-
Factors Associated with Psychoneurobehavjral Outcomes in Workers Exposed to Manganese
-
Kyoo Sang Kim, Yangho Kim, Youngwoo Jin, Euna Kim, Jeong Sun Yang, Kwi Ryun Kwon, Jae Woo Kim, Jaehoon Roh, Young Hahn Moon
-
Korean Journal of Occupational and Environmental Medicine 1999;11(2):213-228. Published online June 30, 1999
-
DOI: https://doi.org/10.35371/kjoem.1999.11.2.213
-
-
 Abstract
 PDF
- The risk posed to human health by environmental manganese (Mn) exposure is unknown. The purpose of this study is to establish if subclinical effects related to Mn exposure and examine the factors influencing psychoneurobehaviral outcomes of Mn exposed workers. This study involved 121 male workers of welding, alloy furnace, and manufacturing of welding stick. Study investigations include: a questionnaire covering demographic characteristics, job and exposure history and medical symptoms and conditions, monitoring workplace air for personal exposure to respirable and inhalable manganese, analysis of blood and urine samples. psychoneurobehaviral test(neurobehaviral core test battery (NCTB), signal change on magnetic resonance imaging (MRJ) scans, minimental state and neurological examination). The main results of this study were as follows: 1. Preliminary results showed that, with increasing manganese exposure, neurobehaviral performance was poorer and signal change on MRI scans increased. 2. The results of examination revealed significant relations on psychoneurobehaviral out-comes (neurobehaviral performance, signal change on MRI scans, and neurological features). 3. In multiple regression, age and educational status as demographic variables and exposure level were significantly related to 4neurobehaviral test. Also exposure level and serum Mn concentrations were positively relatel to signal change on MRI scans and neurological features affected by Mn on the brain (signal change). 4. Psychoneurobehaviral outcomes from Mn exposure were related to neurobehaviral performance, signal change on MRJ scans, neurological features and profile of mood states (POMS), and influnced positively with age, alcohol and smoking history, and duration of Mn exposure, negatively with educational status. Serum Mn concentrations in combination with brain MRI scans, and perhaps a battery of neurobehaviral tests, appear to be the best way to monitor excessive exposure to Mn. These results are consistent with our knowledge on Mn action on the brain and are similar to the type of neurobehaviral dysfunction. They suggest that there may be age, educational status, and life style (alcohol and drinking history) differences with chronic environmental exposure. These findings suggest further evaluation, particularly on relationships between Mn exposure, aging, and susceptibility factors.
-
Citations
Citations to this article as recorded by  - A Study on the Total, Particle Size-Selective Mass Concentration of Airborne Manganese, and Blood Manganese Concentration of Welders in a Shipbuilding Yard
Jong Su Park, Pan Gyi Kim, Jee Yeon Jeong
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(4): 472. CrossRef - Associations between Airborne Manganese and Blood Manganese in the Korean General Population according to KNHANES 2008-2009
Kyung Sick Jung, Jong Dae Lee, Yong Bae Kim
Journal of Environmental Science International.2013; 22(12): 1589. CrossRef - Neurobehavioral Deficits and Parkinsonism in Occupations with Manganese Exposure: A Review of Methodological Issues in the Epidemiological Literature
Robert M. Park
Safety and Health at Work.2013; 4(3): 123. CrossRef - Olfactory functions at the intersection between environmental exposure to manganese and Parkinsonism
Silvia Zoni, Giulia Bonetti, Roberto Lucchini
Journal of Trace Elements in Medicine and Biology.2012; 26(2-3): 179. CrossRef - Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef - Exposure-Response Relationship and Risk Assessment for Cognitive Deficits in Early Welding-Induced Manganism
Robert M. Park, Rosemarie M. Bowler, Harry A. Roels
Journal of Occupational & Environmental Medicine.2009; 51(10): 1125. CrossRef - State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk?
Annette B. Santamaria, Colleen A. Cushing, James M. Antonini, Brent L. Finley, Fionna S. Mowat
Journal of Toxicology and Environmental Health, Part B.2007; 10(6): 417. CrossRef - Issues in neurological risk assessment for occupational exposures: The Bay Bridge welders
Robert M. Park, Rosemarie M. Bowler, Donald E. Eggerth, Emily Diamond, Katie J. Spencer, Donald Smith, Roberto Gwiazda
NeuroToxicology.2006; 27(3): 373. CrossRef - Potential occupational risks for neurodegenerative diseases
Robert M. Park, Paul A. Schulte, Joseph D. Bowman, James T. Walker, Stephen C. Bondy, Michael G. Yost, Jennifer A. Touchstone, Mustafa Dosemeci
American Journal of Industrial Medicine.2005; 48(1): 63. CrossRef
-
34
View
-
0
Download
-
9
Crossref
|
KSOEM
