Annals of Occupational and Environmental Medicine

Dong Chun Shin

5 Articles

Residential radon and environmental burden of disease among Non-smokers: Juhwan Noh, Jungwoo Sohn, Jaelim Cho, Dae Ryong Kang, Sowon Joo, Changsoo Kim, Dong Chun Shin; Ann Occup Environ Med 2016;28:12. Published online March 15, 2016; DOI: https://doi.org/10.1186/s40557-016-0092-5

Background

Lung cancer was the second highest absolute cancer incidence globally and the first cause of cancer mortality in 2014. Indoor radon is the second leading risk factor of lung cancer after cigarette smoking among ever smokers and the first among non-smokers. Environmental burden of disease (EBD) attributable to residential radon among non-smokers is critical for identifying threats to population health and planning health policy.

Methods

To identify and retrieve literatures describing environmental burden of lung cancer attributable to residential radon, we searched databases including Ovid-MEDLINE, -EMBASE from 1980 to 2016. Search terms included patient keywords using ‘lung’, ‘neoplasm’, exposure keywords using ‘residential’, ‘radon’, and outcomes keywords using ‘years of life lost’, ‘years of life lost due to disability’, ‘burden’. Searching through literatures identified 261 documents; further 9 documents were identified using manual searching. Two researchers independently assessed 271 abstracts eligible for inclusion at the abstract level. Full text reviews were conducted for selected publications after the first assessment. Ten studies were included in the final evaluation.

Review

Global disability‐adjusted life years (DALYs)(95 % uncertainty interval) for lung cancer were increased by 35.9 % from 23,850,000(18,835,000-29,845,000) in 1900 to 32,405,000(24,400,000-38,334,000) in 2000. DALYs attributable to residential radon were 2,114,000(273,000-4,660,000) DALYs in 2010. Lung cancer caused 34,732,900(33,042,600 ~ 36,328,100) DALYs in 2013. DALYs attributable to residential radon were 1,979,000(1,331,000-2,768,000) DALYs for in 2013. The number of attributable lung cancer cases was 70-900 and EBD for radon was 1,000-14,000 DALYs in Netherland. The years of life lost were 0.066 years among never-smokers and 0.198 years among ever-smoker population in Canada.

Conclusion

In summary, estimated global EBD attributable to residential radon was 1,979,000 DALYs for both sexes in 2013. In Netherlands, EBD for radon was 1,000–14,000 DALYs. Smoking population lost three times more years than never-smokers in Canada. There was no study estimating EBD of residential radon among never smokers in Korea and Asian country. In addition, there were a few studies reflecting the age of building, though residential radon exposure level depends on the age of building. Further EBD study reflecting Korean disability weight and the age of building is required to estimate EBD precisely.

Electronic supplementary material

The online version of this article (doi:10.1186/s40557-016-0092-5) contains supplementary material, which is available to authorized users.

Citations

Citations to this article as recorded by

Risk Assessment of Lung Cancer Caused by Indoor Radon Exposure in China during 2006–2016: A Multicity, Longitudinal Analysis
Ziqi Qiang, Yupeng Yao, Zhiling Li, Dapeng Lin, Huan Li, Haidong Kan, Weihai Zhuo, Bo Chen, Shah Fahad
Indoor Air.2023; 2023: 1. CrossRef
Radon Hazard of the Zhurinsky Fault for the Population in the Kuznetsk Coal Basin: Primary Results
Timofey Leshukov, Konstantin Legoshchin, Aleksey Larionov
Sustainability.2023; 15(24): 16774. CrossRef
Screening Criteria Evaluation for Expansion in Pulmonary Neoplasias (SCREEN)
Bright Huo, Daria Manos, Zhaolin Xu, Kara Matheson, Samuel Chun, John Fris, Alison M.R. Wallace, Daniel G. French
Seminars in Thoracic and Cardiovascular Surgery.2023; 35(4): 769. CrossRef
Burden of lung cancer attributable to household air pollution in the Chinese female population: trend analysis from 1990 to 2019 and future predictions
Zhixue Li, Yan Ma, Ying Xu
Cadernos de Saúde Pública.2022;[Epub] CrossRef
Environmental/Occupational Exposure to Radon and Non-Pulmonary Neoplasm Risk: A Review of Epidemiologic Evidence
Paola Mozzoni, Silvana Pinelli, Massimo Corradi, Silvia Ranzieri, Delia Cavallo, Diana Poli
International Journal of Environmental Research and Public Health.2021; 18(19): 10466. CrossRef
The Assessment of Radon Emissions as Results of the Soil Technogenic Disturbance
Timofey Leshukov, Aleksey Larionov, Konstantin Legoshchin, Yuriy Lesin, Svetlana Yakovleva
International Journal of Environmental Research and Public Health.2020; 17(24): 9268. CrossRef
SDHA‐mediated Warburg effect in malignantly transformed human bronchial epithelial cells following long‐term exposure to radon
Xing Liu, Zongpeng Zhou, Zikun Wang, Xiangming Li, Guangyu Lu, Jian Tong
Environmental Toxicology.2020; 35(8): 861. CrossRef
Radon, an invisible killer in Canadian homes: perceptions of Ottawa-Gatineau residents
Selim M. Khan, Daniel Krewski, James Gomes, Raywat Deonandan
Canadian Journal of Public Health.2019; 110(2): 139. CrossRef
Residents’ perceptions of radon health risks: a qualitative study
Selim M. Khan, Samia Chreim
BMC Public Health.2019;[Epub] CrossRef
County-level radon exposure and all-cause mortality risk among Medicare beneficiaries
Maayan Yitshak-Sade, Annelise J. Blomberg, Antonella Zanobetti, Joel D. Schwartz, Brent A. Coull, Itai Kloog, Francesca Dominici, Petros Koutrakis
Environment International.2019; 130: 104865. CrossRef
Design and testing of a microcontroller that enables alpha particle irradiators to deliver complex dose rate patterns
Tomer Nawrocki, Thomas C Tritt, Prasad V S V Neti, Alex S Rosen, Akhil R Dondapati, Roger W Howell
Physics in Medicine & Biology.2018; 63(24): 245022. CrossRef
Estimates of the Lung Cancer Cases Attributable to Radon in Municipalities of Two Apulia Provinces (Italy) and Assessment of Main Exposure Determinants
Giovanni Ferri, Graziana Intranuovo, Domenica Cavone, Vincenzo Corrado, Francesco Birtolo, Paolo Tricase, Raffaele Fuso, Valeria Vilardi, Marilena Sumerano, Nicola L’abbate, Luigi Vimercati
International Journal of Environmental Research and Public Health.2018; 15(6): 1294. CrossRef
Detection of radon with biosensors based on the lead(II)-induced conformational change of aptamer HTG and malachite green fluorescence probe
Shiya Li, Hongwen Liu, Guiying Yang, Shimeng Liu, Ran Liu, Changyin Lv
Journal of Environmental Radioactivity.2018; 195: 60. CrossRef
Ensuring the Safety and Security of Frozen Lung Cancer Tissue Collections through the Encapsulation of Dried DNA
Kevin Washetine, Mehdi Kara-Borni, Simon Heeke, Christelle Bonnetaud, Jean-Marc Félix, Lydia Ribeyre, Coraline Bence, Marius Ilié, Olivier Bordone, Marine Pedro, Priscilla Maitre, Virginie Tanga, Emmanuelle Gormally, Pascal Mossuz, Philippe Lorimier, Char
Cancers.2018; 10(6): 195. CrossRef

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The variation of thiodiglycolic acid concentration in urine with vinyl chloride exposure levels in rats: Seung Jun Wang, Bong Suk Cha, Jae Hoon Roh, Dong Chun Shin, Myung Su Kim, Keun Jae Jeon; Korean Journal of Occupational and Environmental Medicine 1999;11(4):431-438. Published online December 31, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.4.431

Abstract PDF: OBJECTIVES
It is the objective of this research to identify the variation of thiodiglycolic acid (TdGA) in urine with vinyl chloride monomer (VCM) exposure levels through methylation.
METHODS
After rats were exposed to vinyl chloride monomer of 4 levels, 0 mg/m3, 50 mg /m3, 150 mg/m3, 500 mg/m3, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 24 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done.
RESULTS
In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary .TdGA concentration in urine according to exposure level of VCM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified.
CONCLUSION
TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.

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Short-term Effects of Air Pollution on Hospital Visits for Respiratory Diseases in Seoul: Jong Han Leem, Jong Tae Lee, Dong Gi Kim, Dong Chun Shin, Jae Hoon Roh; Korean Journal of Occupational and Environmental Medicine 1998;10(3):333-342. Published online August 31, 1998; DOI: https://doi.org/10.35371/kjoem.1998.10.3.333

Abstract PDF

Several studies have reported the associations between airborne particles and/or ozone and respiratory diseases. This study examined whether such an association could be seen in Seoul, one of the greatest city in Korea. We compiled daily records of hospital visits in Seoul from November 1, 1995 to October 31, 1996. The daily averages of ozone and particle matter whose diameter is 10 micrometer or less(PM10) from all monitoring stations were computed. Daily respiratory hospital visits were regressed on temperature, humidity, day of weak indicators, seasonal variation indicators, and air pollution. Each pollutant was first examined individually and then two pollutant models were fitted.
RESULTS
: Both PM10 and Ozone were associated with increased risk of respiratory hospital visits. The relative risk of respiratory hospital visits for 50 microgram/m3 increase in PM10(lagged 2 days) was 1.11(95% confidence interval: 1.05-1.18). The PM10 associations was insensitive to alternative methods of control for weather, including exclusion of extreme temperature days and control for temperature on another day. The ozone results were more sensitive to the approach for weather control. The relative risk of respiratory hospital visits for 0.01 ppm increase in O3 was 1.08(95% confidence interval 1.00-1.17). The magnitude of the PM10 effect in Seoul, where SO2 was essential present, was similar to that reported in the Europe and United states. In conclusion, The consistency of investigations of the health effects of air pollution suggest that attention should be paid to the control of air pollution.

Citations

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Status of Ambient PM2.5 Pollution in the Seoul Megacity (2020)
Jung-Hoon Uhm, Eun-Han Kwon, Young-Jun Kim, Ji-Hye Seong, Hyeji Ju, Jun-Hyuk Ahn, Il-Sang Bae, Yong-Suk Choi, Seog-Ju Cho, Yong-Seung Shin
Asian Journal of Atmospheric Environment.2021;[Epub] CrossRef
PM2.5 Source Apportionment Analysis to Investigate Contributions of the Major Source Areas in the Southeastern Region of South Korea
Hyeji Ju, Changhan Bae, Byeong-Uk Kim, Hyun Cheol Kim, Chul Yoo, Soontae Kim
Journal of Korean Society for Atmospheric Environment.2018; 34(4): 517. CrossRef
Particulate Matter from Asian Dust Storms Induces the Expression of Proinflammatory Cytokine in A549 Epithelial Cells
Jung Ho Kim, Hyo Keun Jeon, Mi Kyeong Kim, Sun Yong Kyung, Chang Hyeok An, Sang Pyo Lee, Jung Woong Park, Sung Hwan Jeong
Tuberculosis and Respiratory Diseases.2006; 60(6): 663. CrossRef
Effects of Particulate Matter (PM10) on The Pulmonary Function of Middle-School Children
Jeong Hee Kim, Dea Hyun Lim, Ja Kyoung Kim, Su Jin Jeong, Byong Kwan Son
Journal of Korean Medical Science.2005; 20(1): 42. CrossRef

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Cholinesterase activity and Pestieide Compounds in Blood of Pestieide Sprayers: Dong Chun Shin, Soon Young Lee, Sang Hyuk Chung, Jong Uk Won, Jong Sei Park, Song Ja Park; Korean Journal of Occupational and Environmental Medicine 1994;6(2):402-410. Published online September 30, 1994; DOI: https://doi.org/10.35371/kjoem.1994.6.2.402

Abstract PDF

In order to ascertain the status of health damage among Korean farmers who spray pesticides regularly in summer, blood and urine samples were collected for 88 volunteers during July to Septembei in 1990. Serum cholinesterase activity, parent compounds of pesticides in blood and urine, SGOT, SGPT, blood pressure, pulse rate were measured. The results were as follows ; 1. Mean cholinesterase activity after spraying pesticides was significantly lower than that before splaying. While proportion of abnormal cholinesterase activity (<1900U/L) group was 2.3% before spraying pesticides, tHe proportion of the group after spraying was 22.8% 2. Cholinesterase activity were decreased over 50% in 14.7% of the suhjects who can be classified into poisoning group 3. While pulse rate and blood pressure were slightly increased in poisoning group, those were significantly decreased in non-poisoning group. 4. Consecutive splaying of pesticide caused further reduction of cholinesterase activity, 5. Five parent compounds of pesticides frequently used during summer farming were analyzed using 106 blood samples. IBP in one sample and Isoprothiolane in four samples were detected. No parent compounds were detected in urine samples.

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Overview of Pesticide Poisoning in South Korea
Won Jin Lee, Eun Shil Cha
Journal of Rural Medicine.2009; 4(2): 53. CrossRef

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Effect of Sodium Selenite on Metallothionem Induction by the Treatment of Mercuric Chloride to Rats: Yo Hwan Yang, Hyo Min Lee, Dong Chun Shin, Yong Chung; Korean Journal of Occupational and Environmental Medicine 1989;1(2):236-259. Published online November 30, 1989; DOI: https://doi.org/10.35371/kjoem.1989.1.2.236

Abstract PDF

This study was conducted to investigate the metallothionein induction by sodium selenite in mercuric Chloride intoxication. Mercuric chloride of 3.0 mg/kg of body weight was administered simultaneously with sodium selenite of either a high dosage of 2.5 mg/kg or low dosage of 1mg/kg via intraperitioneal injecion to rats. After the treatment, 6, 12, 24 and 72 hours later, mercury and selenium content in liver and kidney tissues, serum transaminase activities(SGOT, SGPT), metallothionein, glutathione, glutathione peroxidase sotivity and histological changes were determined. The results were summarized as follows on: 1. The combined administration of mercury and selenium significantly more decreased mercury concentrations in liver and kidney compared to the administration of mercury only. 2. The combined administration of mercury and selenium significantly more increased renal metallothionein compared to administration of mercury only. This phenomenon was more remarkable when a large dose(2.5 mg/kg) of selenium was administered with mercuric chloride. 3. Glutathione concentration, glutathione peroxidase activity in liver and kidney and serum transaininase activity(SGOT, SGPT) were less suppressed in the combined administration group than the mercury only group. 4. Histological damage in renal tissue was not revealed in rats treated with mercury and selenium. From the above results, selenium administered simultaneously with mercury decreased mercury concentration in liver and kidney, increased renal metallothionein concentration and decreased the toxicity of mercury. The hypothetic mechanism suggested is that selenium induces the metallothionein combined with Hg and redistributes Hg in tissues.

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Flame retardant polyesters. I. Phosphorous flame retardants
Seung‐Cheol Yang, Jae Pil Kim
Journal of Applied Polymer Science.2007; 106(5): 2870. CrossRef

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