Annals of Occupational and Environmental Medicine

Jin Ho Chun

10 Articles

Monitoring of Polycyclic Aromatic Hydrocarbons and the metabolites in Workers using Coal tar Paints: Eun A Kim, Jong Tae Lee, Eun Hye Kwon, Jong Seong Lee, Yong Hack Lee, Hyun Seok Kwag, Seong Bong Choi, Iu Jin Lee, Jae Hoon Shin, Kwang Jin Shim, Sang Hwa Urm, Sung Jun Kim, Hae Sook Shon, Jin Ho Chun; Korean Journal of Occupational and Environmental Medicine 2005;17(3):161-172. Published online September 30, 2005; DOI: https://doi.org/10.35371/kjoem.2005.17.3.161

OBJECTIVE: In this study, the exposure levels of polycyclic aromatic hydrocarbons (PAHs) and urinary 1-hydroxypyrene(1-OHP) were surveyed among the workers using coal tar paint.
METHOD
The study subjects for the exposed group were 107 male coal tar workers in 10 factories, and for the comparison group were 201 male clerk workers who had never been exposed to coal tar paint. Ambient PAHs, and pre-shift and end-shift urinary 1-OHP were sample and 16 PAHs were analysed. Smoking history was recorded during the survey day.
RESULTS
The geometric mean of ambient concentration of total PAHs was 120.17 microgram/m3. Naphthalene had the highest level among the 16 PAHs. The pre-shift 1-OHP in the exposed group (8.89 micro mol/mol creatinine) was significantly higher than that in the control group (0.29 micro mol/mol creatinine). The end-shift 1-OHP in the exposed group (19.02 micro mol/mol creatinine) was significantly higher than that in the pre-shift (8.89 micro mol/mol creatinine) (Ed- confirm). 1-OHP of smokers was significantly higher than that of non-smokers in both groups. The difference between pre-shift and end-shift 1-OHP in smokers (12.40 micro mol/mol creatinine) was twice as high as that in non-smokers (6.06 micro mol/mol creatinine). The difference of 1-OHP between smokers and nonsmokers was 7.59 micro mol/mol creatinine in pre-shift and 13.96 micro mol/mol creatinine in end-shift. Thus, the effect of smoking and exposure to PAHs on 1-OHP may not be additive. In regression analysis for 1-OHP, the significant independent variables were pre-shift 1-OHP and PAHs. The direction of these variables was positive. When the analysis was performed in workers exposed to higher PAHs, smoking was significant independent variable.
CONCLUSION
The above results suggest that not only ambient PAHs but also smoking, one of the most important non-occupational PAHs source, influenced the level of 1-OHP. Moreover, the effect of smoking to 1-OHP changed according to the exposure level of PAHs.

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Overview of occupational cancer in painters in Korea
Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef
A study of the status of exposure to polycyclic aromatic hydrocarbons (PAHs) in relation to its metabolites among workers in a Korean chemical factory
Kwan Lee, Hyun-Sul Lim, Heon Kim
Ciência & Saúde Coletiva.2014; 19(12): 4809. CrossRef

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Effects of Cadmium on Placental Function and Reproduction in Rats: Jin Hong Ahn, Kwang Soo Ko, Chae Kwan Lee, Deog Hwan Moon, Byung Chul Son, Dae Hwan Kim, Chang Hee Lee, Hwi Dong Kim, Jung Won Kim, Jong Eun Kim, Jin Ho Chun, Chae Un Lee; Korean Journal of Occupational and Environmental Medicine 2004;16(3):236-249. Published online September 30, 2004; DOI: https://doi.org/10.35371/kjoem.2004.16.3.236

Abstract PDF: OBJECTIVES
This study investigated the toxic effects of cadmium on placental function and reproduction in rats. For this study, the mRNA levels of the placental prolactin-growth hormone (PRL-GH) gene family, placental trophoblast cell frequemcy and reproductive data were analyzed.
METHODS
Pregnant F344 Fisher rats (200 g+/-23 g) were intraperitoneally injected with 0, 0.5, and 5.0 mg/kg B.W/day of cadmium (CdCl2) dissolved in saline from days 7-11 or 16-20 of pregnancy, and were sacrificed at days 11 or 20, respectively. The mRNA levels were analyzed by Northern blot hybridization and reverse transcription-polymerase chain reaction. The hormone concentration was analyzed by radioimmunoassay and the frequemcy of the placental trophoblast cells was observed by histochemical study. Reproductive data were surveyed at day 20 of the pregnancy and after the births. Statistical analysis was carried out using the SAS program (version 8.1).
RESULTS
The mRNA levels of the PRL-GH gene family were reduced dose dependently by cadmium. The mRNA levels of Pit-1a and -b isotype genes were also reduced by cadmium. The hormone concentration of PL-Iv and -II was decreased by cadmium. During the second half of pregnancy (days 11-21), a high dose of cadmium exposure significantly reduced the frequency of spongiotrophoblast and trophoblast giant cells that secrete the PRL-GH hormones. In the last stage of pregnancy (day 20), a high dose of cadmium exposure induced the apoptosis of spon-giotrophoblast cells in the junctional zone of the placenta. Reproductive data such as placental and infant weight, number of live fetuses were decreased, and number of resorptions and dead fetuses, post-implantation loss were increased significantly in the cadmium exposed group compared with the control.
CONCLUSIONS
Cadmium disrupts the functions of the placenta and these effects leads to reproductive disorders in rats.

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Effects of Chromium Exposure on the Level of Urinary 8-Hydroxydeoxyguanosine: Seong Joon Kim, Byung Chul Yu, Sang Hwa Ohm, Ki Won Jeong, Luck Hee Sung, Won Chang Shin, Jong Rae Cho, Jin Ho Chun; Korean Journal of Occupational and Environmental Medicine 2001;13(3):253-261. Published online September 30, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.3.253

Abstract PDF

OBJECTIVES
To investigate the possibility of utilizing DNA adduct as a carcinogenic biological marker for workers exposed to chromium, and the effect of chromium exposure on the formation of urinary 8-hydroxydeoxyguanosine(8-OH-dG) was also evaluated.
METHODS
The chromium concentrations of venous blood and urine were measured in 20 chromium exposed workers(exposure group) and in 11 chromium workers(control group) who were not exposed. The concentration of 8-OH-dG in their urine was determined using high performance liquid chromatography with electrochemical detection.
RESULTS
The blood chromium concentration was significantly higher in the exposure group ( 0.46+/-0.18 microgram/100 ml) than in control group(0.27+/-0.15 microgram/100 ml), but the urinary chromium concentration was not significantly higher in the exposure group. The urinary 8-OH-dG was higher in the exposure group(1.71+/-1.82 micromol/mol creatinine) than that in the control group(0.45+/-0.46 micromol/mol creatinine) and was significantly correlated with the blood chromium concentration(r=0.49). Results of multiple regression analysis revealed that the level of urinary 8-OH-dG depended upon the level of the blood chromium conc entration ( r2= 0.21).
CONCLUSIONS
Urinary 8-OH-dG was significantly related to chromium exposure and this finding suggests the possibility that urinary 8-OH-dG could be used as a biological index of chromium induced DNA damage.

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Association of serum and hair antioxidant minerals with an oxidative stress marker in relation with characteristics of healthy adults: a cross-sectional study
Yoo-Ree Kang, Mi-Kyung Sung, Hyun-Wook Baik, Mi-Kyeong Choi
Scientific Reports.2024;[Epub] CrossRef

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Work Related Musculoskeletal Disorders of Hairdresser: Soo Kyung Park, Young Jin Choi, Doeg Hwan Moon, Jin Ho Chun, Jong Tae Lee, Hae Sook Sohn; Korean Journal of Occupational and Environmental Medicine 2000;12(3):395-404. Published online September 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.3.395

Abstract PDF

OBJECTIVES
To determine the prevalence and related factors of work related musculoskeletal symptoms in hairdressers.
METHODS
Informations on general characteristics, job strain, and musculoskeletal symptoms were obtained by a self-administered questionnaire, through adopting NIOSH instrument and JCQ(Job content questionnaire), from 267 hairdressers, between March and May, 2000.
RESULTS
The symptom prevalence by NIOSH surveillance criteria in total was high as 94.4%; shoulder (61.0%), neck (59.9%), low back (53.2%), hand and wrist (41.6%), etc. In multiple logistic regression, significant factors affecting the symptoms by body region; job insecurity on neck' gender, alcohol, decision latitude on low back; alcohol on hand and wrist; smoking on thigh and knee,' smoking, decision latitude on ankle and foot; job insecurity on upper back.
CONCLUSIONS
Musculoskeletal symptoms of hairdresser were highly prevalent, and associated with job strain and their health habits. This is a basic data of work related musculoskeletal disorders among hairdressers who are not the subjects of occupational health service at the present time in Korea.

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Relationship between simultaneous exposure to ergonomic risk factors and work-related lower back pain: a cross-sectional study based on the fourth Korean working conditions survey
Jae-Yeop Kim, Ji-Su Shin, Myeong-Seob Lim, Hyeon-Gyeong Choi, Sung-Kyeong Kim, Hee-Tae Kang, Sang-Baek Koh, Sung-Soo Oh
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef
Risk Factors for Musculoskeletal Symptoms Among Korean Broadcast Actors
Moon-Hee Park, Ham-Gyum Kim, Jae-Hwan Cho
Annals of Global Health.2015; 81(4): 475. CrossRef
Musculoskeletal Disorder Symptoms and Its Related Factors among Male Workers in Manufacturing Industries
Seung-Hyun Lee, Young-Chae Cho
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(10): 6627. CrossRef
Risk Factors for Musculoskeletal Symptoms Among Korean Radiation Workers
Jae-Hwan Cho, Moo-Seong Cho, Jae-Ouk Ahn
Archives of Environmental & Occupational Health.2015; 70(3): 160. CrossRef
Prevalence of Musculoskeletal Disorders Among Korean Police Personnel
Hak Young Rhee, Jae Hwan Cho, Jong Min Seok, Taek Sang Cho, Woo Jin Jeon, Jin Gu Lee, Sung Kyu Kim
Archives of Environmental & Occupational Health.2015; 70(4): 177. CrossRef
Relationship between occupational stress and musculoskeletal symptoms of upper extremities among dental hygienists
So-Young Lee, Hyo-Jin Ko, Byeng-Chul Yu
Journal of Korean society of Dental Hygiene.2012; 12(5): 897. CrossRef
Leg Length Inequality, Habitual Posture, and Pain in Women's College Students
Sung-Bok Kwon, Yeo-Jin Yi, Hye-Ja Han, Kyung-Sook Cho, Nan-Young Lim, Eun-Hee Lee, Haeng-Mi Son, Young-Sook Park, Joo-Hyun Kim, Hyun-Sook Kang
Journal of muscle and joint health.2012; 19(1): 27. CrossRef
Musculoskeletal Disorder Symptoms and Related Factors among Male Workers in Small-scale Manufacturing Industries
Seung-Hyun Lee, Ju-Yeon Lee, Young-Chae Cho
Journal of the Korea Academia-Industrial cooperation Society.2012; 13(9): 4025. CrossRef
Musculoskeletal Symptoms and Its Related Factors among Male Workers in a Nonferrous Manufacturing Industry
Yeon-Ok Jeong, Young-Chae Cho
Journal of the Korea Academia-Industrial cooperation Society.2012; 13(8): 3552. CrossRef
Risk Factors of Work-related Upper Extremity Musculoskeletal Disorders in Male Shipyard Workers: Structural Equation Model Analysis
Byung-Chan Park, Hae-Kwan Cheong, Eun-A Kim, Soo Geun Kim
Safety and Health at Work.2010; 1(2): 124. CrossRef
Work-related Musculoskeletal Disorders in Firefighters
Seong-Kyu Kang, Wook Kim
Journal of the Korean Medical Association.2008; 51(12): 1111. CrossRef
Musculoskeletal disorders among staff in South Korea’s largest nursing home
Derek Richard Smith, Jae-wook Choi, Myung Ki, Jae-young Kim, Zentaro Yamagata
Environmental Health and Preventive Medicine.2003; 8(1): 23. CrossRef

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CYP2E1 Genetic Polymorphism relating to Styrene Metabolism of Korean Workers: Chang Hee Lee, Jin Ho Chun, Jun Han Park, Dong Mug Kang, Dae Hwan Kim, Deog Hwan Moon, Chae Un Lee; Korean Journal of Occupational and Environmental Medicine 1999;11(2):161-173. Published online June 30, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.2.161

Abstract PDF: The goal of this study is to observe the associations between the metabolic phenotype by personal exposure and urinary metabolites and genetic polymorphism of CYP2E1 which is known to be related with styrene metabolism. To complete this study, the author executed a battery of tests on 46 workers who were working at laminating department of fiberglass- reinforced plastics (FRP) industry located in Pusan and Kyungnam area during April to June 1998. Those were - (1) personal exposure assessment with organic vapour monitor and gas chromatography. (2) measurement of urinary metabolites - mandelic acid (MA) and phenylglyoxylic acid (PGA) - with high performance liquid chromatography (HIPLC), (3) CYP2E1 genotying with PCR and restriction fragment length polymorphism (RFLP) using Dra I and Rsa I, and (4) questionnaire survey for some individual characteristics. Study subjects were composed of 32 men and 14 women, and whose average age was 39.4 years, average tenure was 7.7 years. Each concentration expressed by geometric mean(range) was as follows; air styrene 15.6(3.1-81.0) ppm, urinary MA 187.8(36.8-1007.2) mg/g creatinine, PGA 232.8(46.8-1075.7) mg/g creatinine. Correlation coefficients between air styrene were MA 0.54, PGA 0.37, MA+PGA 0.54 (p < 0.05). The relative frequency of CYP2E1 mutant allele was 45.7%(Dra I 43.5%, lIsa 1 37.0%), and homozygous mutant type (M/M) was not observed. The value of (geometric mean of (air styrene/urinary metabolites)) x 1000 according to genotype was significantly higher in mutant type than wild type (p<0.05), as in case of MA, mutant type 106.4 and wild type 84.4, and in case of MA+PGA, mutant type 84.4 and wild type 55.6. The value of air styeneTLV-TWA/urinary metabolitesBEI was used as a cut-off value of classifying phenotype. That is, the value of air styeneTLV-TWA/urinary MABEI >or= 0.063 and air styreneTLV-TWA/urinary MA+PGABEI >or= 0.048 was classified as poor metabolizer, and, the value of air styreneTLV-TWA/urinary MABEI~ < 0.063 and air styreneThV~A/urinary MA+PGABEI < 0.048 was classified as extensive metabolizer. As the result, the frequency of poor metabolizer was higher in mutant type than wild type with no statistical significance (p > 0.05), as in case of MA, mutant type 66.7% and wild type 48.0%, and in case of MA+PGA, mutant type 81.0% and wild type 56.0%. These results suggests that CYP2E1 mutant allele has a tendency toward the poor metabolizer. This study has several limitations as small sample size, and no considerations on work intensity, alcohol habit, obesity, etc which can affect styrene metabolism. However, this study is of value because this is first study to propose the fundamental data about associations between exposure level, biological monitoring, and CYP2E1 genetic polymorphism in Korean workers dealing with pure styrene. To improve accuracy of the study, that means, to applicate the result of this study on the personal risk assessment of styrene workers, larger sample size and consideration for confounders are needed.

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Effects of Toluene, Xylene and Trichloroethylene on the Regulation of GnRH, GnRH Receptor and Pit-1 Gene Expression in Male Rat Hypothalamus and Pituitary: Dae Hwan Kim, Hun Lee, Chae Kwan Lee, Dae Sung Kang, Jung Ho Kim, Jong Tae Lee, Jin Ho Chun, Chae Un Lee, No Suk Ki; Korean Journal of Occupational and Environmental Medicine 1998;10(2):267-281. Published online May 31, 1998; DOI: https://doi.org/10.35371/kjoem.1998.10.2.267

Abstract PDF: The workplace exposure of chemicals has steadily increased, therefore the concern for subsequent effect on reproductive outcome has been an important issue in occupational medicine. In previous studies, higher rates of spontaneous abortion, reduced fertility and menstrual disorder among women, and an impairment of sperm quantity and quality among men have been associated with a wide variety of chemical agents. This study was conducted to evaluate the effects of toluene, xylene and trichloroethylene (TCE) injection on the mRNA levels of GnRH, GnRH receptor and Pit-1 genes in male rats hypothalamus and pituitary and the effects on the plasma levels of FSH, LH, prolactin and testosterone. Sprague-Dawley male rats were divided into five groups of five each according to concentration of toluene, xylene and TCE. The rats were injected subcutaneously to 0, 50, 100, 200, 400 mg/kg body weight/day of toluene, xylene and TCE, respectively for 6 days. Rat brains were excised and hypothalamus and pituitary were separated. Reverse transcription-polymerase chain reaction (RT-PCR) and RNase protection assay (RPA) were used to evaluate the GnRH, GnRH receptor and Pit-1 mRNA levels. Plasma concentrations of FSH, LH, prolactin and testosterone were assayed by radioimulunoassay (RIA). The results were as follows; 1. GnRH, GnRH receptor and Pit-1 mRNA levels in toluene and xylene injected groups, and GnRH receptor mRNA levels in TCE injected group were lowered dose-dependently. Especially, GnRH receptor and Pit-1 mRNA levels in 200 mg/kg of toluene injected group, and GnRH, GnRH receptor and Pit-1 mRNA levels in 400 mg/kg of toluene injected group were significantly lowed than control group (p<0.05). GnRH receptor and Pit-1 mRNA levels in 400 mg/kg of xylene injected group, and GnRH receptor mRNA levels in 400 mg/kg of TCE injected group were significantly lower than control group (p<0.05). 2. The plasma levels of prolactin and testosterone in 400 mg/kg of toluene injected group, and LH in 100, 200 and 400 mg/kg of xylene injected group, and testosterone in 400 mg/kg of TCE injected group were significantly lower than control group (p<0.05). In conclusion, we speculated that toluene and xylene affected reproductive system secondarily through hypothalamus-pituitary axis, and TCE affected directly through steroidogenesis. And we recomended that further study for assessment of the reproductive toxiclty of mixed organic solvent exposures should be conducted.

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Relating Factors of Industrial Accident: Dae Suk Ko, Soon Suk Choi, Soo Jin Jung, Jun Han Park, Hun Lee, Byung Chul Son, Sang Hwa Urm, Chae Un Lee, Ki Taek Bae, Jin Ho Chun; Korean Journal of Occupational and Environmental Medicine 1997;9(1):99-108. Published online February 28, 1997; DOI: https://doi.org/10.35371/kjoem.1997.9.1.99

Abstract PDF

This study was conducted to estimate the causing factors of industrial accident, and to prepare the fittable control program for accident through the evaluation of views of the patients who suffered from accidents. From January 5 to February 6 1993, questionnaire survey was executed on 166 persons who were injured and covered by the insurance under industrial accident compensation law at four university hospitals in Pusan. The results were as follows : 1. Most of subjects worked in the manufacturing (56.6%) and construction(29.5%), and in the small factory less than 49 workers(56.0%). They were thirties and forties(63.8%), less than 3 years tenure(53.6%), habitual drinker(69.2%). And, 72.3% worked for above 9 hours per day, 53.6% worked as near clerks, 89.2% thought that work is rather suitable to his own personality. 2. Self-recognition for the causing factor of industrial accident was the other's malfunction(19.3%), carelessness(15.1%), lack of education for safety(15.1%), and they thought the accident occurred by mainly some defect of establishment and working environment(34.9%), unskillfulness(22.9%), self-carelessness(22.3%). 3. The interests and recognition on safety was insufficient, 88.6% require job education, but 53% pointed out the necessity for strengthening of present status-rather incomplete with relying on self-education (40.9%), no previous participation in safety education (29.5%), etc. 4. For the kind of accident, fall-down(16.3%), crash(13.3%), falling(12.7%) was frequent, head(24.7%) and fracture(41.0%) was frequent for the part and type of injury, respectively. And, they had more injured by cooperative work (82.5%) than single work. As results, improvement of working environment and strengthening education program would be emphasized for the effective control of industrial accident. And, there should be prepared the specific prevention program for the small scale industries.

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3D motion analysis of the wrist splint effect to wrist joint movement
Joong-il Shin, Soo-hee Park
Journal of Physical Therapy Science.2017; 29(6): 1089. CrossRef
A basic research on risk control measure for reducing the fishermen's occupational accident in offshore and coastal fishing vessel
Wook-Sung Kim, Young-Bok Cho, Seok-Jae Kim, Kyong-Jin Ryu, Yoo-Won Lee
Journal of the Korean society of Fisheries Technology.2014; 50(4): 614. CrossRef

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Neuroendocrine Effects in Occupational Solvents Exposure: Chae Un Lee, Jong Tae Lee, Ui Wha Chung, Hae Suk Sohn, Deog Hwan Moon, Jin Ho Chun, Jung Hak Kang, Chang Hee Lee, Hwi Dong Kim, Jong Ham Kim, Kui Oak Jung; Korean Journal of Occupational and Environmental Medicine 1995;7(2):362-374. Published online October 31, 1995; DOI: https://doi.org/10.35371/kjoem.1995.7.2.362

Abstract PDF

Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic solvents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls (33men, 85women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone (FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone (GH), and thyroid-stimulating hormone (TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones (FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.

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Risk Assessment for Non-Cancer Effects of Volatile Organic Compounds in Children's Products
Jungkon Kim, Jung-Kwan Seo, Taksoo Kim, Gun-Ho Park
Korean Journal of Environmental Health Sciences.2014; 40(3): 178. CrossRef

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Atmospheric toluene concentration and urinary hippuric acid concentration according to the time of shift: Tae Young Han, Jin Ho Chun, Sung Joon Kim, Sang Hwa Ohm, Dae Hwan Kim, Byung Chul Yoo, Chai Eon Lee; Korean Journal of Occupational and Environmental Medicine 1993;5(2):205-214. Published online September 30, 1993; DOI: https://doi.org/10.35371/kjoem.1993.5.2.205

Abstract PDF: No abstract available.

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Comparison of environmental and personal exposure concentration of dust: Chan Ho Kim, Jin Ho Chun, Hae Sook Shon, Byung Chul Yoo, Seong Yong Choi, Sung Chun Kim, Chae Un Lee; Korean Journal of Occupational and Environmental Medicine 1993;5(2):171-186. Published online September 30, 1993; DOI: https://doi.org/10.35371/kjoem.1993.5.2.171

Abstract PDF: No abstract available.

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