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The variation of thiodiglycolic acid concentration in urine with vinyl chloride exposure levels in rats
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Seung Jun Wang, Bong Suk Cha, Jae Hoon Roh, Dong Chun Shin, Myung Su Kim, Keun Jae Jeon
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Korean Journal of Occupational and Environmental Medicine 1999;11(4):431-438. Published online December 31, 1999
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DOI: https://doi.org/10.35371/kjoem.1999.11.4.431
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 Abstract
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- OBJECTIVES
It is the objective of this research to identify the variation of thiodiglycolic acid (TdGA) in urine with vinyl chloride monomer (VCM) exposure levels through methylation.
METHODS
After rats were exposed to vinyl chloride monomer of 4 levels, 0 mg/m3, 50 mg /m3, 150 mg/m3, 500 mg/m3, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 24 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done.
RESULTS
In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary .TdGA concentration in urine according to exposure level of VCM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified.
CONCLUSION
TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.
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KSOEM
