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Neuroendocrine Effects in Occupational Solvents Exposure
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Chae Un Lee, Jong Tae Lee, Ui Wha Chung, Hae Suk Sohn, Deog Hwan Moon, Jin Ho Chun, Jung Hak Kang, Chang Hee Lee, Hwi Dong Kim, Jong Ham Kim, Kui Oak Jung
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Korean Journal of Occupational and Environmental Medicine 1995;7(2):362-374. Published online October 31, 1995
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DOI: https://doi.org/10.35371/kjoem.1995.7.2.362
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 Abstract
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- Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic solvents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls (33men, 85women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone (FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone (GH), and thyroid-stimulating hormone (TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones (FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.
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Citations
Citations to this article as recorded by  - Risk Assessment for Non-Cancer Effects of Volatile Organic Compounds in Children's Products
Jungkon Kim, Jung-Kwan Seo, Taksoo Kim, Gun-Ho Park
Korean Journal of Environmental Health Sciences.2014; 40(3): 178. CrossRef
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