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Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol
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Seng-Ho Song, Seong-Kyu Kang, Won-Jun Choi, Kyeong Min Kwak, Dong-Hoon Lee, Dyuk-Yoon Kang, Sang-Ha Lee
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Ann Occup Environ Med 2017;29:54. Published online November 7, 2017
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DOI: https://doi.org/10.1186/s40557-017-0210-z
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Abstract
PDFPubReaderePub
- Background
Studies on the hematologic toxicity of ethylene glycol ethers in humans are limited. Therefore, the aim of this study was to examine the association between exposure to solvents (containing 2-butoxyethanol and 2-ethoxyethanol) and hematological effects. MethodsThirty-four screen-printing workers who were exposed to 2-butoxyethanol and 2-ethoxyethanol and 37 non-exposed clerical workers were selected using data from the health care facilities that provided regular health screening services. Student’s t-tests and Pearson’s chi-square tests were used to compare differences in hematological parameters between the exposed and the control groups. A multivariate analysis was performed using the multiple logistic regression models to adjust for other variables. ResultsThe chi-square test showed the reticulocyte percentages and corrected reticulocyte counts to be significantly higher in the exposed group. The t-tests showed a significant increase in white blood cell counts, reticulocyte percentages, and corrected reticulocyte count (i.e., reticulocyte index) in the exposed group, with p-values of 0.002, 0.004, and 0.002, respectively. Multivariate analysis showed the odds ratio for the corrected reticulocyte counts to be 16.30 for the exposed group, when compared with that of the control group. ConclusionsExposure to 2-butoxyethanol and 2-ethoxyethanol was significantly associated with reticulocytosis, necessitating the implementation of preventive measures for workers prone to occupational exposure to ethylene glycol ethers.
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- Hepcidin is not essential for mediating testosterone's effects on erythropoiesis
W. Guo, P. J. Schmidt, M. D. Fleming, S. Bhasin Andrology.2020; 8(1): 82. CrossRef - Cleaning workers’ exposure to volatile organic compounds and particulate matter during floor polish removal and reapplication
Joonas Ruokolainen, Marko Hyttinen Journal of Occupational and Environmental Hygiene.2019; 16(10): 685. CrossRef
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Overlap syndrome with Sjögren’s syndrome and systemic sclerosis in a steel rolling mill worker: a case report
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Min-Kee Yi, Won-Jun Choi, Sung-Woo Han, Seng-Ho Song, Dong-Hoon Lee, Sun Young Kyung, Sang-Hwan Han
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Ann Occup Environ Med 2016;28:24. Published online June 2, 2016
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DOI: https://doi.org/10.1186/s40557-016-0106-3
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Abstract
PDFPubReaderePub
- Background
There are few reports about work-related factors associated with Sjögren’s syndrome. We report a case of overlap syndrome with Sjögren’s syndrome and systemic sclerosis. Case presentationA 54-year-old man was admitted due to dyspnea on exertion. The results of physical examination and laboratory findings were compatible with Sjögren’s syndrome with systemic sclerosis. The patient had no pre-existing autoimmune disease, and denied family history of autoimmune disease. The patient worked in the large-scale rolling department of a steel manufacturing company for 25 years. Hot rolling is a rolling process performed at between 1100 °C and 1200 °C, generating a high temperature and a large amount of fumes, involving jet-spraying of water throughout the process to remove the instantaneously generated oxide film and prevent the high generation of fumes. In this process, workers could be exposed to silica produced by thermal oxidation. Other potential toxic substances including nickel and manganese seemed to be less likely associated with the patient’s clinical manifestations. ConclusionsOccupational exposure to silica seemed to be associated with the patient’s clinical manifestations of overlap syndrome with Sjögren’s syndrome and systemic sclerosis. Although the underlying mechanism is still unclear, autoimmune disease including Sjögren’s syndrome affects women more often than men and there was no family history of autoimmune disease. These suggested that there was an association between occupational silica exposure and the disease of the patient. Future research about the association between long-term low dose exposure to silica and the development of autoimmune diseases should be encouraged.
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Citations
Citations to this article as recorded by
- Environmental pollutants and phosphoinositide signaling in autoimmunity
Chang Ren, Noah D. Carrillo, Vincent L. Cryns, Richard A. Anderson, Mo Chen Journal of Hazardous Materials.2024; 465: 133080. CrossRef - Silicosis y síndrome de Sjögren
Miguel Martín Asenjo, Javier Miguel Martín Guerra, Claudia Iglesias Pérez, José María Prieto de Paula Archivos de Bronconeumología.2019; 55(10): 536. CrossRef - Silicosis and Sjögren's Syndrome
Miguel Martin Asenjo, Javier Miguel Martín Guerra, Claudia Iglesias Pérez, José Maria Prieto de Paula Archivos de Bronconeumología (English Edition).2019; 55(10): 536. CrossRef - Systemic sclerosis due to crystalline silica exposure among jewelry workers in Korea: two case reports
Jae Yoon Kim, Sang Yoon Do, Young Hoon Moon, Chul Gab Lee, Yun Sung Kim, Byung Soon Choi, Eun-A Kim, Han Soo Song Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
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Acute respiratory symptoms and evacuation-related behavior after exposure to chlorine gas leakage
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Sung-Woo Han, Won-Jun Choi, Min-Kee Yi, Seng-Ho Song, Dong-Hoon Lee, Sang-Hwan Han
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Ann Occup Environ Med 2016;28:29. Published online July 4, 2016
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DOI: https://doi.org/10.1186/s40557-016-0115-2
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Abstract
PDFPubReaderePub
- Background
A study was performed on the accidental chlorine gas leakage that occurred in a factory of printed circuit boards manufactured without chlorine. Health examination was performed for all 52 workers suspected of exposure to chlorine gas, and their evacuation-related behaviors were observed in addition to analyzing the factors that affected the duration of their acute respiratory symptoms. MethodsBehavioral characteristics during the incidence of the accidental chlorine gas leakage, the estimated time of exposure, and the duration of subjective acute respiratory symptoms were investigated. In addition, clinical examination, chest radiography, and dental erosion test were performed. As variables that affected the duration of respiratory symptoms, dose group, body weight, age, sex, smoking, work period, and wearing a protective gear were included and analyzed by using the Cox proportional hazard model. ResultsOf 47 workers exposed to chlorine gas, 36 (77 %) developed more than one subjective symptom. The duration of the subjective symptoms according to exposure level significantly differed, with a median of 1 day (range, 0–5 days) in the low-exposure group and 2 days (range, 0–25 days) in the high-exposure group. Among the variables that affected the duration of the acute respiratory symptoms, which were analyzed by using the Cox proportional hazard model, only exposure level was significant (hazard ratio 2.087, 95 % CI = 1.119, 3.890). Regarding the evacuation-related behaviors, 22 workers (47 %) voluntarily evacuated to a safety zone immediately after recognizing the accidental exposure, but 25 workers (43 %) delayed evacuation until the start of mandatory evacuation (min 5, max 25 min). ConclusionsThe duration of the subjective acute respiratory symptoms significantly differed between the low- and high-exposure groups. Among the 27 workers in the high-exposure group, 17 misjudged the toxicity after being aware of the gas leakage, which is a relatively high number.
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Citations
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- Migration behavior of chlorine and sulfur during gasification and combustion of biomass and coal
Yuefeng Wang, Yuhong Qin, Stanislav V. Vassilev, Chong He, Christina G. Vassileva, Yuexing Wei Biomass and Bioenergy.2024; 182: 107080. CrossRef - Acute chlorine poisoning caused by an accident at a swimming pool
Wu Na, Yiran Wang, An Li, Xiaoli Zhu, Changjiang Xue, Qiao Ye Toxicology and Industrial Health.2021; 37(9): 513. CrossRef - Removal of gaseous elemental mercury by hydrogen chloride non-thermal plasma modified biochar
Jinjing Luo, Mingchang Jin, Lurong Ye, Yinan Cao, Yonggui Yan, Rupeng Du, Ryo Yoshiie, Yasuaki Ueki, Ichiro Naruse, ChinJung Lin, YiYuan Lee Journal of Hazardous Materials.2019; 377: 132. CrossRef
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