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A case of chronic myeloid leukemia in a diagnostic radiographer
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Chulyong Park, Sungyeul Choi, Dohyung Kim, Jaechan Park, Saerom Lee
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Ann Occup Environ Med 2014;26:54. Published online November 28, 2014
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DOI: https://doi.org/10.1186/s40557-014-0054-8
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Abstract
PDFPubReaderePub
- Background
Occupational radiation exposure causes certain types of cancer, specifically hematopoietic diseases like leukemia. In Korea, radiation exposure is monitored and recorded by law, and guidelines for compensation of radiation-related diseases were implemented in 2001. However, thus far, no occupation-related disease was approved for compensation under these guidelines. Here, we report the first case of radiation-related disease approved by the compensation committee of the Korea Workers’ Compensation and Welfare Service, based on the probability of causation. Case presentationA 45-year-old man complained of chronic fatigue and myalgia for several days. He was diagnosed with chronic myeloid leukemia. The patient was a diagnostic radiographer at a diagnostic radiation department and was exposed to ionizing radiation for 21 years before chronic myeloid leukemia was diagnosed. His job involved taking simple radiographs, computed tomography scans, and measuring bone marrow density. ConclusionTo our knowledge, this is the first approved case report using quantitative assessment of radiation. More approved cases are expected based on objective radiation exposure data and the probability of causation. We need to find a resolution to the ongoing demands for appropriate compensation and improvements to the environment at radiation workplaces.
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Citations
Citations to this article as recorded by
- Does occupational ionizing radiation exposure in healthcare workers affect their hematological parameters?
Nejdiye Güngördü, Seher Kurtul, Ayşenur Özdil, Mehmet Sarper Erdoğan Archives of Environmental & Occupational Health.2023; 78(2): 80. CrossRef - Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
Ning Liu, Yang Peng, Xinguang Zhong, Zheng Ma, Suiping He, Ying Li, Wencui Zhang, Zijun Gong, Zhenjiang Yao Environmental Health and Preventive Medicine.2021;[Epub] CrossRef
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A Case of Tracheal Adenoid Cystic Carcinoma in a Worker Exposed to Rubber Fumes
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Dohyung Kim, Yang-In Hwang, Sungyeul Choi, Chulyong Park, Naroo Lee, Eun-A Kim
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Ann Occup Environ Med 2013;25:22-22. Published online October 17, 2013
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DOI: https://doi.org/10.1186/2052-4374-25-22
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Abstract
PDFPubReaderePub
- Background
Primary tracheal tumors occur infrequently, accounting for less than 0.1% of all tumors. Adenoid cystic carcinoma (ACC) is the second most common type of malignancy of the trachea after squamous cell carcinoma (SCC). Little has been reported on the risk factors for tracheal ACC. The purpose of this study is to describe a case of tracheal ACC in a patient who had been exposed to rubber fumes, and to review the relationship between tracheal ACC and rubber fumes. Case reportA 48-year-old man who had been experiencing aggravation of dyspnea for several months was diagnosed as having ACC of the trachea on the basis of a pathologic examination of a biopsy specimen obtained via laser microscopy-guided resection. The patient had been exposed to rubber fumes for 10 years at a tire manufacturing factory where he worked until ACC was diagnosed. His job involved preheating and changing rubber molds during the curing process. ConclusionACC of both the trachea and the salivary glands show very similar patterns with regard to histopathology and epidemiology and are therefore assumed to have a common etiology. Rubber manufacturing is an occupational risk factor for the development of salivary gland tumors. Further, rubber fumes have been reported to be mutagenic. The exposure level to rubber fumes during the curing process at the patient’s workplace was estimated to be close to or higher than British Occupational Exposure Limits. Therefore, tracheal ACC in this case might have been influenced by occupational exposure to rubber fumes.
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Citations
Citations to this article as recorded by
- Tracheal adenoid cystic carcinoma with microscopic positive margin—how we approached with a systematic analysis review of its management
Sivakumar Krishnasamy, Chu-Yik Tang, Pheng Hian Tan Indian Journal of Thoracic and Cardiovascular Surgery.2024; 40(3): 332. CrossRef - Trakea Yerleşimli Adenoid Kistik Karsinom: Olgu Sunumu
Deniz KÜTRİ, Alaattin ÖZEN, Suzan ŞAYLISOY Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi.2021; 8(3): 227. CrossRef - Candida Infection Associated with Salivary Gland—A Narrative Review
Soo-Min Ok, Donald Ho, Tyler Lynd, Yong-Woo Ahn, Hye-Min Ju, Sung-Hee Jeong, Kyounga Cheon Journal of Clinical Medicine.2020; 10(1): 97. CrossRef - Polyomavirus JCPyV infrequently detectable in adenoid cystic carcinoma of the oral cavity and the airways
Hanna Hämetoja, Jaana Hagström, Caj Haglund, Leif Bäck, Antti Mäkitie, Stina Syrjänen Virchows Archiv.2019; 475(5): 609. CrossRef - Adenoid Cystic Carcinoma of the Trachea
Santhosh Kumar N, Elizabeth Mathew Iype, Shaji Thomas, Uma V. Sankar Indian Journal of Surgical Oncology.2016; 7(1): 62. CrossRef
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Subclinical interstitial lung damage in workers exposed to indium compounds
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Sungyeul Choi, Yong-Lim Won, Dohyung Kim, Gwang-Yong Yi, Jai-Soung Park, Eun-A Kim
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Ann Occup Environ Med 2013;25:24-24. Published online October 21, 2013
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DOI: https://doi.org/10.1186/2052-4374-25-24
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Abstract
PDFPubReaderePub
- Objectives
The present study was designed to determine whether there is a relationship between indium compound exposure and interstitial lung damage in workers employed at indium tin oxide manufacturing and reclaiming factories in Korea. MethodsIn 2012, we conducted a study for the prevention of indium induced lung damage in Korea and identified 78 workers who had serum indium or Krebs von den Lungen-6 (KL-6) levels that were higher than the reference values set in Japan (3 μg/L and 500 U/mL, respectively). Thirty-four of the 78 workers underwent chest high-resolution computed tomography (HRCT), and their data were used for statistical analysis. ResultsGeometric means (geometric standard deviations) for serum indium, KL-6, and surfactant protein D (SP-D) were 10.9 (6.65) μg/L, 859.0 (1.85) U/mL, and 179.27 (1.81) ng/mL, respectively. HRCT showed intralobular interstitial thickening in 9 workers. A dose–response trend was statistically significant for blood KL-6 levels. All workers who had indium levels ≥50 μg/L had KL-6 levels that exceeded the reference values. However, dose–response trends for blood SP-D levels, KL-6 levels, SP-D levels, and interstitial changes on the HRCT scans were not significantly different. ConclusionsOur findings suggest that interstitial lung changes could be present in workers with indium exposure. Further studies are required and health risk information regarding indium exposure should be communicated to workers and employers in industries where indium compounds are used to prevent indium induced lung damage in Korea.
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Citations
Citations to this article as recorded by
- Pulmonary effects of exposure to indium and its compounds: cross-sectional survey of exposed workers and experimental findings in rodents
Nan Liu, Yi Guan, Yan Yu, Gai Li, Ling Xue, Weikang Li, Xiaoyu Qu, Ning Li, Sanqiao Yao Particle and Fibre Toxicology.2022;[Epub] CrossRef - Toxicokinetics and systematic responses of differently sized indium tin oxide (ITO) particles in mice via oropharyngeal aspiration exposure
Jing Qu, Jianli Wang, Haopeng Zhang, Jingying Wu, Xinmo Ma, Shile Wang, Yiteng Zang, Yuhui Huang, Ying Ma, Yuna Cao, Daming Wu, Ting Zhang Environmental Pollution.2021; 290: 117993. CrossRef - Assessment of Occupational Exposure to Indium Dust for Indium-Tin-Oxide Manufacturing Workers
Boo Wook Kim, Wonseok Cha, Sungwon Choi, Jungah Shin, Byung-Soon Choi, Miyeon Kim Biomolecules.2021; 11(3): 419. CrossRef - Biomonitorization of concentrations of 28 elements in serum and urine among workers exposed to indium compounds
Nan Liu, Yi Guan, Bin Li, Sanqiao Yao, Yi Hu PLOS ONE.2021; 16(2): e0246943. CrossRef - The early onset and persistent worsening pulmonary alveolar proteinosis in rats by indium oxide nanoparticles
Sung-Hyun Kim, Soyeon Jeon, Dong-Keun Lee, Seonghan Lee, Jiyoung Jeong, Jong Sung Kim, Wan-Seob Cho Nanotoxicology.2020; 14(4): 468. CrossRef - Effects of indium exposure on respiratory symptoms: a retrospective cohort study in Japanese workers using health checkup data
Toshiharu Mitsuhashi PeerJ.2020; 8: e8413. CrossRef - Application of the ICRP respiratory tract model to estimate pulmonary retention of industrially sampled indium-containing dusts
Aleksandr B. Stefaniak, M. Abbas Virji, Melissa A. Badding, Kristin J. Cummings Inhalation Toxicology.2017; 29(4): 169. CrossRef - Respirable indium exposures, plasma indium, and respiratory health among indium‐tin oxide (ITO) workers
Kristin J. Cummings, M. Abbas Virji, Ji Young Park, Marcia L. Stanton, Nicole T. Edwards, Bruce C. Trapnell, Brenna Carey, Aleksandr B. Stefaniak, Kathleen Kreiss American Journal of Industrial Medicine.2016; 59(7): 522. CrossRef - Indium oxide (In2O3) nanoparticles induce progressive lung injury distinct from lung injuries by copper oxide (CuO) and nickel oxide (NiO) nanoparticles
Jiyoung Jeong, Jeongeun Kim, Seung Hyeok Seok, Wan-Seob Cho Archives of Toxicology.2016; 90(4): 817. CrossRef - Interstitial lung disorders in the indium workers of Korea: An update study for the relationship with biological exposure indices
Sungyeul Choi, Yong Lim Won, Dohyung Kim, Mi‐Young Lee, Yoon jung Choi, Jai‐Soung Park, Hyoung‐Ryoul Kim, Jung Im Jung, Sang‐Gil Lee, Eun‐A Kim American Journal of Industrial Medicine.2015; 58(1): 61. CrossRef - Tissue distribution of indium after repeated intratracheal instillations of indium‐tin oxide into the lungs of hamsters
Akiyo Tanaka, Miyuki Hirata, Nagisa Matsumura, Yutaka Kiyohara Journal of Occupational Health.2015; 57(2): 189. CrossRef - Beryllium and other metal-induced lung disease
Annyce Mayer, Nabeel Hamzeh Current Opinion in Pulmonary Medicine.2015; 21(2): 178. CrossRef - Investigating the potential exposure risk to indium compounds of target manufacturing workers through an analysis of biological specimens
Yong Lim Won, Yoon Jung Choi, Sungyeul Choi, Eun-A Kim Journal of Korean Society of Occupational and Environmental Hygiene.2014; 24(3): 263. CrossRef - Early Changes in Clinical, Functional, and Laboratory Biomarkers in Workers at Risk of Indium Lung Disease
Kristin J. Cummings, M. Abbas Virji, Bruce C. Trapnell, Brenna Carey, Terrance Healey, Kathleen Kreiss Annals of the American Thoracic Society.2014; 11(9): 1395. CrossRef
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