Annals of Occupational and Environmental Medicine

Eun Yong Kang

2 Articles

The Influence of Smoking, Alcohol Ingestion, and Physical Activity on Copper, Zinc and Ceruloplasmin in Blood of Male Adults: Jin Wan Park, Eun Yong Kang, In Cheol Shin, Byung Sun Choi, Jung Duck Park, Im Won Chang, Yeon Pyo Hong; Korean Journal of Occupational and Environmental Medicine 1999;11(4):569-578. Published online December 31, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.4.569

Objective : To investigate the influence of smoking, alcohol ingestion, and physical activity on copper and zinc in RBC and serum and serum ceruloplasmin, this study was performed in a cross-sectional study in 113 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases.
METHODS
At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of copper, zinc, iron, ceruloplasmin, total cholesterol, and hematocrit. Each man completed a questionnaire that provided information on smoking, amount of alcohol intake, and physical activity. Partial regres sion analysis was performed on confounding variables such as age, body mass index, hematocrit, serum cholesterol, and serum iron.
RESULTS
In general linear models, adjustment for confounding variables did not show statistical differences, and there was only an increasing tendency in serum copper in heavy smoker (P=0.0678). There was no difference between high physical activity with mild smokers and lower physical activfty with, heavy smokers.
CONCLUSIONS
This study suggested that copper, zinc and eeruloplasmin were not good biomarker for early effect by smoking, alcohol intake and physical activity in young adult. However, selection bias should be considered in evaluation of this result, and a large prospective study will be needed in advance on usefulness of copper, zinc and ceruloplasmin as a marker for risk factors and early change of atherosclerosis.

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Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population
Beatrice Bocca, Roberto Madeddu, Yolande Asara, Paola Tolu, Juan A. Marchal, Giovanni Forte
Journal of Trace Elements in Medicine and Biology.2011; 25(1): 19. CrossRef

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Reference Value of Cadmium in Myocardium in Korean: Jung Duck Park, Heon Bang Lim, Byung Sun Choi, Il Hoon Kweon, Sang Yeon Lee, Eun Yong Kang, Yeon Pyo Hong, Im Won Chang; Korean Journal of Occupational and Environmental Medicine 1999;11(1):24-32. Published online March 31, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.1.24

Abstract PDF: Cadmium(Cd) is an ubiquitous, toxic and non-essential metal which is controversial about the association with a cardiovascular disease. In this study, we investigated the reference level of Cd in myocardium in Korean general population. The level of Cd and zinc(Zn) concentration in myocardium of 252 cases of "sudden and unexpected death" autopsies(male 172, female 60) aged 0 to 87 years was analyzed. The concentration of Cd and Zn was determined with atomic absorption spectrophotometer(Perkin-Elmer Model 5100) by flameless and flame method, respectively. The content of Cd and Zn in myocardium showed the log-normal distribution rather than normal distribution. Geometric mean concentration of Cd was 0.19 microgram/g wet weight in myocardium. The level of Cd in myocardium was not significantly different between male(0. 18 microgram/g wet weight) and female(0.22 microgram/g wet weight). Geometric mean concentration of Zn in myocardium was 25.25 microgram/g wet weight. The level of Zn between male(25.13 microgram/g wet weight) and female(25.57 microgram/g wet weight) was not different. The deposit of Cd in myocardium was age-dependent of biphasic pattern, but the Zn level by age was not significantly different. The level of Cd in myocardium was increased to the fifties of age, thereafter a leveling-off was shown. The regression model of Cd deposit in myocardium by age was predicted as the following equation Log Heart-Cd = -1.2726 + 0.0234 Age - 0.0002 Age2. The maximum Cd deposit in myocardium was estimated to be 0.26 microgram/g wet weight at the age of 58.5 in Korean general population. In addition, the total Cd burden in heart by age was predicted as a following equation Total Cd burden in Heart = -10.165 + 2.891 Age - 0.0258 Age2. The maximum heart burden of Cd was estimated to be 70.7 microgram at age of 55.4. The positive correlation between Cd and Zn was observed in myocardium. The linear regression equation was Log Heart-Zn = 1.4195 +/- 0.0262- Log Heart-Cd.

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