Annals of Occupational and Environmental Medicine

Keun Ho Jang

5 Articles

Two Cases of Methemoglobinemia Induced by the Exposure to Nitrobenzene and Aniline: Chang Hwan Lee, Soo Hyeon Kim, Do Hyung Kwon, Keun Ho Jang, Yong Hoon Chung, Jai Dong Moon; Ann Occup Environ Med 2013;25:31-31. Published online November 1, 2013; DOI: https://doi.org/10.1186/2052-4374-25-31

Objective

To report two cases of methemoglobinemia induced by inhaled nitrobenzene and dermally absorbed aniline.

Methods

We have evaluated a 37-year-old male worker exposed to nitrobenzene by inhalation while conducting maintenance job of mononitrobenzene pump and a 25-year-old male worker exposed dermally to aniline while unloading.

Results

The first case is a 37-year-old male exposed to nitrobenzene. His blood methemoglobin concentration level was initially 19.8%, and chest X-ray was normal. After oxygen therapy, the blood methemoglobin concentration level decreased to 2.1%, and the symptoms were alleviated. The second case is a 25-year-old male exposed dermally to aniline. His chest X-ray was normal, but blood methemoglobin concentration level reached maximally 46.8%. He was treated with methylene blue due to relatively high blood methemoglobin level. Gradually after the treatment, his methemoglobin concentration level was normalized to 0.8% and simultaneously symptoms were resolved.

Conclusions

After the thorough exposure investigations and medical evaluations, we have concluded that these cases were methemoglobinemia induced by occupational exposure to nitrobenzene and aniline. We suggest that businesses which handle methemoglobinemia-causing substances control the engineering process strictly, implement periodic screening, and establish emergency patient management system.

Citations

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Investigating structural dynamics and sensing capabilities: Spectroscopic and DFT analysis of novel AIEE active deferasirox based organic sensor
Sania, Mohammed A. Assiri, Sanwa Rafique, Hasher Irshad, Zulfiqar Ali Khan, Farhan A. Khan, Sohail Anjum Shahzad
Journal of Molecular Structure.2024; 1307: 137963. CrossRef
Methaemoglobinaemia: a potential confounder in COVID-19 respiratory failure
Yang Lin Ting, Jonathan Zhao Min Lim, Pei Ming Yeo, Wen Yuan Sim
Singapore Medical Journal.2024; 65(Suppl 1): S24. CrossRef
Methaemoglobinaemia due to nitrobenzene poisoning
K. Chandrasekhar, P. Chandana Sree, Bhattaram Siddhartha Kumar, Mounika Nemilete
Journal of Clinical and Scientific Research.2023; 12(Suppl 2): S123. CrossRef
A Case of Methemoglobinemia Caused by Toluidine Revelation with Dyspnea and Cyanosis
Ayaka SANADA, Shun-ichi NIHEI, Shigeto ISHIKAWA, Misako YAMASHITA, Chikako MONOE, Hiroki OOTSUBO, Masayuki KAMOCHI, Toshihiko MAYUMI
Journal of UOEH.2022; 44(2): 185. CrossRef
Herbicide poisoning assocaited methhemoglobinemia as a cause of hypoxia — approach & emergency management — A case report
Sudhir Deshpande, Sagar Gupta, Yashawini Tupkary, Shivprasad Sankpal
Indian Journal of Forensic and Community Medicine.2022; 9(1): 36. CrossRef
Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative
Dimosthenis A. Sarigiannis, Spyros Karakitsios, Elena Dominguez-Romero, Krystalia Papadaki, Celine Brochot, Vikas Kumar, Marta Schuhmacher, Moustapha Sy, Hans Mielke, Mathias Greiner, Marcel Mengelers, Martin Scheringer
Environmental Research.2019; 172: 216. CrossRef
Methemoglobinemia Following Monolinuron Ingestion
Guillaume Mortamet, Mehdi Oualha, Sylvain Renolleau, Christian Moesch, Jean-Marc Treluyer
Pediatric Emergency Care.2018; 34(3): e55. CrossRef
Methemoglobinemia resulting from exposure in a confined space: Exothermic self-polymerization of 4,4′-methylene diphenyl diisocyanate (MDI) material
Philip A. Smith, Jeffrey Lodwick, Joe Dartt, Jenny R. Amani, Kathleen M. Fagan
Journal of Occupational and Environmental Hygiene.2017; 14(1): D13. CrossRef
Unintentional mass sodium nitrite poisoning with a fatality
Changhwan Lee, Eun Jung Jang, Hyesun Yum, Young Shik Choi, Jeongik Hong
Clinical Toxicology.2017; 55(7): 678. CrossRef
Crystal structure of bis(prop-2-yn-1-yl) 5-nitroisophthalate
K. S. Ezhilarasi, Sivasamy Selvarani, Perumal Rajakumar, B. K. Revathi, G. Usha
Acta Crystallographica Section E Crystallographic Communications.2015; 71(6): o435. CrossRef
The painted shoes
Natália Noronha, André Rosa Alexandre, Joana Cavaca Santos, Fernanda Rodrigues
BMJ Case Reports.2015; : bcr2015210619. CrossRef

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A Suspicious Case of Chloroform Induced Acute Toxic Hepatitis in Laboratory Worker: Dae Gwang Lee, Chang Hwan Lee, Keun Ho Jang, Hong Jae Chae, Jai Dong Moon; Korean Journal of Occupational and Environmental Medicine 2012;24(3):304-310. Published online September 30, 2012; DOI: https://doi.org/10.35371/kjoem.2012.24.3.304

Abstract PDF

OBJECTIVES
To report upon a case of toxic hepatitis in a worker exposed to chloroform.
METHODS
A 28-year-old female who had worked as chemical analysis engineer in a laboratory using chloroform was hospitalized due to nausea, vomiting and generalized weakness. The authors evaluated her using blood tests, abdominal CT scan and her occupational history.
RESULTS
The blood tests revealed acute toxic hepatitis. Other causes of hepatitis such as viral, drug induced or alcoholic hepatitis could be excluded. But autoimmune hepatitis couldn't be totally ruled out(ANA (++), IgG(serum) 1780 mg/dL). After admission, her symptoms improved and her liver enzyme levels(AST and ALT) were markedly reduced. She returned to her workplace after discharge. Afterwards, however, her liver enzyme levels increased again one week after returning to her workplace. Subsequent to a job change, her liver enzyme levels reduced and normalized after eight weeks. The airbone laboratory chloroform ranged from 3.155 to 9.037 ppm.
CONCLUSIONS
The authors presume that this patient's liver injury was related to an interaction of chloroform toxicity and a predisposition to autoimmune hepatitis. The rapid improvement of the clinical symptoms and the progressive normalization of the liver function tests once the chloroform exposure eliminated supports the diagnosis.

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Recent advances in non-fullerene organic photovoltaics enabled by green solvent processing
Shilin Li, Hong Zhang, Shengli Yue, Xi Yu, Huiqiong Zhou
Nanotechnology.2022; 33(7): 072002. CrossRef
A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef
Aliphatic Halogenated Hydrocarbons: Report and Analysis of Liver Injury in 60 Patients
Rolf Teschke
Journal of Clinical and Translational Hepatology.2018;[Epub] CrossRef
A Study on Fabrication of 3D Dual Pore Scaffold by Fused Deposition Modeling and Salt-Leaching Method
Hae-Ri Shim, Jong Young Kim
Transactions of the Korean Society of Mechanical Engineers A.2015; 39(12): 1229. CrossRef
Acute liver injury in two workers exposed to chloroform in cleanrooms: a case report
Young Joong Kang, Jungho Ahn, Yang-In Hwang
Annals of Occupational and Environmental Medicine.2014;[Epub] CrossRef

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Comparison of Cardiovascular Disease Status Between Large Scale Industry Office and Self Employed Male Workers: Keun Ho Jang, Won Ju Park, Myeong Bo Kim, Dae Kwang Lee, Hong Jae Chae, Jai Dong Moon; Korean Journal of Occupational and Environmental Medicine 2011;23(2):130-138. Published online June 30, 2011; DOI: https://doi.org/10.35371/kjoem.2011.23.2.130

Abstract PDF

OBJECTIVES
The aim of this study is to compare the cardiovascular disease status between large scale industry office and self employed male workers who have gaps in their intensive health management.
METHODS
The cross sectional study was carried out with subjects composed of 244 shipyard office male workers and 381 self employed male workers, aged 30 to 55 years. They were given a health exam in a general hospital from January 2007 to June 2009. Information was based on data from self-administered questionnaires, physical examination and laboratory results on blood samples. The degree of coronary artery calcification and stenosis was evaluated by a 64 channel multi-detector computed tomography angiography.
RESULTS
The prevalence of hypertension(p<0.01) and diabetes mellitus(p=0.02) and waist circumference(p<0.01) was significantly lower in the shipyard office workers than in self employed workers. Proper drinking(p<0.01) was more commmon in shipyard office workers. The rates of coronary artery calcification and stenosis were estimated to be 18.4% and 11.5% respectively for shipyard office workers and were significantly lower than the 26.5% and 21.5% for self employed workers. After adjustment for age, the probability of coronary artery stenosis in shipyard office workers was lower than in self employed workers (OR=0.56, 95% CI=0.35~0.90).
CONCLUSIONS
The study results verified the benefits of a health promotion and intervention program and the healthy worker effect for cardiovascular diseases. More specifically, it verified the benefits regarding coronary artery stenosis in large scale industry office workers. This result should encourage the establishment of health promotion programs and the study of occupational epidemiology.

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The effect of employment transitions on physical health among the elderly in South Korea: A longitudinal analysis of the Korean Retirement and Income Study
Juyeon Lee, Myoung-Hee Kim
Social Science & Medicine.2017; 181: 122. CrossRef
Association of Work-related Characteristics and Hypertension among White Collar Workers
Chae-Bong Kim, KyooSang Kim
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(3): 418. CrossRef
Comparison of oral health status by metabolic syndrome risk factors in workers
In-Young Ku, Seon-Jeong Moon, Myeong-Seon Lee, Kyung-Hwan Ka
Journal of Korean society of Dental Hygiene.2013; 13(4): 581. CrossRef

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Comparison of Cardiovascular Disease Risk Assessment Tools by Using Coronary CT Angiography: Myeong Bo Kim, Won Ju Park, Keun Ho Jang, Dae Kwang Lee, Hong Jae Chae, Jai Dong Moon; Korean Journal of Occupational and Environmental Medicine 2010;22(2):102-113. Published online June 30, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.2.102

Abstract PDF

OBJECTIVE: The prevalence and mortality rate of cardiovascular disease (CVD) have increased among Koreans over the past 20 years. To manage and control this disease, various CVD risk assessment tools such as KOSHA (Korean Occupational Safety and Health Agent) CVD risk assessment, the presence of metabolic syndrome and the Framingham risk score (FRS) have been developed and applied to employees at the workplace. This study was designed to compare the validity of the CVD risk assessment tools mentioned above with the findings of coronary CT angiography (CCTA).
METHODS
The subjects of this study who were 490 male-workers aged between 31 and 70, and these subjects were selected among those who had visited a University Hospital for a general health examination and who underwent CCTA from January 2007 to June 2009. Chi-square tests and logistic regression analysis were used to compare and analyze the associations between the CVD risk assessment tools and the coronary artery changes such as calcification and stenosis.
RESULTS
Metabolic syndrome (OR=1.90, 95% CI 1.23-2.95) and the Framingham risk score (OR=2.71, 95% CI 1.83-4.01) were the significant and meaningful predictors of coronary artery calcification. On the analysis of the association with coronary artery stenosis, only the Framingham risk score (OR=2.21, 95% CI 1.46-3.36) turned out to be a significant and meaningful predictor.
CONCLUSION
The results suggest that the Framingham risk score is a relatively valid CVD risk assessment tool. Henceforth, to effectively manage cardiovascular diseases in the workplace, advanced tools and indicators for management should be considered and provided based on meaningful study results.

Citations

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Sex differences in the relationship between depression and cardiovascular disease risk: a nationwide study in Korea
Seol-bin Kim, Ihn Sook Jeong
Osong Public Health and Research Perspectives.2021; 12(2): 105. CrossRef
Factors related to Coronary Artery Disease in Korean Adults: Based on the Korean National Health and Nutrition Examination Survey 2013~2015
Sook Young Kim
The Korean Journal of Rehabilitation Nursing.2018; 21(1): 33. CrossRef
The Assessment of Framingham Risk Score and 10 Year CHD Risk according to Application of LDL Cholesterol or Total Cholesterol
Se Young Kwon, Young Ak Na
Korean Journal of Clinical Laboratory Science.2016; 48(2): 54. CrossRef
The Relationship between Coronary Risk Factors and Coronary Calcium Score Detected by Computed Tomography Coronary Angiography in Korean Middle Aged Men
Seung-Hyun Park, Young-Wook Kim, Chang-Ho Chae, Ja-Hyun Kim, Yune-Sik Kang, Yong Whi Park, Baek Geun Jeong
Journal of agricultural medicine and community health.2014; 39(1): 25. CrossRef
Relationship between Conventional Cardiovascular Disease Risk Assessment and Coronary Artery Calcification in Group Exposed to Inorganic Dusts
Won-Jeong Lee, So Young Park
Journal of the Korean Society of Radiology.2013; 68(5): 397. CrossRef
Relation of Pulmonary Function Impairment and Coronary Artery Calcification by Multi-detector Computed Tomography in Group Exposed to Inorganic Dusts
Won-Jeong Lee, Jae Hoon Shin, So Young Park
Tuberculosis and Respiratory Diseases.2013; 74(2): 56. CrossRef
Evaluate the diagnostic accuracy in the assessment of coronary artery stenoses using MDCT
Won-Seok Yang, Sung-Gyu Sin, Jae-Hong Park
Journal of the Korean Society of Radiology.2012; 6(4): 275. CrossRef

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The Relationship of Serum CEA Levels and Type of Work in Shipyard Workers: Won Ju Park, Myoung Bo Kim, Yang Hyun Kim, Ryoung Jin Park, Keun Ho Jang, Hong Jae Chae, Jai Dong Moon; Korean Journal of Occupational and Environmental Medicine 2009;21(4):293-300. Published online December 31, 2009; DOI: https://doi.org/10.35371/kjoem.2009.21.4.293

Abstract PDF

OBJECTIVES
Benign conditions have been known to cause an increase in the levels of serum carcinoembryonic antigen, a level change that is often associated with an increase in the occurrence of malignancy. The purpose of this study was to elucidate the relationship between serum CEA levels and type of work in shipyard workers.
METHODS
From July-August 2007, 637 study subjects were enrolled into the study with the following characteristics: age 37~58 years, healthy shipyard workers, and who undergone an examination in a general hospital. Data on general characteristics was gathered from self-administered questionnaires. Information on job factors was collected from company personnel data. Serum CEA levels were measured after 10 hours'fasting.
RESULTS
The level of mean serum CEA was 1.83+/-1.20 ng/mL. On univariate analysis, the mean CEA level was significantly higher in older age groups (P<0.05), current smokers, lower education, and in production workers (P<0.01). After adjusting for age, BMI, cigarette smoking, job pattern, and educational level, the serum CEA level was higher in production workers than in office workers(P<0.01). This is particularly true in the shipyard painters, who had the highest level of CEA across job groups.
CONCLUSIONS
The goal of this was to determine if there were differences in serum CEA levels according to occupational role in shipyard workers. Production shipyard workers had relatively higher level of serum CEA than office workers, most likely due to occupational exposure. This serum CEA level is influenced by occupation role. Serum CEA level could be a parameter for evaluating pollutant effects.

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The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef

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