Annals of Occupational and Environmental Medicine

Sang Je Jung

6 Articles

A Case of Exercise-induced Rhabdomyolysis with Hepatitis: Seong Ah Kim, Sang Je Jung, Chae Yong Lee, Bong Goo Ha, Ki Soo Park; Korean Journal of Occupational and Environmental Medicine 2006;18(1):67-72. Published online March 31, 2006; DOI: https://doi.org/10.35371/kjoem.2006.18.1.67

BACKGROUND
Rhabdomyolysis is a relatively rare disease caused by various factors and is characterized by skeletal muscle damage. While crush injury is the most common cause in Korea as well as other countries, overexertion is an important common cause among young men in daily life. Although exercise-induced rhabdomyolysis is already well published among athletes or military persons, there have been few reports in workers.
CASE
REPORT: We observed a 28-year-old male worker who had elevated liver transaminases during a periodic workers' health checkup. Although he did not exhibit the typical pattern of toxic hepatitis, we had to exclude any possibility of dimethylacetamide-induced hepatitis (DIH) because he had worked in a spandex-producing factory, which already had a history of many DIH cases over several years. We performed careful history taking, several laboratory tests, liver ultrasonography and liver biopsy. We also investigated the results of biological monitoring and air concentrations of dimethylacetamide. The findings from these examinations supported the clinical diagnosis of exercise-induced rhabdomyolysis with hepatitis.
CONCLUSION
This case demonstrates that exercise can induce rhabdomyolysis and hepatitis. This disease must be treated by prompt and appropriate management because it might develop more serious complications such as acute renal failure.

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Exercise-induced rhabdomyolysis mechanisms and prevention: A literature review
Jooyoung Kim, Joohyung Lee, Sojung Kim, Ho Young Ryu, Kwang Suk Cha, Dong Jun Sung
Journal of Sport and Health Science.2016; 5(3): 324. CrossRef
Literature review of effect of work pattern (day shift and night shift) on worker's health
Ki-Youn Kim, Man-Su Cho, Won-Mo Gal
Journal of the Korea Safety Management and Science.2013; 15(2): 1. CrossRef

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A Case of Toxic Hepatitis in a Worker Exposed to a Cleansing Agent Mainly Composed of Methylene Chloride: Bong Goo Ha, Jin Seok Kim, Jay Young Yu, Kuck Hyun Woo, Jung Oh Ham, Seong Yong Yoon, Yong Seok Jang, Sang Je Jung; Korean Journal of Occupational and Environmental Medicine 2004;16(2):210-219. Published online June 30, 2004; DOI: https://doi.org/10.35371/kjoem.2004.16.2.210

Abstract PDF

OBJECTIVES
To report a case of toxic hepatitis in a worker exposed to a cleansing agent mainly composed of methylene chloride.
METHODS
A 27-year-old female worker who had worked in an inspection and packing position of semiconductor parts in a factory using methylene chloride as a metal cleansing solvent was hospitalized due to fever, chill and generalized aches. We evaluated her with blood tests, abdominal ultrasonographic scan and abdominal CT scan and also took her occupational history.
RESULTS
The patient showed acute hepatitis in blood and radiologic tests after admission. The serologic tests for viral hepatitis A, B, C and autoimmune hepatitis were negative. She had no history of significant alcohol use, recent medication or drug allergy. After admission, her symptoms were improved and liver enzyme levels(AST and ALT) were markedly reduced. She returned to her workplace after discharge. Thereafter, however, her previous symptoms were recurred and she was hospitalized again 2 days after returning to her workplace. After this second admission, she showed acute hepatitis in blood tests and her symptoms were improved and liver enzyme levels were markedly reduced with the same pattern as those of the first admission. On the 11th day of the second admission, liver enzyme levels were normalized and she was discharged from hospital.
CONCLUSIONS
We presume that this patient`s liver injury was related to the methylene chloride presence at her workplace due to her clinical symptoms, blood tests, radiologic tests and occupational history.

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Death Due to Acrylic Adhesive (Dichloromethane): A Case Report
Ho Bong Hyun, Jo Youn Park, Hyeong Sin Park, Jeong Hyun Hong, Myung Guon Ko, Hyun Wook Kang, Hyoung Soo Lim
Korean Journal of Legal Medicine.2022; 46(4): 133. CrossRef
A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef
Occupational Hepatic Disorders in Korea
Hyoung Ryoul Kim, Tae Woo Kim
Journal of Korean Medical Science.2010; 25(Suppl): S36. CrossRef

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Ocular, Respiratory and Skin Symptoms Among Solderers Employed in Printed Circuit Board Assembly Units: Jay Young Yu, Kuck Hyeun Woo, Jin Seok Kim, Jung Oh Ham, Tae Sung Choi, Bong Goo Ha, Sang Je Jung, Shin Goo Park, Il Ryong Kim; Korean Journal of Occupational and Environmental Medicine 2001;13(4):423-435. Published online December 31, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.4.423

Abstract PDF

OBJECTIVES
This study was conducted to evaluate the prevalence of ocular, respiratory and skin symptoms among solderers and to investigate the relationship between symptom prevalence and exposure intensity.
METHODS
We analyzed 126 eligible participants out of a population of 146 male solderers who completed the symptom questionnaires. Fourteen symptoms including 'itchy and red eyes', 'itchy or prickly nose', 'sneezing', 'rhinorrhea', 'blocked nose', 'pricklythroat', 'foreign body sensation in throat', 'sudden bouts of coughing', 'exertional breathlessness ', 'wheezing', 'sputum production', 'itchy face or hands', 'acneiform eruptions on the face'and 'red spots on the face or hands'were contained. Blood lead levels of all the 126 participants were tested and the participants'own assessments of the health risk of soldering were collected.
RESULTS
Of the 14 investigated symptoms, 'sudden bouts of coughing'was significantly more prevalent in solderers who worked 4 hours or more a day than those who worked less than 4 hours a day, as for the other symptoms, there were no significant differences in the preva1ences related to daily soldering hours. 2.8% of the solderers considered the risk of flux exposure to be serious. The mean blood lead level was 6.05 microgram/dL (maximum 15.50 microgram /dL).
CONCLUSIONS
Soldering may increase the risk of respiratory symptoms. Further investigations on the hazards of soldering processes are warranted and solderers should be educated on these hazards.

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Skin Disease Among Staff in a Large Korean Nursing Home.
DEREK RICHARD SMITH, JAE-WOOK CHOI, DONG-SOO YU, MYUNG KI, CHUN-HWA OH, ZENTARO YAMAGATA
The Tohoku Journal of Experimental Medicine.2002; 198(3): 175. CrossRef

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Toxic Hepatitis Induced by Occupational Dimethylacetamide Exposure: Tae Sung Choi, Kuck Hyeun Woo, Jin Seok Kim, Wan Seup Park, Jung Ho Ham, Sang Je Jung, Jae Young Yu; Korean Journal of Occupational and Environmental Medicine 2001;13(2):164-170. Published online June 30, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.2.164

Abstract PDF

Dimethylacetamide is widely used in the production of plastics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid of dimethylacetamide(DMAC) can cause liver damage. Toxic hepatitis possibly attributable to DMAC exposure occurred in seven works among 178 employees who had worked on a new spandex-fiber production line. A large amount of DMAC is used as a spinning solvent for synthetic fibers in the factory. The patients were aged 23-47 years old and composed of five males and two females. They were involved in the process of polymerization(1 patient), spinning(1), take-up(4) and packaging(1). The mean duration of exposure was 10 weeks. They experienced fatigue, dizziness and jaundice. The patients showed elavated total bilirubin, alanine aminotransferase(ALT), and aspartate aminotransferase(AST) levels. The serologic test for viral hepatitis A, B and C were negative, as were the abdominal ultrasonographic scans. Based on the presumptive diagnosis of DMAC-induced toxic hepatitis, they were removed from the workplaces. One or two months after removal from the work, the transaminase levels returned to normal. The patients had no history of significant alcohol use, blood transfusion, recent medication, and drug abuse. As a result, authors could not find any attributable cause of toxic hepatitis but the toxicity by DMAC exposure.

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Intravenous Busulfan, Dimethylacetamide and neurotoxicity after high-dose pretransplant conditioning chemotherapy
J. Ramdial, K. H. Chan, G. Sanchez Petitto, B. Valdez, B. S. Andersson, Y. Nieto
Bone Marrow Transplantation.2023; 58(6): 635. CrossRef
A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef
A green approach to porous and dense antifouling membranes through solvent-free bulk polymerization
Runnan Zhang, Jinming Peng, Yanlei Su, Xiaochen Fan, Zhongyi Jiang, Xueting Zhao, Jiazhen Liu, Yafei Li, Jiaojiao Zhao
Chemical Engineering Science.2015; 135: 501. CrossRef
Grand Rounds: An Outbreak of Toxic Hepatitis among Industrial Waste Disposal Workers
Hae-Kwan Cheong, Eun A Kim, Jung-Keun Choi, Sung-Bong Choi, Jeong-Ill Suh, Dae Seob Choi, Jung Ran Kim
Environmental Health Perspectives.2007; 115(1): 107. CrossRef
Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers
C-Y Lee, S-J Jung, S-A Kim, K-S Park, B-G Ha
Occupational and Environmental Medicine.2006; 63(10): 688. CrossRef

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Related factors of high frequency hearing loss in the noise-exposed male workers: Sang Je Jung, Kuck Hyeun Woo, Wan Deup Park, Jae Young Yu, Tae Sung Choi, Sang Woo Kim, Jin Seok Kim; Korean Journal of Occupational and Environmental Medicine 2000;12(2):187-197. Published online June 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.2.187

Abstract PDF

OBJECTIVES
The purpose of the study was to assess the risk factors assumed to be related to the high frequency hearing loss in the noise-exposed male workers.
METHODS
712 occupationally noise-exposed male workers were included in this cross sectional study. The subjects filled out a questionnaire on the history of noise exposure, hearing protection, otologic diseases, tobacco smoking, and were tested on height, weight, hematocrit, serum total cholesterol level, fasting plasma glucose level and arterial blood pressure level. Pure tone audiometry and otoscopy were conducted and the subjects were allocated into two groups according to whether they had 4000 Hi hearing loss or not.
RESULTS
The multiple logistic regression analysis showed that military noise exposure, poor wearing status of the hearing protection devices, increased age, long noise exposure duration, mean arterial pressure less than 80mmHg, high fasting plasma sugar are the factors significantly related to high frequency hearing loss (P<0.05). On the contrary, there was no significant relationship between noise intensity, body mass index, serum total cholesterol level, smoking and high frequency hearing loss. Low hematocrit was shown to be a significant factor with a p-value less than 0.1.
CONCLUSIONS
High frequency hearing loss in the noise-exposed male workers is related to military noise exposure, use of hearing protection devices, age, noise exposure length, fasting glucose level and mean arterial pressure, in this order. Appropriate use of the hearing protection devices has a great impact on the prevention of the noise-induced hearing loss.

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The effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
Dae Yun Kim, A Ram Kim, Joo Hyun Sung, Choong Ryeol Lee, Jiho Lee
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef

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Two Cases of Convulsion Associated With Caprolactam: Kuck Hyeun Woo, Sang Je Jung, Wan Seup Park, Hea Ryeon Shin, Jin Seok Kim, Sang Woo Kim; Korean Journal of Occupational and Environmental Medicine 1998;10(1):116-120. Published online February 28, 1998; DOI: https://doi.org/10.35371/kjoem.1998.10.1.116

Abstract PDF: Two young men were seen with nausea, vomiting, dermatitis, seizure after two-four days of occupational exposure to caprolactam, a nylon fiber precursor. There were no significant results in laboratory test, brain CT, EEG except leukocytosis, hyperglycemia. Caprolactam has been shown to induce convulsive disorder in experimental animal studios and Tuma et al (1981) described that one worker acutely exposed to caprolactam developed generalized tonic-clonic seizure with leukocytosis. The coincidence of typical skin lesion with otherwise unexplained generalized tonic-clonic seizure in those young man strongly suggests that caprolactam was causal agent.

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