Annals of Occupational and Environmental Medicine

Case Report

An aggravated return-to-work case of organic solvent induced chronic toxic encephalopathy: Sangyun Seo, Jungwon Kim; Ann Occup Environ Med 2018;30:27. Published online April 27, 2018; DOI: https://doi.org/10.1186/s40557-018-0232-1

Background

Organic solvent-induced chronic toxic encephalopathy (CTE) is known as a non-progressive disorder that does not progress after diagnosis. The authors present a case those symptoms worsened after continued exposure to organic solvent after returning to work. Because such a case has not been reported in South Korea to the best of our knowledge, we intend to report this case along with literature review.

Case presentation

A 59-year-old man, who performed painting job at a large shipyard for 20 years, was receiving hospital treatment mainly for depression. During the inpatient treatment, severe cognitive impairment was identified, and he visited the occupational and environmental medicine outpatient clinic for assessing work relatedness. In 1984, at the age of 27, he began performing touch-up and spray painting as a shipyard painter. Before that he had not been exposure to any neurotoxic substances. In 2001, at the age of 44, after 15 years of exposure to mixed solvents including toluene, xylene and others, he was diagnosed with CTE International Solvent Workshop (ISW) type 2A. After 7 years of sick leave, he returned to work in 2006. And he repeated return-to-work and sick leave in the same job due to worsening of depressive symptoms. He had worked four times (2006–2010, 2011–2011, 2011–2011, 2016–2017) for a total of 5 years as a shipyard painter after first compensation. During the return-to-work period, the mean values of the mixed solvent index ranged from 0.57 to 2.15, and except for a one semiannual period, all mean values were above the standard value of 1. We excluded other diseases that can cause cognitive impairment like central nervous system diseases, brain injury, psychological diseases and metabolic diseases with physical examinations, laboratory tests, and brain image analysis. And finally, throughout neuropsychological tests, an overall deterioration in cognitive function was identified compared to 2002, and the deterioration types was similar to that often shown in the case of CTE; thus a diagnosis of CTE (ISW) type 3 was made.

Conclusion

This case is showing that CTE can go on with continued exposure to mixed solvents. Appropriate “fitness to work” should be taken to prevent disease deterioration especially for the sick leave workers.

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Review

Manganese Neurotoxicity: a Focus on Glutamate Transporters: Pratap Karki, Eunsook Lee, Michael Aschner; Ann Occup Environ Med 2013;25:4-4. Published online May 21, 2013; DOI: https://doi.org/10.1186/2052-4374-25-4

Abstract PDF PubReader ePub

Manganese (Mn) is an essential element that is required in trace amount for normal growth, development as well maintenance of proper function and regulation of numerous cellular and biochemical reactions. Yet, excessive Mn brain accumulation upon chronic exposure to occupational or environmental sources of this metal may lead to a neurodegenerative disorder known as manganism, which shares similar symptoms with idiopathic Parkinson’s disease (PD). In recent years, Mn exposure has gained public health interest for two primary reasons: continuous increased usage of Mn in various industries, and experimental findings on its toxicity, linking it to a number of neurological disorders. Since the first report on manganism nearly two centuries ago, there have been substantial advances in the understanding of mechanisms associated with Mn-induced neurotoxicity. This review will briefly highlight various aspects of Mn neurotoxicity with a focus on the role of astrocytic glutamate transporters in triggering its pathophysiology.

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Komang Trisna Sumadewi, Bryan Gervais de Liyis, Ni Made Linawati, I Putu Eka Widyadharma, I Nyoman Mantik Astawa
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Experimental Brain Research.2023; 241(1): 201. CrossRef
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Fajuan Tang, Lin Chen, Hu Gao, Yupeng Lei, Linli Pan, Dongqiong Xiao, Xihong Li
Neurochemical Research.2023; 48(3): 791. CrossRef
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Journal of Chemistry.2021; 2021: 1. CrossRef
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Yan Feng, Shifang Zhou, Jian Sun
Experimental Brain Research.2021; 239(11): 3277. CrossRef
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Micellar buccal film for safe and effective control of seizures: Preparation, in vitro characterization, ex vivo permeation studies and in vivo assessment
Alaa H. Salama, Mona Basha, Abeer A.A. Salama
European Journal of Pharmaceutical Sciences.2021; 166: 105978. CrossRef
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Ali Farzin, Seyed Alireza Etesami, Jacob Quint, Adnan Memic, Ali Tamayol
Advanced Healthcare Materials.2020;[Epub] CrossRef
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Xiang Chen, Zhenfang Liu, Xiaoting Ge, Xiaoyu Luo, Sifang Huang, Yanting Zhou, Defu Li, Hong Cheng, Longman Li, Lulu Huang, Qingzhi Hou, Gaohui Zan, Yanli Tan, Chaoqun Liu, Yunfeng Zou, Xiaobo Yang
Journal of Trace Elements in Medicine and Biology.2020; 59: 126454. CrossRef
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I. V. Smolensky, S. V. Ovsepian, A. V. Zaitsev
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International Journal of Molecular Sciences.2019; 20(23): 5852. CrossRef
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Journal of Molecular Structure.2018; 1166: 102. CrossRef
Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes
Souvarish Sarkar, Emir Malovic, Dilshan S. Harischandra, Hilary A. Ngwa, Anamitra Ghosh, Colleen Hogan, Dharmin Rokad, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy
NeuroToxicology.2018; 64: 204. CrossRef
The Impact of Environmental Mn Exposure on Insect Biology
Yehuda Ben-Shahar
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Metabolic Brain Disease.2017; 32(5): 1675. CrossRef
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Inorganic Chemistry.2017; 56(11): 6076. CrossRef
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Mycorrhiza.2016; 26(5): 475. CrossRef
Null allele mutants of trt-1 , the catalytic subunit of telomerase in Caenorhabditis elegans , are less sensitive to Mn-induced toxicity and DAergic degeneration
Omamuyovwi M. Ijomone, Mahfuzur R. Miah, Tanara V. Peres, Polycarp U. Nwoha, Michael Aschner
NeuroToxicology.2016; 57: 54. CrossRef
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PLOS ONE.2015; 10(9): e0138270. CrossRef
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Toxicological Sciences.2015; 143(2): 454. CrossRef
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Robyn M. Amos-Kroohs, Colin P. Bloor, Momina A. Qureshi, Charles V. Vorhees, Michael T. Williams
Toxicology Reports.2015; 2: 1046. CrossRef
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Case Report

A Case of Acute Organotin Poisoning: Yu Jung Kim, Yangho Kim, Kyoung Sook Jeong, Chang Sun Sim, Nari Choy, Jongchul Kim, Jun Bum Eum, Yoshiaki Nakajima, Yoko Endo, Cheol In Yoo; Korean Journal of Occupational and Environmental Medicine 2006;18(3):255-262. Published online September 30, 2006; DOI: https://doi.org/10.35371/kjoem.2006.18.3.255

Abstract PDF

BACKGROUND
Although organotin compounds are widely used as PVC stabilizers, catalysts and biocides, their effects on humans are not well known. However, their acute intoxication is known to cause neurotoxicity in the central nervous system, renal toxicity, and hepatotoxicity. As there has been no previously published case of organotin intoxication in Korea, we report here the first Korean case of acute exposure to organotin.
CASE
REPORT: A 43-year-old male with disorientation and behavioral change was admitted to a hospital. He had been working as a tank cleaner for several different companies in the previous 8 years and a week before admission, he had cleaned a tank containing dimethyltin (DMT) for 4 days. A day after finishing the job, he suffered decreased memory, behavioral change and progressive mental deterioration when he arrived at the emergency room. The result of spinal tapping was negative but on the 4th day of admission he deteriorated into a state of coma along with metabolic acidosis and severe hypokalemia. High levels of DMT and trimethyltin (TMT) were detected in a highly sensitive urine analysis. After conservative treatment and chelation therapy, the patient showed some clinical improvement but the neurological defects persisted.
CONCLUSION
The patient appeared to have been intoxicated from the acute exposure to a high level of organotin while cleaning the tank.

Citations

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Acute Occupational Poisoning in Korea
Hyunjoo Kim, Jia Ryu
The Ewha Medical Journal.2016; 39(4): 99. CrossRef
Compensation for Occupational Diseases by Chemical Agents in Korea
Soon-Chan Kwon, Soo-Yong Roh, Ji-Hoon Lee, Eun-A Kim
Journal of Korean Medical Science.2014; 29(Suppl): S78. CrossRef
Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Occupational Neurologic Disorders in Korea
Yangho Kim, Kyoung Sook Jeong, Yong-Hun Yun, Myoung-Soon Oh
Journal of Clinical Neurology.2010; 6(2): 64. CrossRef

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