Annals of Occupational and Environmental Medicine

Na-Young Ha

2 Articles

Relationship between triclosan exposure and thyroid hormones: the Second Korean National Environmental Health Survey (2012–2014): Na-Young Ha, Dae Hwan Kim, Ji Young Ryu; Ann Occup Environ Med 2019;31:e22. Published online September 5, 2019; DOI: https://doi.org/10.35371/aoem.2019.31.e22

Background

5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan) is used as an antiseptic and is a potential endocrine-disrupting chemical that can affect thyroid hormone levels. This study evaluated the relationship between triclosan exposure and thyroid hormones.

Methods

Data from the second Korean National Environmental Health Survey (2012–2014) were analyzed. Triclosan exposure was evaluated using urinary triclosan concentrations and classified into 2 groups: ‘below detection (< limit of detection [LOD])’ vs. ‘detected (≥ LOD).’ Multiple linear regression analysis was conducted to determine the relationship between triclosan exposure and the serum thyroid hormone concentrations, adjusting for age, body mass index, urinary creatinine, and smoking status.

Results

When grouped by sex, triclosan exposure was positively associated with the serum thyroid-stimulating hormone (TSH) concentrations in females with marginal significance (β = 0.066, p = 0.058). However, no significant association was identified between triclosan exposure and serum total triiodothyronine and thyroxine in both males and females, and TSH in males.

Conclusions

This study is the first human study to evaluate the relationship between triclosan exposure and serum thyroid hormone concentrations in the Korean population. There was suggestive positive association between triclosan exposure and the serum TSH in females. Further studies need to evaluate the relationship between long-term exposure to low-dose triclosan and thyroid hormones.

Citations

Citations to this article as recorded by

Relationship between endocrine disrupting chemicals (phthalate metabolites, triclosan and bisphenols) and vitamin D in female subjects: An exploratory pilot study
Edwina Brennan, Alexandra E. Butler, Manjula Nandakumar, Kristie Thompson, Thozhukat Sathyapalan, Stephen L. Atkin
Chemosphere.2024; 349: 140894. CrossRef
Conceptualizing the Role of the Microbiome as a Mediator and Modifier in Environmental Health Studies: A Scoping Review of Studies of Triclosan and the Microbiome
Hannah E. Laue, Aislinn J. Gilmour, Valerie M. Tirado, Megan E. Romano
Current Environmental Health Reports.2024; 11(1): 30. CrossRef
Critical review on the environmental behaviors and toxicity of triclosan and its removal technologies
Yanhong Jiang, Liangying Liu, Biao Jin, Yi Liu, Xiaoliang Liang
Science of The Total Environment.2024; 932: 173013. CrossRef
Triclosan and its alternatives, especially chlorhexidine, modulate macrophage immune response with distinct modes of action
Stefanie Raps, Laura Bahr, Isabel Karkossa, Manuela Rossol, Martin von Bergen, Kristin Schubert
Science of The Total Environment.2024; 914: 169650. CrossRef
“The issues still persist”: a roundtable discussion of perpetual crisis, the massification of grief and joyful black futures
Lwanda Maqwelane, Abongile Nkamisa, Candice Sehoma, Kharnita Mohamed, Gcobani Qambela
Anthropology Southern Africa.2024; 47(1): 85. CrossRef
Associations of Maternal Urinary Concentrations of Phenols, Individually and as a Mixture, with Serum Biomarkers of Thyroid Function and Autoimmunity: Results from the EARTH Study
Glen McGee, Maximilien Génard-Walton, Paige L. Williams, T. I. M. Korevaar, Jorge E. Chavarro, John D. Meeker, Joseph M. Braun, Maarten A. Broeren, Jennifer B. Ford, Antonia M. Calafat, Irene Souter, Russ Hauser, Lidia Mínguez-Alarcón
Toxics.2023; 11(6): 521. CrossRef
Sustainable Conversion of Biowaste to Energy to Tackle the Emerging Pollutants: A Review
Yue Li, Karthikeyan Meenatchisundaram, Karthik Rajendran, Nisarg Gohil, Vinay Kumar, Vijai Singh, Manoj Kumar Solanki, Sharareh Harirchi, Zengqiang Zhang, Raveendran Sindhu, Mohammad J. Taherzadeh, Mukesh Kumar Awasthi
Current Pollution Reports.2023; 9(4): 660. CrossRef
The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review
Mai Homburg, Åse Krogh Rasmussen, Louise Ramhøj, Ulla Feldt-Rasmussen
Frontiers in Endocrinology.2022;[Epub] CrossRef
Obesogens in Foods
Iva Kladnicka, Monika Bludovska, Iveta Plavinova, Ludek Muller, Dana Mullerova
Biomolecules.2022; 12(5): 680. CrossRef
Effectiveness of hand sanitizers in the prevention of COVID-19 and related public health concerns: A review
Jerikias Marumure, Zakio Makuvara, Richwell Alufasi, Lazarus Chapungu, Claudious Gufe
Cogent Public Health.2022;[Epub] CrossRef
Triclosan and Its Consequences on the Reproductive, Cardiovascular and Thyroid Levels
Ana C. Marques, Melissa Mariana, Elisa Cairrao
International Journal of Molecular Sciences.2022; 23(19): 11427. CrossRef
Effect of Maternal Triclosan Exposure on Neonatal Thyroid‐Stimulating Hormone Levels: A Cross‐Sectional Study
Elham Attarian, Karim Ebrahimpour, Mohammadreza Maracy, Seyede Shahrbanoo Daniali, Bahareh Shoshtari-Yeganeh, Malihe Moazeni, Afshin Ebrahimi, Roya Kelishadi, Gabriella Galluccio
Journal of Environmental and Public Health.2022;[Epub] CrossRef
Evaluation of triclosan exposures on secretion of pro-inflammatory cytokines from human immune cells
Wendy J. Wilburn, Sara Jamal, Farah Ismail, Dylan Brooks, Margaret Whalen
Environmental Toxicology and Pharmacology.2021; 83: 103599. CrossRef
Comprehensive insight into triclosan—from widespread occurrence to health outcomes
Maja Milanović, Larisa Đurić, Nataša Milošević, Nataša Milić
Environmental Science and Pollution Research.2021; 30(10): 25119. CrossRef

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Relationship between residence characteristics and polycyclic aromatic hydrocarbon exposure in housewives: second Korean National Environmental Health Survey (2012–2014): Hyung-Gue Park, Na-Young Ha, Dae Hwan Kim, Jeong-Ho Kim, Chae-Kwan Lee, Kunhyung Kim, Ji Young Ryu; Ann Occup Environ Med 2018;30:23. Published online April 18, 2018; DOI: https://doi.org/10.1186/s40557-018-0236-x

Abstract PDF PubReader ePub

Background

Polycyclic aromatic hydrocarbons (PAHs) produced by incomplete combustion have negative effects on human health due to their carcinogenicity and teratogenicity. Indoor sources of PAHs include tobacco smoke, heating sources, and cooking. This study evaluated the relationship between human PAH exposure and residence characteristics.

Method

This study was based on the second Korean National Environmental Health Survey (2012–2014). Non-smoking housewives were included in the analyses (n = 1269). The concentrations of urinary PAH metabolites (2-naphthol, 2-hydroxyfluorene, 1-hydroxyphenanthrene, and 1-hydroxypyrene) were adjusted by urine creatinine level. The geometric mean concentrations of urinary PAH metabolites by residential factors were examined. Logistic regression models were used to evaluate associations between residential variables and PAH exposures.

Results

The adjusted geometric mean concentrations of urinary 2-hydroxyfluorene and 1-hydroxyphenanthrene were significantly higher in the group residing within 100 m of a major road (p < 0.05) than in those residing > 100 m from a major road. In logistic regression analyses, the odds ratio (OR) for exceeding the third quartile of urinary 1-hydroxypyrene concentration was significantly higher in the group using coal or wood fuel for residential heating than in the group using gas (OR = 2.745, 95% confidence interval [CI] = 1.295–5.819). The detached house group had a significantly higher OR for 1-hydroxyphenanthrene compared with the apartment group (OR = 1.515, 95% CI = 1.023–2.243).

Conclusion

Our study shows the evidence of associations between some urinary PAH metabolite levels (1-hydroxyphenanthrene and 1-hydroxypyrene) and residence characteristics. Additional studies are needed to clarify these associations.

Citations

Citations to this article as recorded by

Association of mixed polycyclic aromatic hydrocarbons exposure with oxidative stress in Korean adults
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Scientific Reports.2024;[Epub] CrossRef
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Environmental Research.2023; 238: 117001. CrossRef
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Yifeng Dai, Xijin Xu, Xia Huo, Marijke M. Faas
Ecotoxicology and Environmental Safety.2023; 262: 115314. CrossRef
Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and risk of papillary thyroid carcinoma and nodular goiter: A case-control study in non-occupational populations
Boying Liu, Yanyan Chen, Siyao Li, Yuanyuan Xu, Yi Wang
Environmental Pollution.2021; 269: 116158. CrossRef
Polycyclic aromatic hydrocarbon: environmental sources, associations with altered lung function and potential mechanisms
Li-Min Cao, Ge Mu, Wei-Hong Chen
Chinese Medical Journal.2020; 133(13): 1603. CrossRef
Distribution, sources and health risk of PAHs in urban air-conditioning dust from Hefei, East China
Mengchen Shen, Guijian Liu, Hao Yin, Li Zhou
Ecotoxicology and Environmental Safety.2020; 194: 110442. CrossRef
Association between urinary polycyclic aromatic hydrocarbons and hypertension in the Korean population: data from the Second Korean National Environmental Health Survey (2012–2014)
Tae-Woo Lee, Dae Hwan Kim, Ji Young Ryu
Scientific Reports.2020;[Epub] CrossRef
Comparison of Polycyclic Aromatic Hydrocarbons Exposure Across Occupations Using Urinary Metabolite 1-Hydroxypyrene
Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Donguk Park
Annals of Work Exposures and Health.2020; 64(4): 445. CrossRef

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