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Pneumoconiosis in a polytetrafluoroethylene (PTFE) spray worker: a case report with an occupational hygiene study
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Namhoon Lee, Kiook Baek, Soohyun Park, Inho Hwang, Insung Chung, Wonil Choi, Hyera Jung, Miyoung Lee, Seonhee Yang
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Ann Occup Environ Med 2018;30:37. Published online June 4, 2018
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DOI: https://doi.org/10.1186/s40557-018-0248-6
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Abstract
PDFPubReaderePub
- Background
Using analysis of air samples from the workplace, we report on one case of pneumoconiosis in an individual who has been working in a polytetrafluoroethylene (PTFE) spraying process for 28 years. Case presentationThe patient was diagnosed with granulomatous lung disease caused by PTFE using computed tomography (CT), lung biopsy and electron microscopy. To assess the qualitative and quantitative exposure to PTFE in workplace, Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX) and thermogravimetric analysis (TGA) were performed on air samples from the workplace. The presence of PTFE particles was confirmed, and the airborne concentration of PTFE was estimated to be 0.75 mg/m3. ConclusionsThis case demonstrates that long-term exposure to PTFE spraying can cause granulomatous lung lesions such as pneumoconiosis; such lesions appear to be caused not by the degradation products of PTFE from high temperatures but by spraying the particles of PTFE. Along with air-sampling analysis, we suggest monitoring the concentration of airborne PTFE particles related to chronic lung disease.
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Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Monice Fiume, Bart Heldreth International Journal of Toxicology.2023; 42(3_suppl): 144S. CrossRef - Occupational Lung Disease Caused by Exposure to Polytetrafluoroethylene
Ami Aoki, Akira Saito, Kenjiro Shima, Yosuke Kimura, Katsuaki Asakawa, Riuko Ohashi, Hajime Umezu, Takuro Sakagami, Hiroshi Moriyama, Toshiaki Kikuchi Internal Medicine.2022; 61(24): 3713. CrossRef - Parkinson's disease in a worker exposed to insecticides at a greenhouse
Yangwoo Kim, Inah Kim, Jung-Min Sung, Jaechul Song Annals of Occupational and Environmental Medicine.2021;[Epub] CrossRef - Occupational Bronchiolitis
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Murat KALKAN, Can ERENSON Bilimsel Madencilik Dergisi.2020;[Epub] CrossRef - Fluorine detection in the lung tissue of a worker with interstitial pulmonary fibrosis and long-term occupational exposure to polytetrafluoroethylene and perfluorooctanoic acid
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Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans: data from the fourth Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2009
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Kiook Baek, Namhoon Lee, Insung Chung
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Ann Occup Environ Med 2017;29:31. Published online July 10, 2017
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DOI: https://doi.org/10.1186/s40557-017-0181-0
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Abstract
PDFSupplementary MaterialPubReaderePub
- Background
Arsenic is known as an endocrine disruptor that people are exposed to through various sources such as drinking water and indigestion of marine products. Although some epidemiological and animal studies have reported a correlation between arsenic exposure and diabetes development, there are limited studies regarding the toxic effects of organic arsenic including arsenobetaine on the human body. Here, we analyzed the association between urine arsenobetaine and the homeostasis model assessment of β-cell function (HOMA-β), which is an index for predicting diabetes development and reflecting the function of pancreatic β-cells. MethodsIn the fourth Korea National Health and Nutrition Examination Survey (KNHANES), health and nutrition surveys and screening tests were performed. Of the total survey population, people with confirmed values for urine total arsenic and arsenobetaine were included, and known diabetic patients were excluded. A total 369 participants were finally included in the study. We collected surveys on health, height, body weight, body mass index, blood mercury level, fasting glucose level, and serum insulin level and calculated HOMA index. Owing to sexual discrepancy, we performed sexually stratified analysis. ResultsUrine total arsenic and total arsenic minus arsenobetaine was not associated with HOMA-IR and HOMA-β in univariate analysis or in sexually stratified analysis. However, urine arsenobetaine showed a statistically significant relationship with HOMA-β in univariate analysis, and only male participants showed a significant correlation in sexually stratified analysis. In the analysis adjusted for age, BMI, smoking, alcohol drinking, physical activity and blood mercury, the HOMA-β value in the group below the 25th percentile of arsenobetaine was significantly higher than the group between 50 and 75th percentile, while no difference was shown for HOMA-IR. In sexually stratified analysis, The value of HOMA-β was significantly higher in male participants with below the 25th percentile urine arsenobetaine than the group between 25 and 50th and between 50 and 75th, while no difference was shown for HOMA-IR. However, female participants did not demonstrate a relationship between HOMA–IR, HOMA-β and urine arsenobetaine. ConclusionThis study revealed the association between urine arsenobetaine and pancreatic β-cell function assessed by HOMA-β in the normal population (without diabetes), especially in males, despite adjusting for factors affecting pancreatic β-cell function and diabetes. Electronic supplementary materialThe online version of this article (doi:10.1186/s40557-017-0181-0) contains supplementary material, which is available to authorized users.
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Qiang Zhang, Xumei Zhang, Shuying Li, Huihuan Liu, Liangpo Liu, Qingyu Huang, Yaxing Hou, Xiaoshan Liang, Bo Cui, Ming Zhang, Liting Xia, Liwen Zhang, Chen Li, Jing Li, Guifan Sun, Naijun Tang Environment International.2021; 156: 106741. CrossRef - Insulin resistance and pancreatic β cell dysfunction are associated with thyroid hormone functions: A cross-sectional hospital-based study in Turkey
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Tania Ruíz-Vera, Ángeles C. Ochoa-Martínez, Sergio Zarazúa, Leticia Carrizales-Yáñez, Iván N. Pérez-Maldonado Environmental Toxicology and Pharmacology.2019; 67: 79. CrossRef - The role of arsenic in obesity and diabetes
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Shadassa Ourshalimian, Abu Mohd Naser, Mahbubur Rahman, Solaiman Doza, Jennifer Stowell, K.M. Venkat Narayan, Mohammad Shamsudduha, Matthew O. Gribble Environmental Research.2019; 172: 249. CrossRef
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