로벌 건강과 간호).2016; 6(1): 11. CrossRef
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Ji Hyun Yun, Jeong Yun Park
Asian Oncology Nursing.2016; 16(4): 251. CrossRef
Health Effects of Chemicals used in hospitals among Healthcare Workers
Jong Uk Won
Journal of the Korean Medical Association.2010; 53(6): 474. CrossRef

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Performances of the WHO Neurobehavioral Core Test Battery among Mal Workers Occupationally Non-exposed to Neurotoxic Agents: Se Hoon Lee, Hyoung Ah Kim, Won Chul Lee, Seong Sil Chang, Kyung Jae Lee, Chung Yill Park, Chee Kyung Chung; Korean Journal of Occupational and Environmental Medicine 1995;7(1):139-151. Published online February 28, 1995; DOI: https://doi.org/10.35371/kjoem.1995.7.1.139

Abstract PDF: Five items among neurobehavioral core test battery of World Health Organization, including Santa Ana dexterity, pursuit aiming, digit symbol, simple reaction time, and Benton visual retention, were administered to the workers occupationally non-exposed to neurotoxic agents by operational guide for the WHO neurobehavioral core test battery. Subjects were volunteers from the industrial workers (117) and clerks (40). Detailed occupational history such as exposed agents including noise or vibration, educational level, residence, smoking and drinking habit were recorded. Most of the neurobehavioral tests were correlated with age and educational level. Smoking was correlated with pursuit aiming and digit symbol. Vibration affected pursuit aiming. Job type (industrial workers vs. clerks) and noise exposure did not affected among tested items. Multiple regression analysis was done for establishing predict equation to estimate normal ranges of the tests for male workers. Age was shown to be main independent variable affected for all tests except wrong dot of pursuit aiming. Educational level was also shown to affected most of the tests except Santa ana dexterity and wrong dot of pursuit aiming. Alcohol consumption affected Santa Ana dexterity, non-preferred hand, and smoking affected only wrong dot of pursuit aiming after multiple regression analysis.

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The Factors associated with Knowledge, Attitude and Practice Regarding Occupational Health Among Small and Medium Scale Industry Workers: Chung Yill Park, Kang Sook Lee, Won Chul Lee, Se Hoon Lee; Korean Journal of Occupational and Environmental Medicine 1994;6(1):42-55. Published online February 28, 1994; DOI: https://doi.org/10.35371/kjoem.1994.6.1.42

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This study was carried out to determine the knowledge(K), attitude(A) and practice(P) on major occupational health problems among small and medium scale industry workers in Kimpo area. We used self-administered questionnairs regarding the emergency treatment on accident, the management of hazardous materials, the work place hygiene, the health risk of young workers and female works, the use of protective device, prevention of occupational disease, the periodic physical examination and the occupational health administration. The results obtained were as follow; 1. There were significant differences among age groups on the KAP. The teenage group had the lowest scores. As the age increased, total mean scores of KAP were increased concurrently, and this trend was statistically significant. 2. There was significant differences between male and female subjects on total mean scores of knowledge. But on that of the attitude and practice, there was no significant difference between male and female subjects. 3. As the size of enterprise increased, the mean scores of knowledge, attitude and practice were increased, but this trend was not statistically significant. 4. As the work duration increased, the mean scores of the attitude and the practice were increased. But the mean scores of the knowledge did not show this trend. 5. The white collar workers had significant higher scores than blue collar workers on knowledge, but there were not significant differeneces on attitude and practice. 6. The significantly associated variables on knowledge were work status and sex. On attitude and practice, age and work duration were significantly associated variables, but the degree of association was low. 7. When stepwise multiple regression analysis was done, work status, sex, age were significantly attributed to knowledge, age and sex wwere attributed to attitude, and age was attributed to knowledge, but the coefficient of determination were very low. In conclusion in small and medium scale industry workers, there were weak or no effects of age, sex of enterprise, work duration and work status on knowledge, attitude and practice regarding occupational health. So, it is suggested that all the members of the workers should be included in health education program for the workers.

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Young Joong Kang, Jong Heun Park, Huisu Eom, Bohwa Choi, Seyoung Lee, Ji-Won Lee, Jun-Pyo Myong
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
A Predictive Model of Workers' Quality of Life
Bok-Im Lee, Hye-Sun Jung
Korean Journal of Occupational Health Nursing.2011; 20(1): 35. CrossRef

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A study on component analysis of organic solvents and their health effect: Young Man Roh, Se Hoon Lee, Hyun wook Kim, Kwang Mook Lee, Chee Kyung Chung, Seung Han Lee; Korean Journal of Occupational and Environmental Medicine 1993;5(1):88-103. Published online February 28, 1993; DOI: https://doi.org/10.35371/kjoem.1993.5.1.88

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No abstract available.

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Overview of occupational cancer in painters in Korea
Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef

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