Annals of Occupational and Environmental Medicine

Jae Young Yu

2 Articles

Toxic Hepatitis Induced by Occupational Dimethylacetamide Exposure: Tae Sung Choi, Kuck Hyeun Woo, Jin Seok Kim, Wan Seup Park, Jung Ho Ham, Sang Je Jung, Jae Young Yu; Korean Journal of Occupational and Environmental Medicine 2001;13(2):164-170. Published online June 30, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.2.164

Dimethylacetamide is widely used in the production of plastics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid of dimethylacetamide(DMAC) can cause liver damage. Toxic hepatitis possibly attributable to DMAC exposure occurred in seven works among 178 employees who had worked on a new spandex-fiber production line. A large amount of DMAC is used as a spinning solvent for synthetic fibers in the factory. The patients were aged 23-47 years old and composed of five males and two females. They were involved in the process of polymerization(1 patient), spinning(1), take-up(4) and packaging(1). The mean duration of exposure was 10 weeks. They experienced fatigue, dizziness and jaundice. The patients showed elavated total bilirubin, alanine aminotransferase(ALT), and aspartate aminotransferase(AST) levels. The serologic test for viral hepatitis A, B and C were negative, as were the abdominal ultrasonographic scans. Based on the presumptive diagnosis of DMAC-induced toxic hepatitis, they were removed from the workplaces. One or two months after removal from the work, the transaminase levels returned to normal. The patients had no history of significant alcohol use, blood transfusion, recent medication, and drug abuse. As a result, authors could not find any attributable cause of toxic hepatitis but the toxicity by DMAC exposure.

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Intravenous Busulfan, Dimethylacetamide and neurotoxicity after high-dose pretransplant conditioning chemotherapy
J. Ramdial, K. H. Chan, G. Sanchez Petitto, B. Valdez, B. S. Andersson, Y. Nieto
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A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef
A green approach to porous and dense antifouling membranes through solvent-free bulk polymerization
Runnan Zhang, Jinming Peng, Yanlei Su, Xiaochen Fan, Zhongyi Jiang, Xueting Zhao, Jiazhen Liu, Yafei Li, Jiaojiao Zhao
Chemical Engineering Science.2015; 135: 501. CrossRef
Grand Rounds: An Outbreak of Toxic Hepatitis among Industrial Waste Disposal Workers
Hae-Kwan Cheong, Eun A Kim, Jung-Keun Choi, Sung-Bong Choi, Jeong-Ill Suh, Dae Seob Choi, Jung Ran Kim
Environmental Health Perspectives.2007; 115(1): 107. CrossRef
Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers
C-Y Lee, S-J Jung, S-A Kim, K-S Park, B-G Ha
Occupational and Environmental Medicine.2006; 63(10): 688. CrossRef

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Related factors of high frequency hearing loss in the noise-exposed male workers: Sang Je Jung, Kuck Hyeun Woo, Wan Deup Park, Jae Young Yu, Tae Sung Choi, Sang Woo Kim, Jin Seok Kim; Korean Journal of Occupational and Environmental Medicine 2000;12(2):187-197. Published online June 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.2.187

Abstract PDF

OBJECTIVES
The purpose of the study was to assess the risk factors assumed to be related to the high frequency hearing loss in the noise-exposed male workers.
METHODS
712 occupationally noise-exposed male workers were included in this cross sectional study. The subjects filled out a questionnaire on the history of noise exposure, hearing protection, otologic diseases, tobacco smoking, and were tested on height, weight, hematocrit, serum total cholesterol level, fasting plasma glucose level and arterial blood pressure level. Pure tone audiometry and otoscopy were conducted and the subjects were allocated into two groups according to whether they had 4000 Hi hearing loss or not.
RESULTS
The multiple logistic regression analysis showed that military noise exposure, poor wearing status of the hearing protection devices, increased age, long noise exposure duration, mean arterial pressure less than 80mmHg, high fasting plasma sugar are the factors significantly related to high frequency hearing loss (P<0.05). On the contrary, there was no significant relationship between noise intensity, body mass index, serum total cholesterol level, smoking and high frequency hearing loss. Low hematocrit was shown to be a significant factor with a p-value less than 0.1.
CONCLUSIONS
High frequency hearing loss in the noise-exposed male workers is related to military noise exposure, use of hearing protection devices, age, noise exposure length, fasting glucose level and mean arterial pressure, in this order. Appropriate use of the hearing protection devices has a great impact on the prevention of the noise-induced hearing loss.

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The effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
Dae Yun Kim, A Ram Kim, Joo Hyun Sung, Choong Ryeol Lee, Jiho Lee
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef

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