Annals of Occupational and Environmental Medicine

Jin-Hyun Yu

4 Articles

Risks of borderline liver enzyme abnormalities to the incidence of impaired fasting glucose and diabetes mellitus: a 7 year follow up study of workers: Jin-Hyun Yu, Jin-Seok Kim, Mee-Ra Lee, Seong-Yong Yoon, Seong-Yong Cho, Seung-Hyun Yoo, Boo-Il Kim; Ann Occup Environ Med 2016;28:18. Published online April 7, 2016; DOI: https://doi.org/10.1186/s40557-016-0105-4

Background

The aim of this study was to identify the relationships between borderline serum liver enzyme abnormalities and the incidence of impaired fasting glucose (IFG) and diabetes mellitus (DM) during a 7-year follow-up of workers, and to evaluate the quantitative level of risks.

Methods

A total of 749 workers in an electronics manufacturing company were divided into the normal fasting blood glucose (n = 633), IFG (n = 98), and DM (n = 18) groups, according to the results of their health checkup in 2006. Among 633 workers in the normal group, excluding 55 workers who were impossible to follow, incidence rate and relative risks of 578 workers to the IFG or DM in 2013 according to the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (γ-GTP) were investigated. The liver enzyme levels were categorized as A (normal), B (borderline elevation), and R (definite elevation) following the standard of the National Health Insurance Service of Korea.

Results

The incidence rate of IFG or DM based on ALT level was 9.7 % for the A, 30.0 % for B, and 15.4 % for R. According to γ-GTP, the incidence rate was 9.8 % for A, 34.5 % for B, and 25.0 % for R. The relative risk(RR) to the incidence of IFG or DM depending on the level of ALT were 3.09 in B and 1.59 in R compared to A. According to γ-GTP, RR was 3.52 in B and 2.55 in R compared to A. AST level was not related to the incidence of IFG or DM. A multiple logistic regression analysis with the incidence of IFG or DM as a dependent variable resulted in an odds ratio of 2.664(1.214–5.849) for B level ALT, 3.685(1.405–9.667) for B level of γ-GTP even after adjustment for other variables such as age, sex, body mass index, AUDIT score, systolic blood pressure, and triglyceride.

Conclusions

Even borderline elevations of ALT and γ-GTP, but not AST, increased the incidence and risk of IFG or DM after 7 years. Borderline elevation of ALT and γ-GTP was identified as an independent risk factor of IFG or DM.

Citations

Citations to this article as recorded by

Considering serum alanine aminotransferase and gamma-glutamyltransferase levels together strengthen the prediction of impaired fasting glucose risk: a cross-sectional and longitudinal study
Ji Hye Jeong, Susie Jung, Kyu-Nam Kim
Scientific Reports.2021;[Epub] CrossRef
Association of liver enzymes levels with fasting plasma glucose levels in Southern China: a cross-sectional study
Ling-Ling Huang, Dong-Hui Guo, Hui-Yan Xu, Song-Tao Tang, Xiao Xiao Wang, Yong-Ping Jin, Peixi Wang
BMJ Open.2019; 9(10): e025524. CrossRef
Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study
Gyuri Kim, Suk-Yong Jang, Chung Mo Nam, Eun Seok Kang
Journal of Hepatology.2018; 68(3): 476. CrossRef

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Acute health effects of accidental chlorine gas exposure: Joo-An Kim, Seong-Yong Yoon, Seong-Yong Cho, Jin-Hyun Yu, Hwa-Sung Kim, Gune-Il Lim, Jin-Seok Kim; Ann Occup Environ Med 2014;26:29-29. Published online October 1, 2014; DOI: https://doi.org/10.1186/s40557-014-0029-9

Abstract PDF PubReader ePub

Objectives

This study was conducted to report the course of an accidental release of chlorine gas that occurred in a factory in Gumi-si, South Korea, on March 5, 2013. We describe the analysis results of 2 patients hospitalized because of chlorine-induced acute health problems, as well as the clinical features of 209 non-hospitalized patients.

Methods

We analyzed the medical records of the 2 hospitalized patients admitted to the hospital, as well as the medical records and self-report questionnaires of 209 non-hospitalized patients completed during outpatient treatment.

Results

Immediately after the exposure, the 2 hospitalized patients developed acute asthma-like symptoms such as cough and dyspnea, and showed restrictive and combined pattern ventilatory defects on the pulmonary function test. The case 1 showed asthma-like symptoms over six months and diurnal variability in peak expiratory flow rate was 56.7%. In case 2, his FEV1 after treatment (93%) increased by 25% compared to initial FEV1 (68%). Both cases were diagnosed as chlorine-induced reactive airways dysfunction syndrome (RADS) on the basis of these clinical features. The most frequent chief complaints of the 209 non-hospitalized patients were headache (22.7%), followed by eye irritation (18.2%), nausea (11.2%), and sore throat (10.8%), with asymptomatic patients accounting for 36.5%. The multiple-response analysis of individual symptom revealed headache (42.4%) to be the most frequent symptom, followed by eye irritation (30.5%), sore throat (30.0%), cough (29.6%), nausea (27.6%), and dizziness (27.3%).

Conclusions

The 2 patients hospitalized after exposure to chlorine gas at the leakage site showed a clinical course corresponding to RADS. All of the 209 non-hospitalized patients only complained of symptoms of the upper airways and mucous membrane irritation.

Citations

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Chlorine gas exposure and evolutive patterns of reactive airways dysfunction syndrome: a systematic review
Angelica dos Santos Vianna, Ana Clara Poyares de Mello Bhering, Fernanda Cavalcante Antunes da Silva, Rosa Cristina dos Santos Vianna, Aline de Souza Espindola Santos
Revista Brasileira de Saúde Ocupacional.2023;[Epub] CrossRef
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Dose and gender dependence of chlorine inhalation in a conscious ovine model
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Scientific Reports.2023;[Epub] CrossRef
Ophthalmic Manifestations of Chlorine Gas Exposure: What Do We Know So Far?
Khayry Al-Shami, Salman Almurabi , Jafar Shatnawi, Khaled Qasagsah, Ghayda' Shatnawi, Abdulqadir J Nashwan
Cureus.2023;[Epub] CrossRef
Comparative Analysis of Hydrogen Fluoride-Exposed Patients Based on Major Burn Criteria After the 2012 Gumi City Chemical Leak Disaster
Heejun Shin, Se Kwang Oh, Han You Lee, Heajin Chung, Seong Yong Yoon, Sung Yong Choi
Journal of Burn Care & Research.2022; 43(4): 834. CrossRef
Human chlorine gas exposition and its management – an umbrella review on human data
Aboubakari Nambiema, Gabrielle Coyo, Jean-Baptiste Barbe-Richaud, Jeremy Blottiaux, Nicolas Retière-Doré, Grace Sembajwe, Alexis Descatha
Critical Reviews in Toxicology.2022; 52(1): 32. CrossRef
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Chang Won Park, Seong Hun Kim, Soo Hyung Lee, Shinwoo Kim, Woo Young Nho
Clinical and Experimental Emergency Medicine.2022; 9(3): 262. CrossRef
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Lessons learned from reviewing a hospital’s disaster response to the hydrofluoric acid leak in Gumi city in 2012
Heejun Shin, Se Kwang Oh, Han You Lee, Heajin Chung, Seong Yong Yoon, Sung Yong Choi, Jae Hyuk Kim
BMC Emergency Medicine.2021;[Epub] CrossRef
Forensic issues arising in the assessment of chlorine-related deaths in a domestic setting
Judith Fronczek, John D Gilbert, Roger W Byard
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Acute accidental inhalation of Chlorine gas: A mini review
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Choking agents and chlorine gas – History, pathophysiology, clinical effects and treatment
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Updated review of reported cases of reactive airways dysfunction syndrome
G I Walters, C C Huntley
Occupational Medicine.2020; 70(7): 490. CrossRef
Aggravation of asthmatic inflammation by chlorine exposure via innate lymphoid cells and CD11cintermediate macrophages
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Chemical pneumonitis in a 9-year-old following chlorine gas exposure
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Chlorine exposure during a biological decontamination study in a mock subway tunnel
John D. Archer, Rebecca DeVries, Andrew J. Imler
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Civilian exposure to chlorine gas: A systematic review
P. Govier, J.M. Coulson
Toxicology Letters.2018; 293: 249. CrossRef
Acute respiratory symptoms and evacuation-related behavior after exposure to chlorine gas leakage
Sung-Woo Han, Won-Jun Choi, Min-Kee Yi, Seng-Ho Song, Dong-Hoon Lee, Sang-Hwan Han
Annals of Occupational and Environmental Medicine.2016;[Epub] CrossRef
Deliberate exposure of humans to chlorine-the aftermath of Ebola in West Africa
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Factors Associating Major Burn in Chemical Injury Patients due to Industrial Place Incident : A Retrospective study
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Journal of the Korea Academia-Industrial cooperation Society.2016; 17(4): 332. CrossRef

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Acute Symptoms in Firefighters who Participated in Collection Work after the Community Hydrogen Fluoride Spill Accident: Seong-Yong Cho, Kuck-Hyun Woo, Jin-Seok Kim, Seong-Yong Yoon, Joo-Yong Na, Jin-Hyun Yu, Yong-Bae Kim; Ann Occup Environ Med 2013;25:36-36. Published online November 28, 2013; DOI: https://doi.org/10.1186/2052-4374-25-36

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Objectives

This study aimed to analyze the relationship between clinical status and work characteristics of firefighters and other public officers who engaged on collection duties in the site of the hydrogen fluoride spill that occurred on September 27, 2012, in Gumi City, South Korea.

Methods

We investigated the clinical status, personal history, and work characteristics of the study subjects and performed physical examination and several clinical examinations, including chest radiography, echocardiography, pulmonary function test, and blood testing in 348 firefighters, police officers, volunteer firefighters, and special warfare reserved force who worked at the hydrogen fluoride spill area.

Results

The subjects who worked near the accident site more frequently experienced eye symptoms (p = 0.026), cough (p = 0.017), and headache (p = 0.003) than the subjects who worked farther from the accident site. The longer the working hours at the accident area, the more frequently the subjects experienced pulmonary (p = 0.027), sputum (p = 0.043), and vomiting symptoms (p = 0.003). The subjects who did not wear respiratory protective devices more frequently experienced dyspnea than those who wore respiratory protective devices (p = 0.013). In the pulmonary function test, the subjects who worked near the accident site had a higher decease in forced vital capacity than the subjects who worked farther from the site (p = 0.019); however, no statistical association was found between serum calcium/phosphate level, echocardiography result, chest radiographic result, and probation work characteristics.

Conclusions

The subjects who worked near the site of the hydrogen fluoride spill, worked for an extended period, or worked without wearing respiratory protective devices more frequently experienced upper/lower respiratory, gastrointestinal, and neurological symptoms. Further follow-up examination is needed for the workers who were exposed to hydrogen fluoride during their collection duties in the chemical plant in Gumi City.

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Occupational Factors Associated with Changes in the Body Mass Index of Korean Male Manual Workers: In-Woong Song, Kuck-Hyun Woo, Jin-Seok Kim, Seong-Yong Yoon, Joo-Yong Na, Jin-Hyun Yu, Seong-Yong Cho; Ann Occup Environ Med 2013;25:40-40. Published online December 27, 2013; DOI: https://doi.org/10.1186/2052-4374-25-40

Abstract PDF PubReader ePub

Objectives

This study was carried out to analyze and compare the occupational factors that could influence changes in body mass index (BMI) in male manual workers stratified into short-term and long-term work experience groups.

Methods

The subjects were 299 male manual workers (sampled systematically) from 27 workplaces, who had undergone travelling medical examinations at a university hospital between March 28 and May 10, 2013, and had also undergone medical examinations at the same hospital in 2012. Their general and occupational characteristics were investigated through a structured, self-administered questionnaire. The BMI at each point in time was calculated based on the anthropometric results of the medical examinations. Multiple regression analyses were conducted on outcomes of the BMI change and predictors composed of the general and occupational characteristics, with the subjects stratified into groups with 5 years or less (short-term) versus more than 5 years (long-term) of work experience at the present post.

Results

In the short-term work experience group, the BMI increases of 3-shift workers and groups reporting disagreement with feeling “insufficient job control” and “lack of reward” at work, two of the subscales of job stress, were significantly higher than those of daytime workers and high-stress groups, respectively. In the long-term work experience group, However, although the BMI increase for 3-shift workers was also significantly higher than that of daytime workers, none of the job stress factors were significantly associated with a BMI increase, whereas the social factors of education and marital status were significant, and some lifestyle factors (such as smoking and regular exercise) were also significant.

Conclusion

This study showed that, except for 3-shift work, the factors associated with BMI increase could differ depending on the length of job experience. Consequently, different strategies may be needed for workers with short-term versus long-term job experience when designing interventions for preventing their obesity.

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