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Original Article
A proposal of spirometry reference equations for Korean workers
Yonglim Won, Hwa-Yeon Lee
Ann Occup Environ Med 2022;34:e14.   Published online June 21, 2022
DOI: https://doi.org/10.35371/aoem.2022.34.e14
AbstractAbstract AbstractAbstract in Korean PDFPubReaderePub
Background

Although spirometry results can be interpreted differently depending on the reference equation used, there are no established criteria for selecting reference equations as part of the special health examinations for Korean workers. Thus, it is essential to examine the current use of reference equations in Korea, quantify their impact on result interpretation, and propose reference equations suitable for Korean workers, while also considering the environmental conditions of special health examination facilities.

Methods

The 213,640 results from the special health examination database were analyzed to identify changes in the ratio of measured values to reference values of lung capacity in Korean workers with changes in age or height, and changes in the agreement of interpretations with the reference equation used. Data from 238 organizations that participated in the 2018–2019 quality control assessment by the Korea Occupational Safety and Health Agency were used to identify the spirometer model and reference equations used in each special health examination facility.

Results

Korean special health examination facilities used six reference equations, and the rate of normal or abnormal ventilatory diagnoses varied with the reference equation used. The prediction curve of the Global Lung Function Initiative 2012-Northeast Asian (GLI2012) equation most resembled that of the normal group, but the spirometry model most commonly used by examination facilities was not compliant with the GLI2012 equation. With a scaling factor of 0.95 applied to the Dr. Choi equation, the agreement with the GLI2012 equation was > 0.81 for men and women.

Conclusions

We propose the GLI2012 equation as reference equation for spirometry in Korean workers. The GLI2012 equation exhibited the most suitable prediction curve against the normal lung function group. For devices that cannot use the GLI2012 equation, we recommend applying a scaling factor of 0.95 to the Dr. Choi equation.

한국인 근로자의 특수건강진단 폐활량검사 결과 해석을 위한 예측식 제안
목적
폐활량검사 결과의 해석은 적용 예측식에 따라 달라질 수 있으나 현재 한국에는 특수건강진단 폐활량검사의 해석을 위한 예측식 선택 기준이 없다. 따라서 한국 특수건강진단기관 전체의 예측식 사용 실태를 파악하여 그것들이 결과 해석에 어느 정도 영향을 주었는지 정량적으로 확인하고, 한국인 근로자에게 적합하며 특수건강진단기관의 현실을 고려한 예측식을 제안할 필요가 있다.
방법
특수건강진단 데이터베이스로부터 추출한 213,640건의 폐활량검사 결과를 분석하여 한국인 근로자의 나이 또는 키의 변화에 따른 폐활량 예측치 대비 측정치의 변화와 예측식 변경에 따른 판정일치도의 변화를 확인하였다. 2018-2019년에 한국산업안전보건공단의 정도관리에 참여했던 238개 기관의 평가자료로부터 각 특수건강진단기관의 폐활량검사기 모델과 예측식 적용실태를 확인하였다.
결과
한국의 특수건강진단기관에서는 6종류의 예측식을 사용하고있었으며, 예측식에 따라 폐활량검사의 정상 또는 이상 판정률에 차이가 있었다. Global Lung Function Initiative 2012-동북아시안식의 예측곡선이 정상선별집단의 분포와 가장 일치하였으나 특수건강진단기관에서 가장 많이 사용하고 있는 검사기 모델에는 GLI 2012식을 적용할 수 없었다. 최정근식에 보정계수 0.95 적용 시 남성과 여성 모두에서 GLI 2012식과의 판정일치도는 0.81이상이었다.
결론
한국인 근로자의 폐활량검사 예측식으로 GLI 2012식을 제안한다. GLI 2012식은 정상 선별집단의 폐활량분포와 가장 일치하는 예측곡선을 그렸다. GLI 2012식을 적용할 수 없는 검사기에는 최정근식에 보정계수 0.95의 적용을 제안한다.

Citations

Citations to this article as recorded by  
  • Spirometry Reference Equations for Asian Migrant Workers in Korea: A Proposal
    Hwa-Yeon LEE, Yonglim WON
    Korean Journal of Clinical Laboratory Science.2023; 55(1): 29.     CrossRef
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  • 1 Crossref
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Research Article
Validation of health screening questionnaire used for screening gastrointestinal disorder in worker's special health examination for night time work
JaeYong Lee, Ji-Won Lee, WonSeon Choi, Jun-Pyo Myong
Ann Occup Environ Med 2019;31:e8.   Published online June 14, 2019
DOI: https://doi.org/10.35371/aoem.2019.31.e8
AbstractAbstract PDFPubReaderePub
Background

Since the night time work was introduced as a ‘harmful factor’ for the worker's special health examination (WSHE) in 2014, the validation of the questionnaire used for screening gastrointestinal (GI) disorder has not been conducted. The purpose of this study is to verify the validity of the questionnaire using the data of specific health screening cluster.

Methods

We used WSHE screening data for 3 years, from 2014 to 2016, in health screening cluster. The subjects who had received upper GI endoscopy in opportunistic screening and WSHE simultaneously regardless of the results of the questionnaire were selected. We tested the validity of the questionnaire using upper GI endoscopy as a gold standard.

Results

This study was conducted on 5,057 examinees in 2014, 8,352 examinees in 2015, and 10,587 examinees in 2016. The validity of the questionnaire for each year was as follows: sensitivity 12.3% (95% confidence interval [CI], 11.1–13.4), specificity 88.6% (95% CI, 87.2–90.1), accuracy 41.1% (95% CI, 39.8–42.5) in 2014, sensitivity 5.9% (95% CI, 5.2–6.5), specificity 93.6% (95% CI, 92.7–94.4), accuracy 38.6% (95% CI, 37.6–39.6) in 2015, sensitivity 6.0% (95% CI, 5.4–6.5), a specificity of 9.42% (95% CI, 93.4–95.0), accuracy of 34.2% (95% CI, 33.3–35.1) in 2016. In generally, questionnaire showed sensitivity of 10%, specificity of 90%, and accuracy of 40%.

Conclusions

Despite the purpose of WSHEs aiming to identify target disease early, the sensitivity of the questionnaire for GI disease was too low as 10%. The reasons for this are the problem of the question itself, and the problem of ambiguous target disease. In the future, the questionnaire should be improved to meet the purpose of the WSHE, and further correction of the target disease should be made.


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Research Article
Blood lead levels of Korean lead workers in 2003–2011
Ji-Hye Kim, Eun-A Kim, Dong-Hee Koh, Kiwhan Byun, Hyang-Woo Ryu, Sang-Gil Lee
Ann Occup Environ Med 2014;26:30-30.   Published online October 1, 2014
DOI: https://doi.org/10.1186/s40557-014-0030-3
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to document the trend in blood lead levels in Korean lead workers from 2003 until 2011 and blood lead levels within each of the main industries.

Methods

Nine years (2003–2011) of blood lead level data measured during a special health examination of Korean lead workers and collected by the Korea Occupational Safety and Health Agency were analyzed. Blood lead levels were determined by year, and a geometric mean (GM) was calculated for each industry division.

Results

The overall GM blood lead level for all years combined (n = 365,331) was 4.35 μg/dL. The GM blood lead level decreased from 5.89 μg/dL in 2003 to 3.53 μg/dL in 2011. The proportion of the results ≥30 μg/dL decreased from 4.3% in 2003 to 0.8% in 2011. In the “Manufacture of Electrical Equipment” division, the GM blood lead level was 7.80 μg/dL, which was the highest among the industry divisions. The GM blood lead levels were 7.35 μg/dL and 6.77 μg/dL in the “Manufacturers of Rubber and Plastic Products” and the “Manufacture of Basic Metal Products” division, respectively.

Conclusions

The blood lead levels in Korean lead workers decreased from 2003 to 2011 and were similar to those in the US and UK. Moreover, workers in industries conventionally considered to have a high risk of lead exposure also tended to have relatively high blood lead levels compared to those in other industries.


Citations

Citations to this article as recorded by  
  • Evaluation of Temporal Trends of Lead Exposure in Korean Workers Using Workplace Monitoring Data
    Dong-Hee Koh, Sangjun Choi, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Inah Kim, Jong-Uk Won, Dae Sung Lim, Hoekyeong Seo, Dong-Uk Park
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • The lead burden of occupational lead-exposed workers in Guangzhou, China: 2006–2019
    Jiabin Liang, Jieyan Cai, Jiaming Guo, Jianping Mai, Liping Zhou, Jinwei Zhang, Yimin Liu, Zhi Wang
    Archives of Environmental & Occupational Health.2022; 77(5): 403.     CrossRef
  • Does Exposure of Lead and Cadmium Affect the Endometriosis?
    Min-Gi Kim, Young-Sun Min, Yeon-Soon Ahn
    International Journal of Environmental Research and Public Health.2021; 18(17): 9077.     CrossRef
  • Chronic Stress and Cardiovascular Disease among Individuals Exposed to Lead: A Pilot Study
    Emmanuel Obeng-Gyasi, Barnabas Obeng-Gyasi
    Diseases.2020; 8(1): 7.     CrossRef
  • Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats
    Yafei Wang, Yuqing Tang, Zhou Li, Qihang Hua, Li Wang, Xin Song, Baobo Zou, Min Ding, Jinshun Zhao, Chunlan Tang
    International Journal of Environmental Research and Public Health.2020; 17(4): 1451.     CrossRef
  • Collective exposure to lead from an approved natural product-derived drug in Korea
    Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
    Annals of Occupational and Environmental Medicine.2019;[Epub]     CrossRef
  • Estimation of Lead Exposure Prevalence in Korean Population through Combining Multiple Experts’ Judgment based on Objective Data Sources
    Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Jae-Oh Park, Dong-Uk Park
    Annals of Work Exposures and Health.2018; 62(2): 210.     CrossRef
  • Mean Blood Lead Level in Iranian Workers: A Systematic and Meta-Analysis
    Milad Azami, Zainab Tardeh, Akram Mansouri, Ali Soleymani, Kourosh Sayehmiri
    Iranian Red Crescent Medical Journal.2018;[Epub]     CrossRef
  • Lead Poisoning at an Indoor Firing Range
    Kyung Wook Kang, Won-Ju Park
    Journal of Korean Medical Science.2017; 32(10): 1713.     CrossRef
  • Occupational Lead Exposure from Indoor Firing Ranges in Korea
    Won-Ju Park, Suk-Ho Lee, Se-Ho Lee, Hye-Sik Yoon, Jai-Dong Moon
    Journal of Korean Medical Science.2016; 31(4): 497.     CrossRef
  • Blood Lead Levels and Cause-Specific Mortality of Inorganic Lead-Exposed Workers in South Korea
    Min-Gi Kim, Jae-Hong Ryoo, Se-Jin Chang, Chun-Bae Kim, Jong-Ku Park, Sang-Baek Koh, Yeon-Soon Ahn, Max Costa
    PLOS ONE.2015; 10(10): e0140360.     CrossRef
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Original Article
Analysis of Korean Analytical Quality Assurance Program for the Special Health Examination from 1995 to 1999
Seong Kyu Kang, Jeong Sun Yang, Mi Young Lee, In Jeong Park, Ho Keun Chung
Korean Journal of Occupational and Environmental Medicine 2000;12(1):139-147.   Published online March 31, 2000
DOI: https://doi.org/10.35371/kjoem.2000.12.1.139
AbstractAbstract PDF
OBJECTIVE: The accuracy of analytical results of blood and urine heavy metals came out to the main issue on occupational health from late eighties. The discrepancy of the results for same samples from different laboratories made the diagnosis for occupational diseases be unreliable. Therefore, a quality control program for analysis of samples taken from workplace had been introduced in Korea since 1992. This study aims to show the quality control program f'or analysis of blood and urine samples and its proficient rates from 1992 to 1999 and to know how they have been being used in occupational health.
METHODS
The quality control program runs twice a year with mandatory items of blood lead and urine hippuvic acid and voluntary items of blood cadmium and manganese and urine mandellic acid and methyl hippuric acid. Participant laboratories are receiving three levels for each items and two out of three samples have to be qualified for being a proficient laboratory for the item. The acceptable range of blood lead and urine hippuric acid is +/-15% and that of the others is within 3 SD(standard deviation) from the reference values.
RESULTS
The proficient rates of blood lead and urine hippuric acid was 89%, 90%, repectively, however those of the other voluntary items have been from 51% to 62%. The proficient rates of urine mercury and urine N-methylformamide(NMF), which are introduced since 1999, were very poor. Urine hippuric acid and blood lead were analyzed frequently for the purpose of biological monitoring conducting by special health examination organizations. Urine and blood manganese and urine metabolites of trichloroethylene, urine phenol, methylhippuric acid and cadmium were followed.
CONCLUSIONS
In conclusion, the quality control program for biological monitoring has dramatically improve the ability of analysing blood and urine samples and eventually contributes to diagnose occupational diseases and to prevent occupational poisoning. However, some biological monitoring data, such as urine manganese, mercury and NMF, have been still reported from laboratories that were not accepted as a proficient laboratory.

Citations

Citations to this article as recorded by  
  • External Quality Assessment Scheme for Biological Monitoring of Occupational Exposure to Toxic Chemicals
    Mi-Young Lee, Jeong Sun Yang, Seong-Kyu Kang
    Safety and Health at Work.2011; 2(3): 229.     CrossRef
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  • 1 Crossref
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Original Article
A Study on Possibility of Special Health Examination to the Hospital Employees
Su Ill Lee, Byung Mann Cho, Bong Soo Cho, Young Wook Kirn, Kwang Wook Koh, Nam Chool Moon, Joo Won Kirn
Korean Journal of Occupational and Environmental Medicine 1996;8(2):191-200.   Published online September 30, 1996
DOI: https://doi.org/10.35371/kjoem.1996.8.2.191
AbstractAbstract PDF
This study was performed to decide the possibility of special health examination to the hospital employees. We carried out questionnaire survey for 830 subjects at 2 general hospitals located in Pusan city. The summary of this study are as follows. 1. Above 10% of total hospital employees were replied that they exposed to 16 hazard items, such as dust, noise, stress and etc. Among them, over 50% of hospital employees exposed to dust(69.8%), noise(52.3%), stress(60.1%). And hospital employees exposed to alcoholic disinfectant(41.3%), radiation(34.6%), drug(33.3%), VDT(25.2%), and aldehyde(18.7%) also. 2. 63% of the hospital employees replied that there were hazardous factors in hospital environments, and 80% insisted the necessity for hospital environment measuring. 35.7% of respondents replied that they had never taken the education about hazardous factors. 35.7% of the total respondents answered that they didn't use protective equipment when exposed to hazardous factors. And 48.6% answered they took periodic health examination. Only 7.2% replied that ventilation condition of office room was proper. As shown in above results, hospital employees are exposed to various hazards, and turn out neglecting to health problems caused these hazardous factors. So at first, it is necessary to measuring hospital working environment, and then will be decided the possibility of special health examination to the hospital employees.

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