-
Validation of urinary 1,2-dichloropropane concentration as a biological exposure index for workers exposed to 1,2-dichloropropane
-
Chung-Soo Park, Hyun-Soo Kim, Yeon-Soon Ahn, Jung-Ho Ahn, Kyoung Sook Jeong
-
Ann Occup Environ Med 2020;32:e24. Published online July 7, 2020
-
DOI: https://doi.org/10.35371/aoem.2020.32.e24
-
-
Abstract
PDFPubReaderePub
- Background
The International Agency for Research on Cancer classified 1,2-dichloropropane (1,2-DCP) as a human carcinogen in 2016. It is necessary to establish a health monitoring system for workers exposed to 1,2-DCP. We investigated the correlation between 1,2-DCP concentration in air and urine to determine whether it is appropriate to measure 1,2-DCP in urine as a biological exposure index (BEI). MethodsTwenty-seven workers from 3 manufacturing industries handling 1,2-DCP participated in this study. Airborne 1,2-DCP was collected by personal air. Urine samples were collected at the end of work and analyzed using gas chromatography-mass spectrometry. Correlation analysis and simple regression analysis were performed to investigate the relationship between 1,2-DCP concentration in urine and air. ResultsPearson correlation coefficients between total 1,2-DCP in air and urine (uncorrected, creatinine-corrected) were 0.720 and 0.819, respectively. For urine samples analyzed within 2 weeks, the Spearman's rho of 1,2-DCP concentration in urine (uncorrected and creatinine-corrected) was 0.906 and 0.836, respectively. Simple regression analysis of 1,2-DCP in air and urinary 1,2-DCP concentrations within 2 weeks, which showed the highest correlation, revealed that the coefficient of determination of 1,2-DCP concentration in urine (uncorrected and creatinine-corrected) was 0.801 and 0.784, respectively. ConclusionsAs a BEI for workers exposed to 1,2-DCP, urinary 1,2-DCP without creatinine correction better reflects the exposure levels of 1,2-DCP in air.
-
Citations
Citations to this article as recorded by
- Acute 1,2-Dichloropropane Poisoning due to Ingestion of Rubber Cement
Qiuyu Pang, Lexin Zheng, Ruoyu Huang, Heng Xu, Chong Pan, Zhiyong Wang, Tao Wang American Journal of Forensic Medicine & Pathology.2023;[Epub] CrossRef - Systematic review of the human health hazards of propylene dichloride
Heather N. Lynch, Jordan S. Kozal, Melissa J. Vincent, Rachel D. Freid, Evan M. Beckett, Sarah Brown, Claire Mathis, Rita S. Schoeny, Andrew Maier Regulatory Toxicology and Pharmacology.2023; 144: 105468. CrossRef
-
39
View
-
0
Download
-
2
Web of Science
-
2
Crossref
|