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The Serum Copper and Zinc Concentration according to the Progression of Pneumoconiosis
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Jung Rae Park, Jong Wook Park, Su Ill Lee, Cheol Ho Yi, Cha Jae O, Chang Won Kim, Byung Mann Cho, Don Kyoun Kim
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Korean Journal of Occupational and Environmental Medicine 2000;12(3):384-394. Published online September 30, 2000
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DOI: https://doi.org/10.35371/kjoem.2000.12.3.384
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 Abstract
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- OBJECTIVES
Copper and Zinc, the trace elements of a living body, take a part in immunologic mechanism and induce the pulmonary fibrosis which is the pathologic progress of pneumoconiosis. This study was performed to assist the identification of the pathologic process of pulmonary fibrosis in pneumoconiosis.
METHODS
The subjects of this study was 200 diagnosed persons as pneumoconiosis, of whom 100 persons was the visitors in the outpatients departments of pneumoconiosis and 100 admissive pneumoconiosis patients.
The serum copper and zinc are measured and com pared.
RESULTS
The mean serum copper concentration of visitor group was significantly higher than that of control group, and that of stage V3 subgroup of visitor group was highest because of their advanced fibrosis. But, there was not the difference of serum copper concentration between patient and control group. We thought that the reason was poor nutritional and health status of the patient. The mean of serum zinc concentration of visitor and patient control was lower than that of control group. As the degree of pulmonary fibrosis was more severe from stage Vl, V2, V3 of visitor to stage Pl, P2, P3 of patient, the mean of serum zinc concentration was lower. The ratio of serum copper/zinc of visitor and patient was higher than that of control, and that of patient was higher than that of visitor. Those results showed that the ratio of serum copper/zinc ratio more greatly expressed the degree of progression of pneumoconiosis than only copper or zinc concentration by adjustment of nutritional and health status of the patient.
CONCLUSIONS
As above study results, the degree of pulmonary fibrosis of pneumoconiosis could be estimated by means of serum copper/zinc ratio.
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The Effect of Noise Exposure and Age on the Changes of Group Mean Hearing Threshold Level: Annual Follow-up Studies for Seven Years
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Ji Ho Lee, Choong Ryeol Lee, Cheol In Yoo, Seung Rim Yaang, Ok Hyun Kim, Byung Mann Cho, Su Ill Lee, Don Kyoun Kim
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Korean Journal of Occupational and Environmental Medicine 1999;11(2):137-152. Published online June 30, 1999
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DOI: https://doi.org/10.35371/kjoem.1999.11.2.137
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Abstract
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- This study was carried out to evaluate the effect of noise exposure and age on the changes of group mean hearing threshold level(HTL) over 7-year period. For this purpose, consecutive annual audiometric tests were performed from 1991 to 1997. among 718 male employees of a metal product manufacturing factory. The subjects were divided four groups as follows according to noise level category(NLC). NLC-I officer, exposed noise level was under 60 dB(A) of time weighted average(TWA) NLC-JI technical assistant or engineer, they exposed to workplace noise occasionally NLC-IJJ worker, exposed noise level was below 85 dB(A) of TWA. wore hearing protection device(earmuff or earplug) NLC-IV worker, exposed noise level was over 85 dB(A) of TWA, wore hearing protection device(earmuff and earplug). The results were as follows 1. The improvement of group mean HTL was continued until the fifth year, showing the peak at the third year. The magnitudes of this learning effect were 1.5 - 4.6 dB. 2. The mean HTL of each age group tended to increase after the third year and the tendency was more prominent at 4000 Hz. 3. In noise exposed group(NLC-II, III, and IV), mean HTL increased from the third year after decreasing, meanwhile, in noise free group(NLC-I). it was few changed for the entire period. Among the noise exposure group, the mean HTL of NLC-IV was lower than that of NLC-III and NLC-IV. 4. After learning effect, the mean increase of HTL in noise free group(NLC-I) was 0.4-1.7 dB that suggests aging effect, and that in noise exposure group(NLC-ll, III, and IV) was 0.9 -4.1 dB that suggests noise effect. 5. Statistical analysis of the general linear model implicated that the effect of age was statistically significant at 500, 3000, 4000 and 6000Hz. and the effect of noise exposure was statistically significant at all frequencies except 6000Hz. However, the age * noise interaction was not significant at all frequencies. From these results, it was concluded that the effect of age and noise exposure seems to affect the mean HTL independently and these two factors contribute to an additive effect for the mean HTL change. Furthermore, more concerns should be needed for hearing conservation of low level exposures without any specific protection.
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Citations
Citations to this article as recorded by  - For 5-years the Longitudinal Study on the Effect of Noise Exposure and Aging to the Changes of Hearing Threshold Level
Chang Ho Chae, Ja Hyun Kim, Jun Seok Son
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(4): 573. CrossRef - Prevalence and Risk Factors of Hearing Loss Using the Korean Working Conditions Survey
Kyoo Sang Kim, Oh Jun Kwon
Korean Journal of Audiology.2012; 16(2): 54. CrossRef - Cohort study for the effect of chronic noise exposure on blood pressure among male workers in Busan, Korea
Ji Ho Lee, Weechang Kang, Seung Rim Yaang, Nari Choy, Choong Ryeol Lee
American Journal of Industrial Medicine.2009; 52(6): 509. CrossRef
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A Study on Immunity of Welders
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Su Ill Lee, Bong Soo Cho, Young Wook Kim, Kwang Wook Koh, Won Keun Cho, Young SIl Kim, Soo Yong Kang, In Kyung Hwang, Byung Man Cho, Don Kyoun Kim
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Korean Journal of Occupational and Environmental Medicine 1997;9(1):75-84. Published online February 28, 1997
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DOI: https://doi.org/10.35371/kjoem.1997.9.1.75
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- The authors examined human immunity indicators such as CD4, CD8, Natural Killer (NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studios on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615+/-650 ea/microliter compared with 2,368+/-681 ea/microliter in control group (p<0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37 5+/-9.4%, 24.0+/-8.8%, and 21.0+/-9.5%, respectively, and 35.5+/-6.5%, 25.0+/-6.9%, and 19.6+/-8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. But there was no statistical significance between two groups (p> or =0.05). 3. IgG, IgA, and IgM in welder group were 15.9 mg/dl, 2.7 mg/dl, and 1.5 mg/dl, respectively, and 15.6 mg/dl, 2.9 mg/dl and 1.7 mg/dl in control group. There was no statistical significance between two groups(p> or =0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2+/-1.8 microgram/dl, 0.4+/-0.38 microgram/dl, 1.2+/-0.6 microgram/dl in welder group and 3.2+/-1.7 microgram/dl, 0.44+/-0.29 microgram/dl, 1.1+/-0.6 microgram/dl in control group, respectively, and these value were within normal ranges.
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A Study of the Utility of Mahalanobis Distance for Decision of the Results of Health Examination
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Byung Mann Cho, Don Kyoun Kim
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Korean Journal of Occupational and Environmental Medicine 1994;6(2):270-275. Published online September 30, 1994
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DOI: https://doi.org/10.35371/kjoem.1994.6.2.270
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Abstract
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- In the field of industrial health, it is important to establish the efficient system for health management of workers. The management of health information of workers using data base will contribute to such a system. In this context, the utility of method using Mahalanobis distance(D(2)), the general probability distance in multivariate analysis, for decision of the results of health examination was evaluated.
Six items of test among the health examination data of 278 prospective employee was used to calculate D(2). Sensitively and specificity of decision method using D(2) with 99% normal range was 95.8% and 90.2% respectively as compared with decision by doctor.
This finding suggests the utility of method using D2 for decision of the results of mass screening for industrial workers.
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Alterations of immune response in workers occupationally exposed tolead
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Cheol In Ryu, Byung Mann Cho, Ji Ho Lee, In Kyung Hwang, Su Il Lee, Don Kyoun Kim
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Korean Journal of Occupational and Environmental Medicine 1991;3(2):135-144. Published online November 30, 1991
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DOI: https://doi.org/10.35371/kjoem.1991.3.2.135
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- No abstract available.
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A Study on the Urinary Metabolites and Sister Chromatid Exchanges of Peripheral Lymphocytes in Workers Exposed to the Organic Solvents
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Don Kyoun Kim, In Kyung Hwang, Cheol In Ryu, Su Il Lee, Kap Yul Jung, Yong Hwan Lee, Choong Ryeol Lee, Won Il Hyun, Suk Bong Kim, Yong Duk Jeon
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Korean Journal of Occupational and Environmental Medicine 1990;2(1):75-83. Published online February 28, 1990
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DOI: https://doi.org/10.35371/kjoem.1990.2.1.75
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- In order to know the possibility of utilizing the sister chromatid exchanges as an index which could evaliiate the effect of organic solvents on Lhe health in industrial workers, the authors Studied the effects of the inductivity of sister chromatid exchanges in peripheral lymphocyces from 90 female workers espoxed to organic solvents .and 20 lion-exposed female workers.
The results obtained were as follows: 1. The frequency of sister chromatid exchanges in peripheral iympnocytes from 90 female workers exposed to organic solvents was significantly increased in comparison with 20 coatiol subiect.
2. The frequency of sister chromatid exchanges was significantly Increased in the workers who were employed in the manufacture of plastic materials than the other manufactures.
3. There were no significant differences in the frequency of sister chrornatid exchanges by carriera of the exposed workers.
4. The correlation between the frequency of sister chromatid exchanges and urinary hippuric acid was significant with the coefficient of 0.5902 showing Y=1.867X+15.188 in which Y indicate the frequency of sister chromatid exchanges per cell and X indicate the urinary hippuric acid concentration by g/l.
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