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A Case of Goodpasture's Syndrome in a Foundry Worker
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Min Gi Kim, Dong Hee Koh, Sun Wong Lee, Min Heui Jo, Hee Yong Yoo, Bo Yeon Kim, June Hyuk Lee
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Korean Journal of Occupational and Environmental Medicine 2008;20(1):46-53. Published online March 31, 2008
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DOI: https://doi.org/10.35371/kjoem.2008.20.1.46
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 Abstract
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- BACKGROUND
Smoking, upper respiratory tract infection, genetic factors and hydrocarbons are known as risk factors of Goodpasture's syndrome. We studied a patient with Goodpasture's syndrome who had worked for 27 years in a foundry company. Based on a study on the work-relatedness of the syndrome, we describe and discuss our study results.
CASE
A 46-year-old man, who had worked as a foundry worker for 27 years and had a 12 1/2 packyear history of smoking cigarettes, was admitted into a hospital on 15th February 2006 with coughing, chest pain and dyspnea. On admission, he had hematuria, proteinuria, severe restrictive pulmonary function disorder and rapid elevation of blood urea nitrogen/creatinine. Immunological examination showed ANA (+), ANCA (-) and Anti-GBM Ab (+). Kidney biopsy showed pauci-immune crescentic glomerulonephritis. Mild bleeding was revealed through bronchoscopy and no vasculitis and granuloma were present on at lung biopsy. Finally, we diagnosed the worker's illness as Goodpasture's syndrome and carried out hemodialysis and plasmapheresis. In the workplace survey, the exposure level of respirable crystalline silica exceeded the TLV-TWA (0.0106 mg/m3), which was calibrated for overtime.
CONCLUSION
Based on both the clinical test and industrial hygiene examination, we concluded that the Goodpasture's syndrome in this case was caused by long-term silica exposure.
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Citations
Citations to this article as recorded by  - Cause-Specific Mortality Due to Malignant and Non-Malignant Disease in Korean Foundry Workers
Jin-Ha Yoon, Yeon-Soon Ahn, Suminori Akiba
PLoS ONE.2014; 9(2): e88264. CrossRef - Goodpasture’s Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association
Amanjit Bal, Ashim Das, Dheeraj Gupta, Mandeep Garg
Case Reports in Pulmonology.2014; 2014: 1. CrossRef - Goodpasture's Syndrome and Silica: A Case Report and Literature Review
James Dahlgren, Marla Wardenburg, Trevor Peckham
Case Reports in Medicine.2010; 2010: 1. CrossRef
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