Annals of Occupational and Environmental Medicine

Youngwoo Jin

3 Articles

Factors Associated with Psychoneurobehavjral Outcomes in Workers Exposed to Manganese: Kyoo Sang Kim, Yangho Kim, Youngwoo Jin, Euna Kim, Jeong Sun Yang, Kwi Ryun Kwon, Jae Woo Kim, Jaehoon Roh, Young Hahn Moon; Korean Journal of Occupational and Environmental Medicine 1999;11(2):213-228. Published online June 30, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.2.213

The risk posed to human health by environmental manganese (Mn) exposure is unknown. The purpose of this study is to establish if subclinical effects related to Mn exposure and examine the factors influencing psychoneurobehaviral outcomes of Mn exposed workers. This study involved 121 male workers of welding, alloy furnace, and manufacturing of welding stick. Study investigations include: a questionnaire covering demographic characteristics, job and exposure history and medical symptoms and conditions, monitoring workplace air for personal exposure to respirable and inhalable manganese, analysis of blood and urine samples. psychoneurobehaviral test(neurobehaviral core test battery (NCTB), signal change on magnetic resonance imaging (MRJ) scans, minimental state and neurological examination). The main results of this study were as follows: 1. Preliminary results showed that, with increasing manganese exposure, neurobehaviral performance was poorer and signal change on MRI scans increased. 2. The results of examination revealed significant relations on psychoneurobehaviral out-comes (neurobehaviral performance, signal change on MRI scans, and neurological features). 3. In multiple regression, age and educational status as demographic variables and exposure level were significantly related to 4neurobehaviral test. Also exposure level and serum Mn concentrations were positively relatel to signal change on MRI scans and neurological features affected by Mn on the brain (signal change). 4. Psychoneurobehaviral outcomes from Mn exposure were related to neurobehaviral performance, signal change on MRJ scans, neurological features and profile of mood states (POMS), and influnced positively with age, alcohol and smoking history, and duration of Mn exposure, negatively with educational status. Serum Mn concentrations in combination with brain MRI scans, and perhaps a battery of neurobehaviral tests, appear to be the best way to monitor excessive exposure to Mn. These results are consistent with our knowledge on Mn action on the brain and are similar to the type of neurobehaviral dysfunction. They suggest that there may be age, educational status, and life style (alcohol and drinking history) differences with chronic environmental exposure. These findings suggest further evaluation, particularly on relationships between Mn exposure, aging, and susceptibility factors.

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A Study on the Total, Particle Size-Selective Mass Concentration of Airborne Manganese, and Blood Manganese Concentration of Welders in a Shipbuilding Yard
Jong Su Park, Pan Gyi Kim, Jee Yeon Jeong
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(4): 472. CrossRef
Associations between Airborne Manganese and Blood Manganese in the Korean General Population according to KNHANES 2008-2009
Kyung Sick Jung, Jong Dae Lee, Yong Bae Kim
Journal of Environmental Science International.2013; 22(12): 1589. CrossRef
Neurobehavioral Deficits and Parkinsonism in Occupations with Manganese Exposure: A Review of Methodological Issues in the Epidemiological Literature
Robert M. Park
Safety and Health at Work.2013; 4(3): 123. CrossRef
Olfactory functions at the intersection between environmental exposure to manganese and Parkinsonism
Silvia Zoni, Giulia Bonetti, Roberto Lucchini
Journal of Trace Elements in Medicine and Biology.2012; 26(2-3): 179. CrossRef
Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Exposure-Response Relationship and Risk Assessment for Cognitive Deficits in Early Welding-Induced Manganism
Robert M. Park, Rosemarie M. Bowler, Harry A. Roels
Journal of Occupational & Environmental Medicine.2009; 51(10): 1125. CrossRef
State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk?
Annette B. Santamaria, Colleen A. Cushing, James M. Antonini, Brent L. Finley, Fionna S. Mowat
Journal of Toxicology and Environmental Health, Part B.2007; 10(6): 417. CrossRef
Issues in neurological risk assessment for occupational exposures: The Bay Bridge welders
Robert M. Park, Rosemarie M. Bowler, Donald E. Eggerth, Emily Diamond, Katie J. Spencer, Donald Smith, Roberto Gwiazda
NeuroToxicology.2006; 27(3): 373. CrossRef
Potential occupational risks for neurodegenerative diseases
Robert M. Park, Paul A. Schulte, Joseph D. Bowman, James T. Walker, Stephen C. Bondy, Michael G. Yost, Jennifer A. Touchstone, Mustafa Dosemeci
American Journal of Industrial Medicine.2005; 48(1): 63. CrossRef

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Performance of Neurobehavioral Tests Among Welders Exposed to Manganese: Youngwoo Jin, Yangho Kim, Kyoo Sang Kim, Euna Kim, Young Sook Cho, Yong Chul Shin, Changho Chai, Younghyu Choi, Se Hoon Lee, Young Hahn Moon; Korean Journal of Occupational and Environmental Medicine 1999;11(1):1-12. Published online March 31, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.1.1

Abstract PDF

To study neurobehavioral effects for manganese fume exposure of welders, we administrated questionnaire about subjective symptom, related with manganese exposure. Neurobehavioral Core Test Battery of World Health Qrganization(NCTB) and finger tapping for 98 welders and 29 non-welding workers. We adopted welding duration as a criterion for exposure assessment, because of the lack of the longitudinal valid data and differences in airborne concentrations of manganese in welding types, such as shielded metal arc and CO2 arc welding. Neurologic, musculoskeletal and concentration symptoms were significantly increased by increase of welding duration. Performance of finger tapping preferred hand, Santa Ana dexterity test preferred hand and correct number of pursuit aiming were significantly decreased by increase of welding duration. These results comparable with previous studies that suggest neurobehavioral test, especially motor test, to be an appropriate tool to detect early neurobehavioral abnormalities related with manganeses exposure.

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Manganese exposure and cognitive performance: A meta-analytical approach
Thomas Vlasak, Tanja Dujlovic, Alfred Barth
Environmental Pollution.2023; 332: 121884. CrossRef
Derivation of an occupational exposure level for manganese in welding fumes
Lisa A. Bailey, Laura E. Kerper, Julie E. Goodman
NeuroToxicology.2018; 64: 166. CrossRef
Neurobehavioral Deficits and Parkinsonism in Occupations with Manganese Exposure: A Review of Methodological Issues in the Epidemiological Literature
Robert M. Park
Safety and Health at Work.2013; 4(3): 123. CrossRef
Neuropsychological effects of low-level manganese exposure in welders
Wisanti Laohaudomchok, Xihong Lin, Robert F. Herrick, Shona C. Fang, Jennifer M. Cavallari, Ruth Shrairman, Alexander Landau, David C. Christiani, Marc G. Weisskopf
NeuroToxicology.2011; 32(2): 171. CrossRef
Occupational Psychiatric Disorders in Korea
Kyeong-Sook Choi, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S87. CrossRef
Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Exposure-Response Relationship and Risk Assessment for Cognitive Deficits in Early Welding-Induced Manganism
Robert M. Park, Rosemarie M. Bowler, Harry A. Roels
Journal of Occupational & Environmental Medicine.2009; 51(10): 1125. CrossRef
State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk?
Annette B. Santamaria, Colleen A. Cushing, James M. Antonini, Brent L. Finley, Fionna S. Mowat
Journal of Toxicology and Environmental Health, Part B.2007; 10(6): 417. CrossRef
High signal intensity on magnetic resonance imaging as a predictor of neurobehavioral performance of workers exposed to manganese
Yong Chul Shin, Euna Kim, Hae-Kwan Cheong, Sungil Cho, Joon Sakong, Kyoo Sang Kim, Jung Sun Yang, Young-Woo Jin, Seong-Kyu Kang, Yangho Kim
NeuroToxicology.2007; 28(2): 257. CrossRef
Sequelae of fume exposure in confined space welding: A neurological and neuropsychological case series
Rosemarie M. Bowler, Sanae Nakagawa, Marija Drezgic, Harry A. Roels, Robert M. Park, Emily Diamond, Donna Mergler, Maryse Bouchard, Russell P. Bowler, William Koller
NeuroToxicology.2007; 28(2): 298. CrossRef
Issues in neurological risk assessment for occupational exposures: The Bay Bridge welders
Robert M. Park, Rosemarie M. Bowler, Donald E. Eggerth, Emily Diamond, Katie J. Spencer, Donald Smith, Roberto Gwiazda
NeuroToxicology.2006; 27(3): 373. CrossRef

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Polyneuropathy by Occupational Exposure to Acrylamide: Hae Kwan Cheong, Yong Wook Kwon, Kyung Yun Uh, Byung Joon Kim, Jeong Sun Yang, Cheol Jung, Youngwoo Jin, Mi Young Lee, Seong Kyu Kang; Korean Journal of Occupational and Environmental Medicine 1998;10(3):388-403. Published online August 31, 1998; DOI: https://doi.org/10.35371/kjoem.1998.10.3.388

Abstract PDF

Authors report a first Korean case of polyneuropathy in an acrylamide producing factory together with an environmental and epidemiologic survey for the ten workers of the same workplace and 46 workers in the production and manufacturing acrylamide in Ulsan, Korea. The case is 30 years old man who worked in the prcduction of the acrylamide for two years. In August, 1997, he had a weakness of the lower extremity with loss of body weight of 15 Kg which progressed to paresthesia of the limbs, the loss of vibration sense, difficulty in walking, speech disturbance, dysuria, constipation, difficulty in erection and swallowing difficulty. Neurologic examination showed a complete loss of vibration and position sense, and loss of deep tendon reflex in all the limbs. There was a contact dermatitis-like skin lesion on the feet. Electrodiagnostic test showed a generalized polyneuropathy of moderate degree involving motor and sensory component of peripheral and cranial nerves. After 8 months' cessation from exposure and supportive care, his symptoms were completely resolved, but abnormality in electrodiagnostic test and vibrotactile perception threshold still persisted, although much improved than before. There were 11 workers in the same workplace of the case, producing acrylamide by microorganism as a catalyst. Environmental monitoring of the workplace revealed air-borne concentration of the acrylamide to be from 0.05 to 0.23 mg/m(3) by personal sampling and from 7.65 to 11.65 mg/m(3) by area sampling during filter exchanging process, which far exceeds TLV-TWA of 0.03 mg/m(3). However acrylamide was not detected from the plasma of the workers. Symptom questionnaire showed a markedly higher complain of neurologic symptoms, compared to the workers of the other acrylamide producing companies. Electrodiagnostic test showed a several workers are in the lower normal range without definite abnormality. Vibrotactile perception threshold by Vibratron II showed a significantly increased threshold in the workers of the same workplace compared to the other acrylamide workers and significantly decreased test score of color vision compared to normal controls. After improvement of the production process and strict wearing of the protective device, most workers reported the improvement of clinical symptoms, but vibrotactile perception threshold was not improved. These result suggests the need for the effective environmental monitoring together with a periodic biological monitoring. Development of effective screening test is urgently needed to control and assess the skin absorption of acrylamide.

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Dermal and neural toxicity caused by acrylamide exposure in two Korean grouting workers: a case report
Heeyun Kim, Sang Gil Lee, Jeongbae Rhie
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
Occupational Neurologic Disorders in Korea
Yangho Kim, Kyoung Sook Jeong, Yong-Hun Yun, Myoung-Soon Oh
Journal of Clinical Neurology.2010; 6(2): 64. CrossRef
Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Occupational Diseases in Korea
Seong-Kyu Kang, Eun A Kim
Journal of Korean Medical Science.2010; 25(Suppl): S4. CrossRef

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