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Collective exposure to lead from an approved natural product-derived drug in Korea
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Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
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Ann Occup Environ Med 2019;31:e20. Published online August 26, 2019
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DOI: https://doi.org/10.35371/aoem.2019.31.e20
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Abstract
PDFPubReaderePub
- Background
In Asian countries, including Korea, lead poisoning caused by traditional herbal medicines is often observed in the clinic. However, there have been no reports thus far of lead poisoning caused by drugs that were approved by the Korea Food and Drug Administration (KFDA). Here, we describe seven patients who ingested a problematic natural product-derived drug (NPD). Case presentationIn July 2018, seven patients visited a university hospital after ingesting an NPD, S. capsules. These patients complained of various symptoms, and their blood lead levels (BLLs) were elevated relative to those of the general population (arithmetic mean: 19.5 ± 11.6 µg/dL, range: 6.28–35.25 µg/dL). The total doses and BLLs were directly proportional to each other among the patients (r = 0.943, p = 0.001). After the patients discontinued drug intake, their BLLs decreased gradually. The capsule was confirmed to contain lead above the standard value (arithmetic mean: 2,547 ± 1,821.9 ppm). ConclusionThis incident highlights the need to strengthen standards for the management of NPD ingredients in Korea. NPDs are more likely to be contaminated than other drugs. Thorough management by the KFDA is essential to prevent a recurrence. Moreover, systematic health care is needed for many patients who have taken problematic NPDs.
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Citations
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- Lead and arsenic intoxications by traditional and alternative medicine: men are more sensitive than women
Lucia Gerke, Roland Seifert Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub] CrossRef - A Case of Severe Lead Poisoning with Basophilic Stippling Teardrop Cell
Wonyang Kang, Seunghyeon Cho, Dae-Young Lim, Suwhan Kim, Won-Ju Park Journal of Korean Medical Science.2019;[Epub] CrossRef
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