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A Suspicious Case of Chloroform Induced Acute Toxic Hepatitis in Laboratory Worker
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Dae Gwang Lee, Chang Hwan Lee, Keun Ho Jang, Hong Jae Chae, Jai Dong Moon
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Korean Journal of Occupational and Environmental Medicine 2012;24(3):304-310. Published online September 30, 2012
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DOI: https://doi.org/10.35371/kjoem.2012.24.3.304
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 Abstract
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- OBJECTIVES
To report upon a case of toxic hepatitis in a worker exposed to chloroform.
METHODS
A 28-year-old female who had worked as chemical analysis engineer in a laboratory using chloroform was hospitalized due to nausea, vomiting and generalized weakness. The authors evaluated her using blood tests, abdominal CT scan and her occupational history.
RESULTS
The blood tests revealed acute toxic hepatitis. Other causes of hepatitis such as viral, drug induced or alcoholic hepatitis could be excluded. But autoimmune hepatitis couldn't be totally ruled out(ANA (++), IgG(serum) 1780 mg/dL). After admission, her symptoms improved and her liver enzyme levels(AST and ALT) were markedly reduced. She returned to her workplace after discharge. Afterwards, however, her liver enzyme levels increased again one week after returning to her workplace. Subsequent to a job change, her liver enzyme levels reduced and normalized after eight weeks. The airbone laboratory chloroform ranged from 3.155 to 9.037 ppm.
CONCLUSIONS
The authors presume that this patient's liver injury was related to an interaction of chloroform toxicity and a predisposition to autoimmune hepatitis. The rapid improvement of the clinical symptoms and the progressive normalization of the liver function tests once the chloroform exposure eliminated supports the diagnosis.
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Citations
Citations to this article as recorded by  - Recent advances in non-fullerene organic photovoltaics enabled by green solvent processing
Shilin Li, Hong Zhang, Shengli Yue, Xi Yu, Huiqiong Zhou
Nanotechnology.2022; 33(7): 072002. CrossRef - A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef - Aliphatic Halogenated Hydrocarbons: Report and Analysis of Liver Injury in 60 Patients
Rolf Teschke
Journal of Clinical and Translational Hepatology.2018;[Epub] CrossRef - A Study on Fabrication of 3D Dual Pore Scaffold by Fused Deposition Modeling and Salt-Leaching Method
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Transactions of the Korean Society of Mechanical Engineers A.2015; 39(12): 1229. CrossRef - Acute liver injury in two workers exposed to chloroform in cleanrooms: a case report
Young Joong Kang, Jungho Ahn, Yang-In Hwang
Annals of Occupational and Environmental Medicine.2014;[Epub] CrossRef
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